ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(42), P. 48952 - 48962
Published: Oct. 16, 2023
Excessive
oxidative
stress,
bacterial
infections,
and
inflammation
are
the
primary
factors
impeding
healing
of
skin
wounds.
Bioactive
hydrogels
commonly
employed
in
treatment
injuries.
However,
limited
solubility
many
drugs
active
agents
water
significantly
hampers
their
effectiveness
hydrogel
dressings.
In
this
research,
prior
to
incorporation
into
silk
fibroin
(SF)
matrix,
two
curcumin
silver
nanoparticles
(Ag
NPs)
were
decorated
by
sericin
improve
dispersibility
stability
water.
The
resultant
SF/Ag/C
combined
biological
safety
nontoxicity
SF,
antioxidant
anti-inflammatory
efficacy
curcumin,
antibacterial
effect
Ag
NPs.
These
properties
effectively
enhanced
wound
repair
reducing
mitigating
suppressing
expression
pro-inflammatory
factors,
promoting
angiogenesis.
This
study
presented
a
straightforward
approach
for
constructing
bioactive
promotion
process.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Progress in Materials Science,
Journal Year:
2024,
Volume and Issue:
147, P. 101350 - 101350
Published: Aug. 6, 2024
Wound
healing
is
a
complex
biological
process
that,
when
impaired,
can
lead
to
the
formation
of
scars.
Electrospun
nanofibrous
wound
dressings
have
emerged
as
promising
option
for
promoting
scar-free
healing.
This
paper
explores
role
physical,
compositional,
and
chemical
cues,
each
contributing
remarkable
potential
these
dressings.
The
physical
properties
dressings,
such
porosity
mechanical
characteristics,
guide
cellular
behaviors
promote
vascularization,
fostering
conducive
environment
reduced
scarring.
Furthermore,
integration
natural
polymers
that
mimic
skin's
extracellular
matrix,
known
compositional
adds
another
layer
complexity
As
therapeutic
agents
demonstrated
their
combat
chronic
scenarios
leading
scar
formation.
However,
achieving
desired
effect
hinges
on
nature
controlled
release.
Therefore,
also
delves
into
various
loading
techniques
tailoring
release
profiles
bioactive
agents.
Although
electrospun
are
viable
commercial
product
remains
elusive.
gap
be
attributed
lack
comprehensive
in
vivo
studies,
particularly
animal
models
human
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(27)
Published: March 7, 2024
Abstract
In
vitro
skin
models
are
validated
methods
for
screening
cosmetics
and
pharmaceuticals,
but
still
have
limitations.
The
bilayer
poly(ε‐caprolactone)
scaffold/membrane
model
described
here
overcomes
some
of
these
deficits
by
integrating
a
solution
electrospun
(SES)
membrane
at
the
dermoepidermal
interface
melt
electrowritten
(MEW)
scaffold
that
provides
an
optimal
open‐pore
environment
dermis.
To
knowledge,
this
is
only
one
capable
creating
properly
differentiated,
full
thickness
with
neosynthesized
extracellular
matrix
(ECM)
in
18
days.
Both
wavy
straight
fiber
designs
create
well‐organized
dermis,
dermal
collagen
organization
differs
between
designs.
Adding
cells
vitamin
C
to
scaffolds
improves
mechanical
properties
more
closely
mimic
native
human
skin.
These
findings
establish
bicomponent
as
promising
advancement
rapidly
different
varied
properties.
versatility
adaptability
can
be
used
studying
how
biological
physical
microenvironment
impact
skin,
testing
dermo‐cosmetics
pharmaceutical
treatments
on
ages
Furthermore,
it
excellent
new
tool
wound
healing
development
into
its
use
graft
or
dressing
ongoing.
Gels,
Journal Year:
2023,
Volume and Issue:
9(5), P. 431 - 431
Published: May 22, 2023
Silk
fibroin
(SF)
is
an
excellent
protein-based
biomaterial
produced
by
the
degumming
and
purification
of
silk
from
cocoons
Bombyx
mori
through
alkali
or
enzymatic
treatments.
SF
exhibits
biological
properties,
such
as
mechanical
biocompatibility,
biodegradability,
bioabsorbability,
low
immunogenicity,
tunability,
making
it
a
versatile
material
widely
applied
in
fields,
particularly
tissue
engineering.
In
engineering,
often
fabricated
into
hydrogel
form,
with
advantages
added
materials.
hydrogels
have
mostly
been
studied
for
their
use
regeneration
enhancing
cell
activity
at
defect
site
counteracting
tissue-damage-related
factors.
This
review
focuses
on
hydrogels,
firstly
summarizing
fabrication
properties
then
detailing
regenerative
effects
scaffolds
cartilage,
bone,
skin,
cornea,
teeth,
eardrum
recent
years.
Nano Materials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
The
field
of
photocatalysis
has
witnessed
a
significant
advancement
in
the
development
bioinspired
and
biomimetic
photocatalysts
for
various
biomedical
applications,
including
drug
delivery,
tissue
engineering,
cancer
therapy,
bioimaging.
Nature
evolved
efficient
light-harvesting
systems
energy
conversion
mechanisms,
which
serve
as
benchmark
researchers.
However,
reproducing
such
complexity
harnessing
it
applications
is
daunting
task.
It
requires
comprehensive
understanding
underlying
biological
processes
ability
to
replicate
them
synthetically.
By
utilizing
light
energy,
these
can
trigger
specific
chemical
reactions,
leading
targeted
release,
enhanced
regeneration,
precise
imaging
structures.
In
this
context,
addressing
stability,
long-term
performance,
scalability,
cost-effectiveness
materials
crucial
their
widespread
implementation
applications.
While
challenges
stability
persist,
advantages
delivery
personalized
medicine
make
fascinating
area
research.
purpose
review
provide
analysis
evaluation
existing
research,
highlighting
advancements,
current
challenges,
advantages,
limitations,
future
prospects
biomedicine.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(5), P. 278 - 278
Published: May 7, 2024
Biomimetic
materials
have
become
a
promising
alternative
in
the
field
of
tissue
engineering
and
regenerative
medicine
to
address
critical
challenges
wound
healing
skin
regeneration.
Skin-mimetic
enormous
potential
improve
outcomes
enable
innovative
diagnostic
sensor
applications.
Human
skin,
with
its
complex
structure
diverse
functions,
serves
as
an
excellent
model
for
designing
biomaterials.
Creating
effective
coverings
requires
mimicking
unique
extracellular
matrix
composition,
mechanical
properties,
biochemical
cues.
Additionally,
integrating
electronic
functionality
into
these
presents
exciting
possibilities
real-time
monitoring,
diagnostics,
personalized
healthcare.
This
review
examines
biomimetic
their
role
healing,
well
integration
technologies.
It
discusses
recent
advances,
challenges,
future
directions
this
rapidly
evolving
field.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Burn
care
and
treatment
differ
markedly
from
other
types
of
wounds,
as
they
are
significantly
more
prone
to
infections
struggle
maintain
fluid
balance
post-burn.
Moreover,
the
limited
self-healing
abilities
exacerbate
likelihood
scar
formation,
further
complicating
recovery
process.
To
tackle
these
issues,
an
asymmetric
wound
dressing
comprising
a
quercetin-loaded
poly(3-hydroxybutyrate-co-4-hydroxybutyrate)
(P34HB@Qu)
hydrophilic
layer
zinc
oxide
nanoparticle-loaded,
thermally
treated
polyvinylidene
fluoride
(HPVDF@ZnO)
hydrophobic
is
designed.
This
provided
antibacterial
property
exudate
management
in
early
stages
burn
treatment,
preventing
infection
maintaining
moisture
at
site.
As
healing
progresses,
electroactive
properties
HPVDF@ZnO
quercetin
P34HB@Qu
synergistically
regulate
cell
migration
differentiation,
accelerating
facilitating
scar-free
regeneration.
Furthermore,
assisted
regeneration
skin
appendages.
study
underscores
full-cycle
strategy
versatile
dressings
for
spatiotemporal
injury
scarless
healing.
