Microneedle system for tissue engineering and regenerative medicine

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 21, 2023

Abstract Global increasing demand for high life quality and length facilitates the development of tissue engineering regenerative medicine, which apply multidisciplinary theories techniques to achieve structural reconstruction functional recovery disordered or damaged tissues organs. However, clinical performances adopted drugs, materials, powerful cells in laboratory are inescapably limited by currently available technologies. To tackle problems, versatile microneedles developed as new platform local delivery diverse cargos with minimal invasion. The efficient delivery, well painless convenient procedure endow good patient compliance clinic. In this review, we first categorize different microneedle systems models, then summarize their applications medicine mainly involving maintenance rehabilitation end, discuss advantages, challenges, prospects depth future translations.

Language: Английский

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Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 16, 2024

Abstract Diabetic wounds are difficult to heal, and the key wound healing is exudate management effective disinfection. Inspired by asymmetric wettability of Janus‐structured lotus leaves, herein study has presented design a biomimetic Janus membrane that integrates unidirectional biofluid drainage photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic healing. This prepared electrospinning polyacrylonitrile (PAN) nanofiber containing polydopamine (PDA) on surface polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA enables antigravity “pumping” water from hydrophobic PP layer hydrophilic PAN within 22 s through contact points interface. The incorporation 30 wt% PDA in imparts high photoabsorption photothermal responsiveness, facilitating continuous volatilization exudate, achieving twice displacement water, causing irreversible damage bacteria. As result, it effectively alleviates inflammation cellular fibrosis while promoting collagen deposition due its structure antibacterial properties. Impressively, such achieves an impressive closure rate 96.7% wounds, better than (59.8%) conventional bandages. Therefore, this offers promising alternative chronic wounds.

Language: Английский

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Rapidly degrading and mussel-inspired multifunctional carboxymethyl chitosan/montmorillonite hydrogel for wound hemostasis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124960 - 124960

Published: May 23, 2023

Language: Английский

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Designing biomimetic scaffolds for skin tissue engineering

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(9), P. 3051 - 3076

Published: Jan. 1, 2023

This review offers systematic considerations of material design principles and fabrication techniques for biomimetic skin tissue engineering scaffolds.

Language: Английский

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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects

Engineering, Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to site lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are different kinds (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) treating various disorders, including superficial tumors, wounds, infections, inflammatory diseases, abnormal appearance. The improved by integrating advantages multiple perform combination therapy. Through careful designing, further modified with biomimetic structures responsive drug release from internal external stimuli enhance transdermal delivery efficiency robust outcomes. Some studies have proposed use drug-free a promising mechanotherapeutic strategy promote wound healing, scar removal, hair regeneration via mechanical communication pathway. Although several advantages, practical application suffers problems related industrial manufacture clinical evaluation, making it difficult translation. In this study, we summarized applications, emerging challenges, developmental prospects provide information on ways advance

Language: Английский

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Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1643 - 1661

Published: Jan. 1, 2024

Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.

Language: Английский

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Advances of calcium phosphate nanoceramics for the osteoinductive potential and mechanistic pathways in maxillofacial bone defect repair

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100033 - 100033

Published: Feb. 4, 2024

Maxillofacial bone defects, arising from congenital malformations, tumors, infections, and traumas, represent a common clinical condition that impairs patients' appearance, speech, motor functions. Calcium phosphate nanoceramics, which bear chemical composition similar to autologous bone, demonstrate strong biocompatibility osteoconductivity, making them an extensively applied material in defect repairing. Notably, these nanoceramics exhibit inherent osteoinductive properties ,which can stimulate osteogenesis at non-osseous sites ,without the need for additional cells or growth factors, aspects further expand their application repair. Nevertheless, precise mechanism of calcium remains elusive, differences vivo individual persist, thereby academic communities resolve pressing issues restrict use. This paper reviews advancements research on factors affecting biological process formation, aiming provide new insights treatment maxillofacial defects.

Language: Английский

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Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

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Microneedle-Based Approaches for Skin Disease Treatment

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 6, 2025

Abstract The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints conventional methods by their superior safety and efficacy through precise targeting, while simultaneously enabling painless delivery. Currently, are increasingly used carriers delivery, with loading insoluble drugs to improve treatment efficiency or combining bioactive substances construction efficient system maximize effects substances. preparation diverse, them meet requirements most applications. emergence addressed shortcomings associated drugs, expanded applications substances, improved in clinical practice. This review summarizes current information on application a variety such psoriasis, vitiligo, alopecia, hypertrophic scarring, atopic dermatitis, melanoma, acne, infections. future opportunities diseases also discussed. Despite substantial progress vectors, issues low poor mechanical strength during remain main challenges. Therefore, implementation MNs-based therapies remains limited, highlighting key research.

Language: Английский

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Biomimetic Hydrogel Containing Copper Sulfide Nanoparticles and Deferoxamine for Photothermal Therapy of Infected Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(8)

Published: Dec. 8, 2023

Abstract Inducing cell migration from the edges to center of a wound, promoting angiogenesis, and controlling bacterial infection are very important for diabetic wound healing. Incorporating growth factors antibiotics into hydrogels dressing is considered potential strategy meet these requirements. However, some present drawbacks greatly slow down their development toward application, such as short half‐life high price factors, low antibiotic efficiency against drug‐resistant bacteria, insufficient ability promote migration, etc. Deferoxamine (DFO) can upregulate expression HIF‐1α, thus stimulating secretion angiogenesis‐related endogenous factors. Copper sulfide (CuS) nanoparticles possess excellent antibacterial performance combined with photothermal therapy (PTT). Herein, DFO CuS incorporated biomimetic hydrogel, which mimics structure function extracellular matrix (ECM), abbreviated DFO/CuS‐ECMgel. This hydrogel expected be able adhesion degraded by cell‐secreted metalloproteinases (MMPs), then release at site exert therapeutic effects. As result, three crucial requirements healing, “beneficial effectively killing bacteria,” achieved simultaneously.

Language: Английский

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