Applied Materials Today, Journal Year: 2022, Volume and Issue: 29, P. 101659 - 101659
Published: Oct. 18, 2022
Language: Английский
Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 303 - 326
Published: April 18, 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable delivery, diverse cargo loading capacity. Although microneedles are initially designed penetrate stratum corneum of skin for transdermal they, recently, have been used promote wound healing regeneration tissues organs the results promising. Despite there reviews about microneedles, few them focus on tissue regeneration. Here, we review recent advances in this field. We first give an overview microneedle system terms potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs multidrug structures, adhesive structures), material selection, release mechanisms. Then briefly summarize different fabrication methods, including their advantages limitations. finally progress microneedle-assisted skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, uterine tissues). expect that our article would serve guideline readers design systems according applications, structure design, achieving better efficacy.
Language: Английский
Citations
135
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(13)
Published: Feb. 5, 2023
Abstract Myocardial infarction (MI) is a cardiovascular disease that poses serious threat to human health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as primary contributor mortality by heart failure. Thus, prevention of or alleviation progression important for repair. To this end, biocompatible microneedle (MN) patch based on gelatin fabricated load exosomes containing microRNA‐29b (miR‐29b) mimics with antifibrotic activity prevent MI. Exosomes are isolated from umbilical cord mesenchymal stem cells loaded miR‐29b via electroporation, which can be internalized effectively in fibroblasts upregulate the expression downregulate fibrosis‐related proteins. After being implanted infarcted mouse model, MN increase retention myocardium, leading inflammation, reduction infarct size, inhibition fibrosis, improvement function. This design explored suitable platform deliver biomolecules locally showing potential treatment clinical applications.
Language: Английский
Citations
90
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(4), P. 324 - 342
Published: Dec. 21, 2023
Language: Английский
Citations
83
Small, Journal Year: 2023, Volume and Issue: 19(51)
Published: March 22, 2023
The rapid development of wearable biosensing calls for next-generation devices that allow continuous, real-time, and painless monitoring health status along with responsive medical treatment. Microneedles have exhibited great potential the direct access dermal interstitial fluid (ISF) in a minimally invasive manner. Recent studies microneedle-based evolved from conventional off-line detection to multiplexed, wireless, integrated sensing. In this review, classification fabrication techniques microneedles are first introduced, then representative examples transdermal different sensing modalities summarized. State-of-the-art advances therapeutic closed-loop systems presented formulate guidelines healthcare platforms. challenges prospects discussed pave new avenue toward pragmatic applications real world.
Language: Английский
Citations
61
ACS Sensors, Journal Year: 2023, Volume and Issue: 8(3), P. 1241 - 1251
Published: Feb. 23, 2023
Continuous glucose monitoring (CGM) can mini-invasively track blood fluctuation and reduce the risk of hyperglycemia hypoglycemia, this is in great demand for diabetes management. However, cost-effective manufacture CGM systems with continuously improved convenience performance still persistent goal. Herein, we developed a smartphone-controlled microneedle (MN)-based wearable system long-term monitoring. The modified sandwich-type enzyme immobilization strategy satisfy clinical requirement interstitial fluid (ISF) 14 days mean absolute relative difference 10.2% cost less than $15, which correlated well commercial glucometer FDA-approved FreeStyle Libre (Abbott Inc., Illinois, USA). self-developed demonstrated to accurately monitor fluctuations provide abundant information. It better find cause individual changes beneficial guide precise control. On whole, intelligently may an alternative solution home-care
Language: Английский
Citations
53
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 115 - 130
Published: Feb. 21, 2024
Language: Английский
Citations
21
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(5), P. 2567 - 2574
Published: May 2, 2024
In vivo drug monitoring is crucial for evaluating the effectiveness and safety of treatment. Blood sampling analysis current gold standard but needs professional skills cannot meet requirements point-of-care testing. Dermal interstitial fluid (ISF) showed great potential to replace blood in monitoring; however, detection was challenging, distribution behavior ISF still unclear until now. this study, we proposed surface-enhanced Raman spectroscopy (SERS) microneedles (MNs) painless real-time drugs after intravenous injection. Using methylene blue (MB) mitoxantrone (MTO) as model drugs, innovative core–satellite structured Au@Ag SERS substrate, hydrogel coating over MNs, rendered sensitive quantitative mice within 10 min. Based on technique, pharmacokinetics two investigated compared with those blood, where were analyzed via liquid chromatography–mass spectrometry. It found that MB concentration comparable, whereas MTO 2–3 orders magnitude lower than blood. This work an efficient tool monitoring. More importantly, it experimentally proved penetration ratio drug-dependent, providing insightful information into a alternative detection.
Language: Английский
Citations
21
Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5
Published: Jan. 1, 2024
Personalized pain medicine aims to tailor treatment strategies for the specific needs and characteristics of an individual patient, holding potential improving outcomes, reducing side effects, enhancing patient satisfaction. Despite existing markers treatments, challenges remain in understanding, detecting, treating complex conditions. Here, we review recent engineering efforts developing various sensors devices addressing personalized pain. We summarize basics pathology introduce monitoring, assessment, relief. also discuss advancements taking advantage rapidly medical artificial intelligence (AI), such as AI-based analgesia devices, wearable sensors, healthcare systems. believe that these innovative technologies may lead more precise responsive medicine, greatly improved quality life, increased efficiency systems, incidence addiction substance use disorders.
Language: Английский
Citations
18
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Abstract Theranostics, combining therapeutic and diagnostic functions, marks a revolutionary advancement in modern medicine, with microneedle technology at its forefront. This review explores the substantial developments multifaceted applications of microneedles, which have evolved from basic transdermal drug delivery devices to sophisticated platforms. Microneedles enhance access biomarkers via interstitial fluid, enabling real‐time monitoring physiological conditions, such as glucose hormone levels, thus facilitating continuous health tracking. The evolution design solid dissolvable forms broadens their utility mere complex sensing applications, including insulin for diabetes management, vaccination, gene therapy. paper delves into integration microneedles wearable technologies, highlighting role closed‐loop systems that combine dynamic, precise delivery. By addressing gaps literature regarding integrated treatment capabilities, this underscores pivotal personalizing medicine. It concludes visionary perspective on future trajectory technology, emphasizing potential revolutionize strategies through enhanced efficacy, safety, patient compliance.
Language: Английский
Citations
2
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 16, 2025
Abstract The thriving of internet things and mobile healthcare requires a myriad sensing devices for continuous implantable wearable monitoring over extended periods. However, lack biocompatibility degradability has become bottleneck rehabilitation close‐loop diagnosis therapy as well in‐vivo biomonitoring platforms. Herein, an biodegradable smart textile (IBST) composed natural loofah sponge is reported, carbon ink, silver nanoparticles. Combining finite element analysis experimental characterization, optimal performance achieved, featuring high sensitivity (4.023 [kPa] −1 ) good linearity (R 2 = 0.995) across wide range (0–50 kPa), with response time 88 ms pressure detection. Through the construction training neural network model, prepared IBSTs enable effective identification evaluation force exertion patterns simulated Parkinson's patients at different stages wearer's motion states. Moreover, accurate gastric motility realized by implanting IBPS into rats’ stomach, validating excellent biodegradability. This work opens up new paradigm next‐generation medical advanced electronics.
Language: Английский
Citations
2