Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

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An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(14)

Published: Jan. 2, 2024

One-for-all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due its excellent performance in cancer treatment. Benefitting from the superiority balancing diverse competing energy dissipation pathways, aggregation-induced emission luminogens (AIEgens) are proven be ideal templates for constructing one-for-all multimodal phototheranostic agents. However, this knowledge, all-round AIEgens that can triggered by second near-infrared (NIR-II, 1000-1700 nm) light have not been reported. Given deep tissue penetration high maximum permissible exposure of NIR-II excitation light, herein, work reports first time an laser excitable AIE small molecule (named BETT-2) with features taking full use advantage molecule-facilitated versatility as well synchronously maximizing molecular donor-acceptor strength conformational distortion. As formulated into nanoparticles (NPs), BETT-2 NPs light-driven fluorescence-photoacoustic-photothermal trimodal imaging-guided photodynamic-photothermal synergistic therapy orthotopic mouse breast tumors is fully demonstrated systematic vitro vivo evaluations. This offers valuable insights developing activatable systems.

Language: Английский

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Fused‐Ring Pyrrole‐Based Near‐Infrared Emissive Organic RTP Material for Persistent Afterglow Bioimaging

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(5)

Published: Dec. 12, 2023

Organic near-infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing RTP for deep tissue imaging still faces challenges since the small band gap may increase non-radiative decay, resulting weak emission short lifetime. In this study, fused-ring pyrrole-based structures were employed as guest molecules construction of long wavelength emissive materials. Compared decrease singlet energy level, triplet level showed a more effectively with conjugation substituent groups. Moreover, sufficient fused ring molecule suppresses decay excitons. Therefore, material (764 nm) was achieved penetration bioimaging. Tumor cell membrane is used coat nanoparticles (NPs) avoid decreasing performance compared traditional coating by amphiphilic surfactants. NPs tumor-targeting properties show favorable phosphorescent properties, superior stability, excellent biocompatibility. These are applied time-resolved luminescence eliminate interference penetration. This study provides practical solution prepare long-wavelength long-lifetime organic applications

Language: Английский

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Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Feb. 12, 2024

Abstract The fabrication of a multimodal phototheranostic platform on the basis single‐component theranostic agent to afford both imaging and therapy simultaneously, is attractive yet full challenges. emergence aggregation‐induced emission luminogens (AIEgens), particularly those emit fluorescence in second near‐infrared window (NIR‐II), provides powerful tool for cancer treatment by virtue adjustable pathway radiative/non‐radiative energy consumption, deeper penetration depth aggregation‐enhanced performance. Although bulky thiophene π‐bridges such as ortho ‐alkylated thiophene, 3,4‐ethoxylene dioxythiophene benzo[ c ]thiophene are commonly adopted construct NIR‐II AIEgens, subtle differentiation their behaviours has be comprehensively investigated. In this work, systematical investigations discovered that AIEgen BT‐NS bearing possesses acceptable intensity, efficient reactive oxygen species generation, high photothermal conversion efficiency. Eventually, using nanoparticles, unprecedented performance fluorescence/photoacoustic/photothermal imaging‐guided synergistic photodynamic/photothermal elimination tumors was demonstrated. This study thus offers useful insights into developing versatile systems clinical trials.

Language: Английский

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Near-infrared boron–dipyrrin (BODIPY) nanomaterials: Molecular design and anti-tumor therapeutics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215718 - 215718

Published: Feb. 18, 2024

Language: Английский

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907

Published: May 12, 2024

Language: Английский

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Bioinspired AIE Nanomedicine: A Burgeoning Technology for Fluorescence Bioimaging and Phototheranostics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 14, 2024

Abstract Nanomedicine on the basis of aggregated‐induced emission (AIE) luminogens with exceptional potency is growing into a sparkling frontier in fluorescence imaging and phototheranostics. Of particular interest biomimetic AIE nanomedicine comprised by biocarrier, which represents win–win integration are recently developed at tremendous pace, mainly benefiting from intrinsic advantages including enhanced biocompatibility, prolonged circulation time, specific targeting ability, immune activation, supremely extraordinary phototheranostic outputs. In view inexhaustible vigorous vitality field, this review provides an integrated picture involving basic concepts, significant breakthroughs, recent trends. addition, based current achievements, some critical challenges perspectives also discussed.

Language: Английский

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Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

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NIR‐II Excitable Semiconducting Polymers with AIE Characteristics for Fluorescence‐Photoacoustic Imaging‐Guided Synergistic Phototherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: March 22, 2024

Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar configuration commonly‐used electrophilic acceptor moieties. Herein, an ingenious dimerization‐based distortion strategy proposed current work by taking advantage sterically encumbered acceptors structure for successful construction AIE‐active SPs. Through further finely adjusting molecular donor–acceptor interaction strength, obtained named SP3 bearing highest intramolecular charge transfer effect presented NIR‐II aggregation‐induced fluorescence emission, good reactive oxygen species production ability, superior photothermal conversion performance. Accordingly, selected fabricate nanoparticles successfully applied laser‐triggered fluorescence‐photoacoustic imaging‐guided photodynamic‐photothermal therapy tumors. This study represents first excitable SP, offers a new perspective on designing advanced efficient treatment malignant tumor.

Language: Английский

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