Gels,
Journal Year:
2023,
Volume and Issue:
9(10), P. 806 - 806
Published: Oct. 7, 2023
Polymeric
hydrogels
are
a
complex
class
of
materials
with
one
common
feature—the
ability
to
form
three-dimensional
networks
capable
imbibing
large
amounts
water
or
biological
fluids
without
being
dissolved,
acting
as
self-sustained
containers
for
various
purposes,
including
pharmaceutical
and
biomedical
applications.
Transdermal
microneedles
pain-free
drug
delivery
system
that
continues
on
the
path
widespread
adoption—regulatory
guidelines
horizon,
investments
in
field
continue
grow
annually.
Recently,
have
generated
interest
transdermal
due
their
tunable
properties,
allowing
them
be
exploited
systems
extraction
tools.
As
hydrogel
new
emerging
technology,
fabrication
faces
challenges
must
resolved
redeem
themselves
viable
option.
This
article
discusses
from
material
perspective,
regardless
mechanism
action.
It
cites
recent
advances
formulation,
presents
relevant
characterization
methods,
manufacturing
regulatory
facing
these
technologies
before
approval.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 303 - 326
Published: April 18, 2023
Microneedle,
as
a
novel
drug
delivery
system,
has
attracted
widespread
attention
due
to
its
non-invasiveness,
painless
and
simple
administration,
controllable
delivery,
diverse
cargo
loading
capacity.
Although
microneedles
are
initially
designed
penetrate
stratum
corneum
of
skin
for
transdermal
they,
recently,
have
been
used
promote
wound
healing
regeneration
tissues
organs
the
results
promising.
Despite
there
reviews
about
microneedles,
few
them
focus
on
tissue
regeneration.
Here,
we
review
recent
advances
in
this
field.
We
first
give
an
overview
microneedle
system
terms
potential
cargos
(e.g.,
small
molecules,
macromolecules,
nucleic
acids,
nanoparticles,
extracellular
vesicle,
cells),
structural
designs
multidrug
structures,
adhesive
structures),
material
selection,
release
mechanisms.
Then
briefly
summarize
different
fabrication
methods,
including
their
advantages
limitations.
finally
progress
microneedle-assisted
skin,
cardiac,
bone,
tendon,
ocular,
vascular,
oral,
hair,
spinal
cord,
uterine
tissues).
expect
that
our
article
would
serve
guideline
readers
design
systems
according
applications,
structure
design,
achieving
better
efficacy.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(13)
Published: Feb. 5, 2023
Abstract
Myocardial
infarction
(MI)
is
a
cardiovascular
disease
that
poses
serious
threat
to
human
health.
Uncontrolled
and
excessive
cardiac
fibrosis
after
MI
has
been
recognized
as
primary
contributor
mortality
by
heart
failure.
Thus,
prevention
of
or
alleviation
progression
important
for
repair.
To
this
end,
biocompatible
microneedle
(MN)
patch
based
on
gelatin
fabricated
load
exosomes
containing
microRNA‐29b
(miR‐29b)
mimics
with
antifibrotic
activity
prevent
MI.
Exosomes
are
isolated
from
umbilical
cord
mesenchymal
stem
cells
loaded
miR‐29b
via
electroporation,
which
can
be
internalized
effectively
in
fibroblasts
upregulate
the
expression
downregulate
fibrosis‐related
proteins.
After
being
implanted
infarcted
mouse
model,
MN
increase
retention
myocardium,
leading
inflammation,
reduction
infarct
size,
inhibition
fibrosis,
improvement
function.
This
design
explored
suitable
platform
deliver
biomolecules
locally
showing
potential
treatment
clinical
applications.
Small,
Journal Year:
2023,
Volume and Issue:
19(51)
Published: March 22, 2023
The
rapid
development
of
wearable
biosensing
calls
for
next-generation
devices
that
allow
continuous,
real-time,
and
painless
monitoring
health
status
along
with
responsive
medical
treatment.
Microneedles
have
exhibited
great
potential
the
direct
access
dermal
interstitial
fluid
(ISF)
in
a
minimally
invasive
manner.
Recent
studies
microneedle-based
evolved
from
conventional
off-line
detection
to
multiplexed,
wireless,
integrated
sensing.
In
this
review,
classification
fabrication
techniques
microneedles
are
first
introduced,
then
representative
examples
transdermal
different
sensing
modalities
summarized.
State-of-the-art
advances
therapeutic
closed-loop
systems
presented
formulate
guidelines
healthcare
platforms.
challenges
prospects
discussed
pave
new
avenue
toward
pragmatic
applications
real
world.
ACS Sensors,
Journal Year:
2023,
Volume and Issue:
8(3), P. 1241 - 1251
Published: Feb. 23, 2023
Continuous
glucose
monitoring
(CGM)
can
mini-invasively
track
blood
fluctuation
and
reduce
the
risk
of
hyperglycemia
hypoglycemia,
this
is
in
great
demand
for
diabetes
management.
However,
cost-effective
manufacture
CGM
systems
with
continuously
improved
convenience
performance
still
persistent
goal.
Herein,
we
developed
a
smartphone-controlled
microneedle
(MN)-based
wearable
system
long-term
monitoring.
The
modified
sandwich-type
enzyme
immobilization
strategy
satisfy
clinical
requirement
interstitial
fluid
(ISF)
14
days
mean
absolute
relative
difference
10.2%
cost
less
than
$15,
which
correlated
well
commercial
glucometer
FDA-approved
FreeStyle
Libre
(Abbott
Inc.,
Illinois,
USA).
self-developed
demonstrated
to
accurately
monitor
fluctuations
provide
abundant
information.
It
better
find
cause
individual
changes
beneficial
guide
precise
control.
On
whole,
intelligently
may
an
alternative
solution
home-care
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(5), P. 2567 - 2574
Published: May 2, 2024
In
vivo
drug
monitoring
is
crucial
for
evaluating
the
effectiveness
and
safety
of
treatment.
Blood
sampling
analysis
current
gold
standard
but
needs
professional
skills
cannot
meet
requirements
point-of-care
testing.
Dermal
interstitial
fluid
(ISF)
showed
great
potential
to
replace
blood
in
monitoring;
however,
detection
was
challenging,
distribution
behavior
ISF
still
unclear
until
now.
this
study,
we
proposed
surface-enhanced
Raman
spectroscopy
(SERS)
microneedles
(MNs)
painless
real-time
drugs
after
intravenous
injection.
Using
methylene
blue
(MB)
mitoxantrone
(MTO)
as
model
drugs,
innovative
core–satellite
structured
Au@Ag
SERS
substrate,
hydrogel
coating
over
MNs,
rendered
sensitive
quantitative
mice
within
10
min.
Based
on
technique,
pharmacokinetics
two
investigated
compared
with
those
blood,
where
were
analyzed
via
liquid
chromatography–mass
spectrometry.
It
found
that
MB
concentration
comparable,
whereas
MTO
2–3
orders
magnitude
lower
than
blood.
This
work
an
efficient
tool
monitoring.
More
importantly,
it
experimentally
proved
penetration
ratio
drug-dependent,
providing
insightful
information
into
a
alternative
detection.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Abstract
Theranostics,
combining
therapeutic
and
diagnostic
functions,
marks
a
revolutionary
advancement
in
modern
medicine,
with
microneedle
technology
at
its
forefront.
This
review
explores
the
substantial
developments
multifaceted
applications
of
microneedles,
which
have
evolved
from
basic
transdermal
drug
delivery
devices
to
sophisticated
platforms.
Microneedles
enhance
access
biomarkers
via
interstitial
fluid,
enabling
real‐time
monitoring
physiological
conditions,
such
as
glucose
hormone
levels,
thus
facilitating
continuous
health
tracking.
The
evolution
design
solid
dissolvable
forms
broadens
their
utility
mere
complex
sensing
applications,
including
insulin
for
diabetes
management,
vaccination,
gene
therapy.
paper
delves
into
integration
microneedles
wearable
technologies,
highlighting
role
closed‐loop
systems
that
combine
dynamic,
precise
delivery.
By
addressing
gaps
literature
regarding
integrated
treatment
capabilities,
this
underscores
pivotal
personalizing
medicine.
It
concludes
visionary
perspective
on
future
trajectory
technology,
emphasizing
potential
revolutionize
strategies
through
enhanced
efficacy,
safety,
patient
compliance.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(21)
Published: March 22, 2023
Abstract
Point‐of‐care
testing
(POCT)
of
clinical
biomarkers
is
critical
to
health
monitoring
and
timely
treatment,
yet
biosensing
assays
capable
detecting
without
the
need
for
costly
external
equipment
reagents
are
limited.
Blood‐based
are,
specifically,
challenging
as
blood
collection
invasive
follow‐upprocessing
required.
Here,
we
report
a
versatile
assay
that
employs
hydrogel
microneedles
(HMNs)
extract
interstitial
fluid
(ISF),
in
minimally
manner
integrated
with
graphene
oxide‐nucleic
acid
(GO.NA)‐based
fluorescence
biosensor
sense
interest
situ.
The
HMN‐GO.NA
supplemented
portable
detector,
enabling
complete
POCT
procedure.
Our
system
could
successfully
measure
four
clinically
important
(glucose,
uric
(UA),
insulin,
serotonin)
ex
vivo,
addition,
accurately
glucose
UA
vivo.
ACS Sensors,
Journal Year:
2023,
Volume and Issue:
8(11), P. 4161 - 4170
Published: Oct. 19, 2023
Wearable
devices
based
on
microneedle
(MN)
technology
have
recently
emerged
as
tools
for
in
situ
transdermal
sensing
or
delivery
interstitial
fluid
(ISF).
Particularly,
MN-based
electrochemical
sensors
allow
the
continuous
monitoring
of
analytes
a
minimally
invasive
manner
through
ISF.
Exogenous
small
molecules
found
ISF
such
therapeutic
drugs
are
ideal
candidates
MN
due
to
their
correlation
with
blood
levels
and
relevance
optimal
management
personalized
therapies.
Herein,
hollow
array
patch
is
modified
conductive
pastes
functionalized
cross-linked
chitosan
develop
an
voltammetric
sensor
methotrexate
(MTX).
Interestingly,
coating
avoids
biofouling
while
enabling
adsorption
MTX
at
electrode's
surface
sensitive
analysis.
The
exhibits
excellent
analytical
performance
vitro
protein-enriched
artificial
ex
vivo
under
Franz
diffusion
cell
configuration.
shows
linear
range
from
25
400
μM,
which
fits
within
high-dose
treatment
cancer
patients
operation
more
than
two
days.
Moreover,
iontophoretic
developed
integration
both
anode
cathode
single
patch.
characterization
demonstrates
on-demand
drug
MTX.
Overall,
combination
patches
represents
impactful
progress
closed-loop
systems
disorders
cancer,
rheumatoid
arthritis,
psoriasis.
