NIR‐II AIE Luminogen‐Based Erythrocyte‐Like Nanoparticles with Granuloma‐Targeting and Self‐Oxygenation Characteristics for Combined Phototherapy of Tuberculosis

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 28, 2024

Abstract Tuberculosis, a fatal infectious disease caused by Mycobacterium tuberculosis ( M.tb ), is difficult to treat with antibiotics due drug resistance and short half‐life. Phototherapy represents promising alternative in combating . Exploring an intelligent material allowing effective treatment definitely appealing, yet significantly challenging task. Herein, all‐in‐one biomimetic therapeutic nanoparticle featured aggregation‐induced second near‐infrared emission, granuloma‐targeting, self‐oxygenation constructed, which can serve for prominent fluorescence imaging‐navigated combined phototherapy toward tuberculosis. After camouflaging the erythrocyte membrane, nanoparticles show prolonged blood circulation increased selective accumulation granuloma. Upon laser irradiation, loading photosensitizer of emission elevates production reactive oxygen species (ROS), causing damage death. The delivery relieve hypoxic granuloma microenvironment supports ROS generation during photodynamic therapy. Meanwhile, photothermal agent, Prussian blue nanoparticles, plays role good killing effect on Moreover, growth proliferation colonies are effectively inhibited nanoparticle‐treated tuberculous model mice, suggesting effects enhancing therapy

Language: Английский

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Functional probes for the diagnosis and treatment of infectious diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for research treatment of infectious diseases. Their applications in realm include pathogen detection, exploration biological mechanisms, development anti‐infective drugs. This review provides a concise introduction severity, classification, pathogenesis Subsequently, we examined distinctiveness design strategies diagnosing treating diseases, shedding light on their rationale using typical examples. We discuss current status associated with clinical implementation probes. Furthermore, explored prospects these diagnosis aims offer novel insights into diagnostic broaden disease treatment.

Language: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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Intestine‐Decipher Engineered Capsules Protect Against Sepsis‐induced Intestinal Injury via Broad‐spectrum Anti‐inflammation and Parthanatos Inhibition

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Sepsis is a severe systemic inflammatory syndrome characterized by dysregulated immune response to infection, often leading high mortality rates. The intestine, owing its distinct structure and physiological environment, plays pivotal role in the pathophysiology of sepsis. It functions as “central organ” or “engine” progression sepsis, with intestinal injury exacerbating condition. Despite availability current therapies that offer partial symptom relief, they fall short adequately protecting barrier. In this study, an advanced nanodrug formulation (OLA@MΦ NPs) developed coating macrophage membranes onto polymeric organic nanoparticles encapsulating olaparib. When loaded into pH‐responsive capsules, intestine‐decipher engineered capsule (cp‐OLA@MΦ successfully formulated. Upon oral administration septic mice, these capsules withstand gastric acid release their contents specifically targeting injured tissues. released OLA@MΦ NPs effectively neutralize pro‐inflammatory cytokines via membrane receptors, while olaparib inhibits epithelial parthanatos (a form programmed cell death) suppressing poly(ADP‐ribose) polymerase 1 (PARP1) activation. This strategy significantly reduces bacterial translocation, slows enhances survival thus presenting promising therapeutic approach for sepsis clinical applications.

Language: Английский

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Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7433 - 7444

Published: Feb. 20, 2025

The immunosuppressive tumor microenvironment in triple-negative breast cancer could hinder the response to thorough immunotherapy and diminish antitumor efficacy. Although STING pathway emerges as a promising target remedy defects, uncertain drug delivery might lead off-target inflammatory reactions. Here, we manifest novel phototheranostic agent with an aggregation-induced emission property that guided pharmacological activation of agonist for photothermal create immunologically "hot" tumor. A pyridinium rotor strategy is proposed develop positively charged TBTP-Bz, which stably coincorporated MSA-2 into thermal-responsive exosome-liposome hybrid nanoparticles tumor-targeting delivery. TBTP-Bz exhibits aggregation-enhanced NIR-II photoacoustic signal, accomplishing real-time tracking. Its stimulation induces immunogenic cell death promotes precise release MSA-2, thus boosting STING-mediated type I interferon production. Significantly, single-dose photoimmunotherapy effectively suppresses abscopal growth provokes immune memory effect inhibit postsurgical recurrent rechallenged tumors. This demonstrates clinical potential poorly cancer.

Language: Английский

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Two Key Descriptors for Designing Second Near-Infrared Dyes and Experimental Validation

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(14), P. 9888 - 9896

Published: March 28, 2024

Second near-infrared (NIR-II) optical imaging technology has emerged as a powerful tool for diagnostic and image-guided surgery due to its higher contrast. However, general strategy efficiently designing NIR-II organic molecules is still lacking, because dyes are usually difficult synthesize, which impeded the rapid development of bioprobes. Herein, based on theoretical calculations 62 multiaryl-pyrrole (MAP) systems with spectra ranging from visible region, continuous red shift toward region could be achieved by adjusting type site substituents MAPs. Two descriptors (ΔEgs μgs) were identified exhibiting strong correlations maximum absorption/emission wavelengths, used predict emission spectrum in only if ΔEgs ≤ 2.5 eV μgs 22.55 D. The experimental absorption ten MAPs fully confirmed predictions, biological vivo newly designed MAP23-BBT showed high spatial resolution deep tissue angiography. More importantly, both have shown applicability most reported donor–acceptor–donor-type non-MAP dyes. These results broad implications efficient design

Language: Английский

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A Review: Surface Engineering of Lipid‐Based Drug Delivery Systems

Small, Journal Year: 2024, Volume and Issue: 20(43)

Published: July 14, 2024

This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.

Language: Английский

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Antibiotic-loaded lactoferrin nanoparticles as a platform for enhanced infection therapy through targeted elimination of intracellular bacteria

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(4), P. 100926 - 100926

Published: May 6, 2024

Intracellular bacteria can multiply inside host cells and manipulate their biology, the efficacy of traditional antibiotic drug therapy for intracellular is limited by inadequate accumulation. Fighting against these stealthy has been a long-standing challenge. Here, system stimuli-responsive lactoferrin (Lf) nanoparticles prepared using protein self-assembly technology to deliver broad-spectrum rifampicin (Rif) (Rif@Lf NPs) enhanced infection through targeted elimination bacteria. Compared Rif@BSA NPs, Rif@Lf NPs specifically target macrophages infected bacteria, thus increasing accumulation Rif within macrophages. Subsequently, with positive surface charge further displayed adherence released rapidly in redox-responsive manner. Combined antibacterial activities Lf Rif, showed abilities biofilms. As result, high safety exhibited excellent therapeutic disease models subcutaneous infection, sepsis, bacterial keratitis. Taken together, antibiotic-loaded present promising platform combat pathogen infections

Language: Английский

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Expanding Our Horizons: AIE Materials in Bacterial Research

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.

Language: Английский

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Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.

Language: Английский

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