Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(3), P. 430 - 430
Published: March 21, 2024
Hydrogels
with
injectability
have
emerged
as
the
focal
point
in
tissue
filling,
owing
to
their
unique
properties,
such
minimal
adverse
effects,
faster
recovery,
good
results,
and
negligible
disruption
daily
activities.
These
hydrogels
could
attain
through
chemical
covalent
crosslinking,
physical
or
biological
crosslinking.
reactions
allow
for
formation
of
reversible
bonds
delayed
gelatinization,
ensuring
a
minimally
invasive
approach
filling.
Injectable
facilitate
augmentation
regeneration
by
offering
slow
degradation,
mechanical
support,
modulation
functions
host
cells.
This
review
summarizes
recent
advancements
synthetic
strategies
injectable
introduces
application
Ultimately,
we
discuss
prospects
prevailing
challenges
developing
optimal
augmentation,
aiming
chart
course
future
investigations.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(9), P. 4054 - 4077
Published: April 18, 2024
Stimuli-responsive
self-immolative
polymers
(SIPs)
represent
a
unique
class
of
that
can
undergo
controlled,
sequential
head-to-tail
depolymerization
upon
specific
stimuli.
Since
their
inception,
they
have
evolved
over
two
decades
to
become
one
the
most
attractive
polymer
types.
With
characteristic
feature
"one
stimulus,
multiple
responses",
SIPs
inherently
possess
ability
serve
as
chemical
amplifiers,
which
amplify
weak
or
biological
signals.
This
promises
higher
stimulus
sensitivity,
greater
selectivity
for
microenvironments,
and
potential
generate
more
persistent,
extensive,
significant
responses
while
consuming
fewer
stimuli
sources.
Review
summarizes
latest
research
advancements
in
stimuli-responsive
drug
delivery
molecular
imaging
past
five
years.
Regarding
structure
SIPs,
we
briefly
overview
updates
self-immolation
units,
end-cap
moieties,
sequence
SIPs.
In
terms
applications,
focus
on
possible
applications
disease
treatment
methods.
Finally,
provide
brief
perspective
future
directions
these
applications.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(16)
Published: Jan. 3, 2024
Abstract
The
foundation
of
regenerative
medicine
is
the
investigation
and
progression
hypotheses
approaches
for
substituting,
mending,
reconstructing,
or
regenerating
different
tissues
organs
within
human
body.
Nevertheless,
due
to
slender
central
segment
entire
unattached
configuration
meniscus,
efficacy
conventional
therapies
unsatisfactory
in
reinstating
meniscal
health
functionality.
To
overcome
these
limitations,
medical‐type
hydrogels
have
potential
provide
a
solution
meniscus
repair
regeneration.
Their
biocompatibility
modifiability
enable
safe
implantations
vivo,
effectively
modifying
pathophysiology
cells
surrounding
microenvironment
at
site
injury.
This
article
reviews
usage
implantable
regeneration
repair.
First,
structure
physiologic
function
are
first
briefly
described.
Following
this,
use
varying
highlighted,
alongside
discussion
materials
employed
constructing
hydrogel
implants.
Lastly,
an
analysis
issues
challenges
associated
with
presented.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1197 - 1197
Published: Sept. 11, 2024
The
clustered
regularly
interspaced
short
palindromic
repeat
(CRISPR)/Cas9
system
is
a
gene-editing
technology.
Nanoparticle
delivery
systems
have
attracted
attention
because
of
the
limitations
conventional
viral
vectors.
In
this
review,
we
assess
efficiency
various
nanoparticles,
including
lipid-based,
polymer-based,
inorganic,
and
extracellular
vesicle-based
systems,
as
non-viral
vectors
for
CRISPR/Cas9
delivery.
We
discuss
their
advantages,
limitations,
current
challenges.
By
summarizing
recent
advancements
highlighting
key
strategies,
review
aims
to
provide
comprehensive
overview
role
in
advancing
technology
clinical
applications
gene
therapy.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
