Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(6), P. 834 - 845

Published: Feb. 21, 2024

Language: Английский

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Aggregation‐Induced Emission‐Based Macrophage‐Like Nanoparticles for Targeted Photothermal Therapy and Virus Transmission Blockage in Monkeypox

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Nov. 6, 2023

The recent prevalence of monkeypox has led to the declaration a Public Health Emergency International Concern. Monkeypox lesions are typically ulcers or pustules (containing high titers replication-competent virus) in skin and mucous membranes, which allow virus transmit predominantly through intimate contact. Currently, effective clinical treatments for lacking, strategies blocking transmission fraught with drawbacks. Herein, this work constructs biomimetic nanotemplate (termed TBD@M NPs) macrophage membranes as coat polymeric nanoparticles loading versatile aggregation-induced emission featured photothermal molecule TPE-BT-DPTQ core. In surrogate mouse model (vaccinia-virus-infected tail scarification model), intravenously injected NPs show precise tracking near-infrared region II fluorescence imaging lesions. Upon 808 nm laser irradiation, is eliminated by effect infected wound heals rapidly. More importantly, inoculation treated lesion tissue suspensions does not trigger infection inflammatory activation healthy mice, indicating successful blockage transmission. This study demonstrates first time theranostics using nanomedicine, may bring new insight into development viable strategy management trials.

Language: Английский

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Multifunctional AIE Nanosphere-Based “Nanobomb” for Trimodal Imaging-Guided Photothermal/Photodynamic/Pharmacological Therapy of Drug-Resistant Bacterial Infections

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4601 - 4618

Published: Feb. 24, 2023

Injudicious or inappropriate use of antibiotics has led to the prevalence drug-resistant bacteria, posing a huge menace global health. Here, self-assembled aggregation-induced emission (AIE) nanosphere (AIE-PEG1000 NPs) that simultaneously possesses near-infrared region II (NIR-II) fluorescence emissive, photothermal, and photodynamic properties is prepared using multifunctional AIE luminogen (AIE-4COOH). The AIE-PEG1000 NPs were encapsulated with teicoplanin (Tei) ammonium bicarbonate (AB) into lipid nanovesicles form laser-activated "nanobomb" (AIE-Tei@AB NVs) for multimodal theranostics bacterial infections. In vivo experiments validate enables high-performance NIR-II fluorescence, infrared thermal, ultrasound (AB decomposition during photothermal process produce numerous CO2/NH3 bubbles, which an efficient contrast agent) imaging multidrug-resistant bacteria-infected foci after intravenous administration AIE-Tei@AB NVs followed by 660 nm laser stimulation. highly features NVs, combined excellent pharmacological property rapidly released Tei bubble generation NV disintegration, collectively promote broad-spectrum eradication three clinically isolated bacteria strains rapid healing infected wounds. This imaging-guided synergistic therapeutic strategy can be extended superbugs.

Language: Английский

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“Trojan Horse” Phototheranostics: Fine‐Engineering NIR‐II AIEgen Camouflaged by Cancer Cell Membrane for Homologous‐Targeting Multimodal Imaging‐Guided Phototherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: May 11, 2023

Multimodal phototheranostics on the basis of a single molecule with one-for-all characteristics represents convenient approach for effective cancer treatment. In this report, versatile featured by aggregation-induced emission, namely DHTDP, synchronously enabling second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion is developed elaborate structural modulation. By camouflaging DHTDP nanoparticles cell membrane, resultant biomimetic exhibit significantly both facilitated delivery efficiency homologous targeting capability, afford precise imaging guidance maximize therapeutic outcomes in form NIR-II (FLI)-photoacoustic (PAI)-photothermal (PTI) trimodal imaging-guided therapy (PTT). This study presents first example multimodal loaded homogeneity-targeting thus brings new insight into exploration superior practical theranostics.

Language: Английский

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Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Language: Английский

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J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

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Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 425 - 445

Published: Sept. 8, 2023

Language: Английский

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A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 24, 2024

Abstract Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of Alzheimer’s disease (AD). However, precise AD therapy is unrealizable due to the lack dual-targeting function, poor BBB penetration, low imaging sensitivity. Here, we design a near-infrared-II aggregation-induced emission (AIE) nanotheranostic for therapy. The anti-quenching at 1350 nm accurately monitors in vivo penetration specifically binding with plaques. Triggered by reactive oxygen species (ROS), encapsulated therapeutic-type AIE molecules controllably released activate self-enhanced program. One inhibits Aβ fibrils formation, degrades fibrils, prevents reaggregation via multi-competitive interactions that verified computational analysis, which further alleviates inflammation. Another effectively scavenges ROS remodel cerebral redox balance enhances effect, together reversing neurotoxicity achieving effective behavioral cognitive improvements female mice model.

Language: Английский

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