Technology Roadmap for Flexible Sensors

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5211 - 5295

Published: March 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Language: Английский

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Flexible brain–computer interfaces

Nature Electronics, Journal Year: 2023, Volume and Issue: 6(2), P. 109 - 118

Published: Feb. 2, 2023

Language: Английский

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Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 29, 2022

Human brain organoids replicate much of the cellular diversity and developmental anatomy human brain. However, physiology neuronal circuits within remains under-explored. With high-density CMOS microelectrode arrays shank electrodes, we captured spontaneous extracellular activity from derived induced pluripotent stem cells. We inferred functional connectivity spike timing, revealing a large number weak connections skeleton significantly fewer strong connections. A benzodiazepine increased uniformity firing patterns decreased relative fraction weakly connected edges. Our analysis local field potential demonstrate that contain assemblies sufficient size to co-activate generate potentials their collective transmembrane currents phase-lock spiking activity. These results point for study neuropsychiatric diseases, drug action, effects external stimuli upon networks.

Language: Английский

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Shell microelectrode arrays (MEAs) for brain organoids

Science Advances, Journal Year: 2022, Volume and Issue: 8(33)

Published: Aug. 17, 2022

Brain organoids are important models for mimicking some three-dimensional (3D) cytoarchitectural and functional aspects of the brain. Multielectrode arrays (MEAs) that enable recording stimulation activity from electrogenic cells offer notable potential interrogating brain organoids. However, conventional MEAs, initially designed monolayer cultures, limited contact area restricted to bottom 3D Inspired by shape electroencephalography caps, we developed miniaturized wafer-integrated MEA caps The optically transparent shells composed self-folding polymer leaflets with conductive polymer–coated metal electrodes. Tunable folding minicaps’ guided mechanics simulations enables versatile different sizes, validate feasibility electrophysiology 400- 600-μm-sized up 4 weeks in response glutamate stimulation. Our studies suggest shell MEAs great high signal-to-noise ratio spatiotemporal organoid recording.

Language: Английский

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Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids

Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 22, 2024

Language: Английский

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Graphene-integrated mesh electronics with converged multifunctionality for tracking multimodal excitation-contraction dynamics in cardiac microtissues

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 14, 2024

Cardiac microtissues provide a promising platform for disease modeling and developmental studies, which require the close monitoring of multimodal excitation-contraction dynamics. However, no existing assessing tool can track these dynamics across live tissue. We develop tissue-like mesh bioelectronic system to The has tissue-level softness cell-level dimensions enable stable embedment in It is integrated with an array graphene sensors, uniquely converges both bioelectrical biomechanical sensing functionalities one device. achieves tracking tissue throughout process, offering comprehensive assessments maturation, drug effects, modeling. holds promise more accurate quantification functional, developmental, pathophysiological states cardiac tissues, creating instrumental improving engineering studies.

Language: Английский

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Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 14, 2024

Abstract Human hippocampal organoids (hHOs) derived from human induced pluripotent stem cells (hiPSCs) have emerged as promising models for investigating neurodegenerative disorders, such schizophrenia and Alzheimer’s disease. However, obtaining the electrical information of these free-floating in a noninvasive manner remains challenge using commercial multi-electrode arrays (MEAs). The three-dimensional (3D) MEAs developed recently acquired only few neural signals due to limited channel numbers. Here, we report cyborg organoid (cyb-organoid) platform coupling liquid metal-polymer conductor (MPC)-based mesh neuro-interface with hHOs. MPC (mMPC) integrates 128-channel multielectrode distributed on small surface area (~2*2 mm). Stretchability (up 500%) flexibility mMPC enable its attachment Furthermore, show that under Wnt3a SHH activator induction, hHOs produce HOPX + PAX6 progenitors ZBTB20 PROX1 dentate gyrus (DG) granule neurons. transcriptomic signatures reveal high similarity developing hippocampus. We successfully detect activities via this cyb-organoid. Compared traditional planar devices, our non-invasive offers an adaptor recording 3D models.

Language: Английский

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Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering realize biologically-active and/or cell-containing living layers at the tissue-device that enable seamless biointegration novel cell-mediated therapeutic opportunities. This review maps field of electronics discusses key recent developments in tissue-like regenerative bioelectronics, from biomaterials surface-functionalized bioactive coatings 'biohybrid' 'all-living' interfaces. We define contextualize terminology this emerging highlight how biological components can bridge gap clinical translation.

Language: Английский

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Interfacing with the Brain: How Nanotechnology Can Contribute

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Interfacing artificial devices with the human brain is central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along technology. Mechanical levers cable winches were used to move parts during mechanical age. Sophisticated electronic wiring remote control arisen age, ultimately leading plug-and-play computer interfaces. Nonetheless, brains so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, most technology mechanically and/or electrically engineered, whereas a living, dynamic entity. As result, worlds difficult interface one another. Nanotechnology, which encompasses engineered solid-state objects integrated circuits, excels at small length scales single few hundred nanometers and, thus, matches sizes biomolecules, biomolecular assemblies, cells. Consequently, we envision nanomaterials nanotools as opportunities in alternative ways. Here, review existing literature on use nanotechnology look forward discussing perspectives limitations based authors' expertise across range complementary disciplines─from neuroscience, engineering, physics, chemistry biology medicine, science mathematics, social jurisprudence. We focus but also include information from related fields when useful complementary.

Language: Английский

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Pushing the boundaries of brain organoids to study Alzheimer’s disease

Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(8), P. 659 - 672

Published: June 22, 2023

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function multiple brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining how complex cell-cell interactions become dysregulated in AD requires novel human cell-based vitro platforms that could recapitulate the intricate cytoarchitecture diversity brain. Brain organoids (BOs) are 3D self-organizing tissues partially resemble architecture can AD-relevant pathology. In this review, we highlight versatile applications different types BOs model pathogenesis, including amyloid-β tau aggregation, neuroinflammation, myelin breakdown, vascular dysfunction, other phenotypes, as well accelerate therapeutic development for AD.

Language: Английский

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