A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca²⁺‐Overload‐Enhanced Catalytic Tumor Nanotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(43)

Published: Sept. 15, 2022

The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation reactive oxygen species (ROS) caused by valence change metal elements. However, very little research focused on and has achieved exploration development enzyme-mimicking activities valence-invariable compounds. Herein, a distinct calcium fluoride (CaF2 ) nanozyme ultrasound (US)-enhanced peroxidase (POD)-mimicking activity rationally designed engineered efficient (Ca2+ )-overload-enhanced catalytic tumor nanotherapy, which first paradigm Ca-based cancer treatment. release exogenous Ca2+ ions from CaF2 nanocrystals deleterious ROS derived US-amplified POD-mimicking properties facilitate intracellular accumulation achieve -overload-induced mitochondrial dysfunction through introducing regulating calcium-pumping channels neoplastic cells. Especially, US as an energy input capable substantially amplifying nanozyme, ultimately achieving anti-neoplastic outcome both 4T1 breast H22 hepatic carcinoma animal models. Such discovery enzyme-like compounds can broaden cognition scope effectively serves field chemoreactive nanomedicine.

Language: Английский

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Nanozyme-mediated biocatalysis as a mitochondrial oxidative stress amplifier for tumor nanocatalytic immunotherapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 481, P. 148270 - 148270

Published: Dec. 23, 2023

Language: Английский

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Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies

Biomaterials Research, Journal Year: 2022, Volume and Issue: 26(1)

Published: July 6, 2022

Theranostic nanoplatforms integrating diagnostic and therapeutic functions have received considerable attention in the past decade. Among them, hollow manganese (Mn)-based are superior since they combine advantages of structures intrinsic theranostic features Mn

Language: Английский

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Fe(III)‐Naphthazarin Metal–Phenolic Networks for Glutathione‐Depleting Enhanced Ferroptosis–Apoptosis Combined Cancer Therapy

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 11, 2023

Abstract Nowadays, Fenton chemistry‐based chemodynamic therapy (CDT) is an emerging approach to killing tumor cells by converting endogenous H 2 O into cytotoxic hydroxyl radicals (·OH). However, the elimination of ·OH intracellular overexpressed glutathione (GSH) results in unsatisfactory antitumor efficiency. In addition, single mode consuming GSH and undesirable drug loading efficiency cannot guarantee efficient cancer effect. Herein, a simple one‐step strategy for construction Fe 3+ ‐naphthazarin metal–phenolic networks (FNP MPNs) with ultrahigh capacity, followed modification NH ‐PEG‐NH , developed. The carrier‐free FNP MPNs can be triggered acid GSH, rapidly release naphthazarin which further reduced 2+ that exerts catalytic activity produce abundant ·OH. Meanwhile, Michael addition between lead depletion thus achieve microenvironment (TME)‐triggered enhanced CDT, activating ferroptosis apoptosis. as T 1 ‐weighted contrast agent endows magnetic resonance imaging (MRI) functionality. Overall, this work debut ligands fabricate functional effectively depleting disrupting redox homeostasis, enhancing CDT effects, opens new perspectives on multifunctional synergistic therapy.

Language: Английский

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Boosting Ferroptosis Therapy with Iridium Single‐Atom Nanocatalyst in Ultralow Metal Content

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Jan. 31, 2023

Nanocatalysts are promising tumor therapeutics due to their ability induce reactive oxygen species in the microenvironment. Although increasing metal loading can improve catalytic activity, quandary of high content versus potential systemic biotoxicity remains challenging. Here, a fully exposed active site strategy by site-specific anchoring single iridium (Ir) atoms on outer surface nitrogen-doped carbon composite (Ir single-atom catalyst (SAC)) is reported achieve remarkable performance at ultralow (≈0.11%). The Ir SAC exhibits prominent dual enzymatic activities mimic peroxidase and glutathione peroxidase, which catalyzes conversion endogenous H2 O2 into •OH acidic TME depletes (GSH) simultaneously. With an advanced support GSH-trapping platinum(IV) encapsulation with red-blood-cell membrane, this nanocatalytic agent (Pt@IrSAC/RBC) causes intense lipid peroxidation that boosts cell ferroptosis. Pt@IrSAC/RBC demonstrates superior therapeutic efficacy mouse triple-negative mammary carcinoma model, resulting complete ablation treatment session negligible side effects. These outcomes may provide valuable insights design nanocatalysts biosafety for biomedical applications.

Language: Английский

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Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 16, 2023

Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.

Language: Английский

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A Metal‐Free Mesoporous Carbon Dots/Silica Hybrid Type I Photosensitizer with Enzyme‐Activity for Synergistic Treatment of Hypoxic Tumor

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: March 10, 2023

Abstract As a less O 2 ‐dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia‐induced low efficiency against solid tumors. However, commonly used metal‐involved agents suffer from long‐term biosafety concern. Herein, metal‐free photosensitizer, N ‐doped carbon dots/mesoporous silica nanoparticles (NCDs/MSN, ≈40 nm) nanohybrid with peroxidase (POD)‐like activity for synergistic and enzyme‐activity treatment, developed on gram scale via facile one‐pot strategy through mixing source precursor assistance of template. Benefiting narrow bandgap (1.92 eV) good charge separation capacity NCDs/MSN, upon 640 nm light irradiation, excited electrons in conduction band can effectively generate •− by reduction dissolved one‐electron transfer process even under hypoxic conditions, inducing apoptosis tumor cells. Moreover, photoinduced partially transform into more toxic • OH two‐electron reduction. POD‐like NCDs/MSN catalyze endogenous H microenvironment, further synergistically ablating 4T1 Therefore, mass production way synthesize novel photosensitizer enzyme‐mimic treatment tumors provided, which exhibits promising clinical translation prospects.

Language: Английский

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Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 22, 2024

Abstract Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis amplify efficacy sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine copper, ultrasound-activated piezo-hot carriers transfer easily copper polydopamine. It boosts reactive oxygen species production piezoelectrics, facilitates interconversion between Cu2 + Cu promote hydroxyl radical generation via -catalyzed reactions. Finally, elevated cause membrane structure loosening DNA damage. Transcriptomics metabolomics analysis reveal that intracellular overload restricts tricarboxylic acid cycle, promoting cuproptosis-like death. Therefore, polyetherketoneketone scaffold engineered designed shows excellent antibacterial performance ultrasound stimulation promotes angiogenesis osteogenesis on-demand vivo.

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Self‐Assembled Copper‐Based Nanoparticles for Glutathione Activated and Enzymatic Cascade‐Enhanced Ferroptosis and Immunotherapy in Cancer Treatment

Small, Journal Year: 2023, Volume and Issue: 19(35)

Published: April 28, 2023

As an emerging cancer treatment strategy, ferroptosis is greatly restricted by excessive glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) generation efficiency. Here, this work designs self-assembled copper-alanine nanoparticles (CACG) loaded with glucose oxidase (GOx) cinnamaldehyde (Cin) for situ activated enzymatic cascade-enhanced immunotherapy. In response to GSH-rich acidic TME, CACG allows effectively co-deliver Cu2+ , Cin, GOx into tumors. Released Cin consumes GSH through Michael addition, accompanying the reduction of Cu+ further depletion. With cascade -catalyzed Fenton reactions enzyme-catalyzed GOx, could get rid restriction insufficient hydrogen peroxide leading a robust constant ROS. high efficiency depletion ROS production, significantly enhanced vivo. Moreover, elevated oxidative stress triggers immune responses promoting dendritic cells maturation T cell infiltration. The vivo results prove that efficiently inhibit growth 4T1 tumor-bearing mouse model without causing obvious systemic toxicity, suggesting great potential enhancing immunotherapy effective treatment.

Language: Английский

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