Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(6)
Published: May 23, 2022
Immunotherapy
is
used
to
regulate
systemic
hyperactivation
or
hypoactivation
treat
various
diseases.
Biomaterial-based
immunotherapy
systems
can
improve
therapeutic
effects
through
targeted
drug
delivery,
immunoengineering,
etc.
However,
the
immunomodulatory
of
biomaterials
themselves
cannot
be
neglected.
In
this
review,
we
outline
with
functions
discovered
in
recent
years
and
their
applications
disease
treatment.
These
inflammation,
tumors,
autoimmune
diseases
by
regulating
immune
cell
function,
exerting
enzyme-like
activity,
neutralizing
cytokines,
The
prospects
challenges
biomaterial-based
modulation
are
also
discussed.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
13(2), P. 345 - 364
Published: Dec. 16, 2021
This
review
surveys
the
structure–activity
of
advanced
antimicrobial
cationic
polymers
with
low
toxicity
and
high
selectivity.
Their
uses
as
potentiating
adjuvants
antibiofilm
agents
are
also
covered.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(2), P. 351 - 351
Published: Jan. 17, 2022
The
search
for
higher-quality
nanomaterials
medicinal
applications
continues.
There
are
similarities
between
electrospun
fibers
and
natural
tissues.
This
property
has
enabled
to
make
significant
progress
in
medical
applications.
However,
limited
tissue
scaffolding
When
nanoparticles
nanofibers
combined,
the
composite
material
can
perform
more
functions,
such
as
photothermal,
magnetic
response,
biosensing,
antibacterial,
drug
delivery
biosensing.
To
prepare
nanofiber
nanoparticle
hybrids
(NNHs),
there
two
primary
ways.
electrospinning
technology
was
used
produce
NNHs
a
single
step.
An
alternate
way
is
use
self-assembly
technique
create
fibers.
paper
describes
creation
of
from
routinely
biocompatible
polymer
composites.
Single-step
procedures
methodologies
discuss
preparation
NNHs.
It
combines
recent
research
discoveries
focus
on
application
release,
engineering
last
years.
ACS Applied Bio Materials,
Journal Year:
2022,
Volume and Issue:
5(2), P. 366 - 393
Published: Jan. 24, 2022
Bacterial
resistance
caused
by
the
overuse
of
antibiotics
and
shelter
biofilms
has
evolved
into
a
global
health
crisis,
which
drives
researchers
to
continuously
explore
antimicrobial
molecules
strategies
fight
against
drug-resistant
bacteria
biofilm-associated
infections.
Cationic
peptides
(AMPs)
are
considered
be
category
potential
alternative
for
owing
their
excellent
bactericidal
potency
lesser
likelihood
inducing
drug
through
distinctive
mechanisms.
In
this
review,
hitherto
reported
plentiful
action
modes
AMPs
systematically
classified
15
types
three
categories
(membrane
destructive,
nondestructive
membrane
disturbance,
intracellular
targeting
mechanisms).
Besides
natural
AMPs,
cationic
polypeptides,
synthetic
polymers,
biopolymers
enable
achieve
tunable
properties
optimizing
structures.
Subsequently,
applications
these
agents
at
biointerface
as
contact-active
surface
coatings
multifunctional
wound
dressings
also
emphasized
here.
At
last,
we
provide
our
perspectives
on
development
clinically
significant
antimicrobials
related
challenges
in
translation
materials.
Small,
Journal Year:
2023,
Volume and Issue:
19(17)
Published: Jan. 29, 2023
Hydrogels
have
extremely
high
moisture
content,
which
makes
it
very
soft
and
excellently
biocompatible.
They
become
an
important
material
a
wide
range
of
applications
in
various
fields
such
as
biomedicine,
bionic
smart
material,
electrochemistry.
Carbon
dot
(CD)-based
hydrogels
are
based
on
carbon
dots
(CDs)
auxiliary
substances,
forming
gel
with
comprehensive
properties
individual
components.
CDs
embedding
could
not
only
solve
their
aggregation-caused
quenching
(ACQ)
effect,
but
also
manipulate
the
even
bring
some
novel
properties,
achieving
win-win
situation.
In
this
review,
preparation
methods,
formation
mechanism,
CD-based
hydrogels,
sensing,
adsorption,
energy
storage,
catalysis
-are
summarized.
Finally,
brief
discussion
future
research
directions
will
be
given.
Materials,
Journal Year:
2023,
Volume and Issue:
16(15), P. 5459 - 5459
Published: Aug. 3, 2023
The
treatment
of
skin
wounds
caused
by
trauma
and
pathophysiological
disorders
has
been
a
growing
healthcare
challenge,
posing
great
economic
burden
worldwide.
use
appropriate
wound
dressings
can
help
to
facilitate
the
repair
healing
rate
defective
skin.
Natural
polymer
biomaterials
such
as
collagen
hyaluronic
acid
with
excellent
biocompatibility
have
shown
promote
restoration
However,
low
mechanical
properties
fast
degradation
limited
their
applications.
Skin
based
on
biodegradable
biocompatible
synthetic
polymers
not
only
overcome
shortcomings
natural
but
also
possess
favorable
for
applications
in
wounds.
Herein,
we
listed
several
used
dressing
materials,
PVA,
PCL,
PLA,
PLGA,
PU,
PEO/PEG,
focusing
composition,
fabrication
techniques,
functions
promoting
healing.
Additionally,
future
development
prospects
polymer-based
are
put
forward.
Our
review
aims
provide
new
insights
further
using
polymers.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(9), P. 3051 - 3076
Published: Jan. 1, 2023
This
review
offers
systematic
considerations
of
material
design
principles
and
fabrication
techniques
for
biomimetic
skin
tissue
engineering
scaffolds.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
The
global
increase
of
cutaneous
wounds
imposes
huge
health
and
financial
burdens
on
patients
society.
Despite
improved
wound
healing
outcomes,
conventional
dressings
are
far
from
ideal,
owing
to
the
complex
process.
Smart
dressings,
which
sensitive
or
interact
with
changes
in
condition
environment,
have
been
proposed
as
appealing
therapeutic
platforms
effectively
facilitate
healing.
In
this
review,
processes
features
existing
biomaterials
firstly
introduced,
followed
by
summarizing
mechanisms
smart
responsive
materials.
Afterwards,
recent
advances
designs
versatile
materials
extensive
applications
for
were
submarined.
Finally,
clinical
progresses,
challenges
future
perspectives
dressing
discussed.
Overall,
mapping
composition
intrinsic
structure
their
individual
needs
wounds,
particular
attention
mechanisms,
review
is
promising
advance
further
progress
designing
drive
translation.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Textiles
have
played
a
pivotal
role
in
human
development,
evolving
from
basic
fibers
into
sophisticated,
multifunctional
materials.
Advances
material
science,
nanotechnology,
and
electronics
propelled
next-generation
textiles
beyond
traditional
functionalities,
unlocking
innovative
possibilities
for
diverse
applications.
Thermal
management
incorporate
ultralight,
ultrathin
insulating
layers
adaptive
cooling
technologies,
optimizing
temperature
regulation
dynamic
extreme
environments.
Moisture
utilize
advanced
structures
unidirectional
transport
breathable
membranes,
ensuring
exceptional
comfort
activewear
outdoor
gear.
Protective
exhibit
enhanced
features,
including
antimicrobial,
antiviral,
anti-toxic
gas,
heat-resistant,
radiation-shielding
capabilities,
providing
high-performance
solutions
healthcare,
defense,
hazardous
industries.
Interactive
integrate
sensors
monitoring
physical,
chemical,
electrophysiological
parameters,
enabling
real-time
data
collection
responses
to
various
environmental
user-generated
stimuli.
Energy
leverage
triboelectric,
piezoelectric,
hygroelectric
effects
improve
energy
harvesting
storage
wearable
devices.
Luminous
display
textiles,
electroluminescent
fiber
optic
systems,
enable
visual
applications
fashion
communication.
These
advancements
position
at
the
forefront
of
materials
significantly
expanding
their
potential
across
wide
range
Macromolecular Chemistry and Physics,
Journal Year:
2022,
Volume and Issue:
224(3)
Published: Aug. 12, 2022
Abstract
Antibiotic
resistance
has
become
a
critical
issue,
alarming
the
healthcare
and
agriculture
sectors
worldwide.
Thanks
to
rapid
advancements
in
polymer
science,
antimicrobial
polymers
(AMPs)
have
been
developed
as
mimic
version
of
host‐defense
peptides
(a
part
natural
immune
systems
multicellular
organisms)
mitigate
antibiotic
resistance.
By
exploiting
advanced
polymerization
techniques,
structures
are
easily
manipulated
well‐defined
controlled
manner,
enabling
precise
accurate
evaluation
structure–activity
relationship.
Recent
years
witnessed
blossoming
development.
This
review
provides
comprehensive
insight
into
from
concept
structure
design,
biofunction
control.
Along
with
optimization
intrinsic
factors,
including
compositional
topological
features,
external
factors
like
induced
conformation
upon
exposure
specific
targeting
pathogens
should
be
considered
AMP
design
optimization.
Furthermore,
new
approaches
smart
response
platforms
(or
bacterial‐induced
triggering
systems)
administration
dosage
forms
for
also
discussed
prospective
strategies
address
remaining
challenge
toxicity
while
maintaining
or
even
enhancing
potency.
