Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Oct. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Language: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6746 - 6761

Published: Jan. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Language: Английский

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Heterointerface and crystallinity engineering of Ru/RuS2 dual co-catalysts for enhanced photocatalytic hydrogen evolution

Applied Catalysis B Environment and Energy, Journal Year: 2024, Volume and Issue: unknown, P. 123722 - 123722

Published: Jan. 1, 2024

Language: Английский

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Development of organic photosensitizers for antimicrobial photodynamic therapy

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(15), P. 5108 - 5128

Published: Jan. 1, 2023

This review mainly summarises the recent progress in development of organic photosensitizers, including porphyrins, chlorophyll, phenothiazines, xanthenes and aggregation-induced emission for antimicrobial photodynamic therapy.

Language: Английский

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Metal−Organic Frameworks Nucleated by Silk Fibroin and Modified with Tumor‐Targeting Peptides for Targeted Multimodal Cancer Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 23, 2023

Abstract Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific locations in a controlled manner. Here, the study presents novel nanoplatform constructed using zeolitic imidazolate framework‐8 ( Z IF‐8), nanoscale metal‐organic framework nucleated under mediation of silk fibroin S F). The is modified with newly discovered MCF‐7 breast tumor‐targeting peptide, AREYGTRFSLIGGYR AR peptide). Indocyanine green I CG) and doxorubicin D OX) are loaded onto high encapsulation efficiency (>95%). ICG enables resultant nanoparticles (NPs), called AR‐ZS/ID‐P, release reactive oxygen species for photodynamic P DT) heat photothermal TT) near‐infrared (NIR) irradiation, promoting NIR fluorescence thermal imaging guide DOX‐induced chemotherapy. Additionally, both DOX at acidic tumor conditions due dissolution ZIF‐8 provides drug‐targeting mechanism addition peptide. When intravenously injected, AR‐ZS/ID‐P NPs specifically target tumors exhibit higher anticancer efficacy than other groups through ICG‐enabled PDT PTT DOX‐derived chemotherapy, without inducing side effects. results demonstrate promising multimodal theranostic maximal therapeutic minimal effects targeted controllable delivery.

Language: Английский

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Underwater Self-Healing and Recyclable Ionogel Sensor for Physiological Signal Monitoring

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(23), P. 28664 - 28674

Published: June 5, 2023

Ionogels with self-healing properties have become more and desirable because they can improve the reliability, safety, fatigue-resistant performance of flexible devices. However, property ionogels is usually susceptible to water molecules, application ionogel sensors limited atmospheric environment. Inspired by gelatinous jellyfish, herein, an underwater was prepared via one-step photoinitiated polymerization acrylic acid 2,2,2-trifluoroethyl ester N-isopropylacrylamide (NIPAm) in a hydrophobic ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIm][TFSI]). The dynamic physical interactions (hydrogen bonding ion-dipole interactions) endowed remarkable transparency, (up 96%), toughness (3.93 MJ m-3), adhesion. And cross-linking could be green recycled ethanol for further application. Especially, ionogel-based sensor presented excellent strain pressure sensing sensitivity, rapid responsiveness (140 ms), ultrastability. assembled into optical camouflage detect distinguish different human motions real time high stability, repeatability, as well electrocardiography monitoring wirelessly. This provides promising strategy development sensors.

Language: Английский

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Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20875 - 20924

Published: Oct. 23, 2023

Cancer with a complex pathological process is major disease to human welfare. Due the imbalance between oxygen (O2) supply and consumption, hypoxia natural characteristic of most solid tumors an important obstacle for cancer therapy, which closely related tumor proliferation, metastasis, invasion. Various strategies exploit feature have been developed in past decade, can be used alleviate hypoxia, or utilize targeted delivery diagnostic imaging. The include delivering O2, situ O2 generation, reprogramming vascular system, decreasing inhibiting HIF-1 pathways. On other side, also utilized hypoxia-responsive chemical construction hypoxia-active prodrug-based strategies. Taking advantage region, number methods applied identify keep track changes hypoxia. Herein, we thoroughly review recent progress nanomedicine both conquering utilizing combat put forward prospect emerging nanomaterials future clinical transformation, hopes provide perspectives design.

Language: Английский

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Advances in near-infrared-activated lanthanide-doped optical nanomaterials: imaging, sensing, and therapy

Materials & Design, Journal Year: 2023, Volume and Issue: 231, P. 112036 - 112036

Published: May 25, 2023

As the population ages, cancer has become a major health concern. Although surgical treatment, chemoradiotherapy, and other clinical treatments have dominant, their strong invasiveness intolerable toxic side effects seriously affect patients' quality of life. Therefore, developing non-invasive optical therapy with high safety is great significance. In last two decades development, progress been made in lanthanide doped nanoparticles on biomedical applications under near-infrared (NIR) light due to unique properties. These nanomaterials used wide range applications, including bioluminescence marker detection, vitro vivo imaging, photodynamic (PDT), photothermal (PTT), therapeutic applications. therapies rapidly developed profession involving oncology non-invasive, spatiotemporal controllability, efficiency. For this key review, based listed as follows: bioimaging, biosensors, PDT PTT. Some emerging biological lanthanide-doped currently at forefront nano/biological interface are also discussed. Finally, review summarizes future opportunities challenges nanotechnology research nanoparticles.

Language: Английский

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Nitric Oxide‐Assisted Photodynamic Therapy for Enhanced Penetration and Hypoxic Bacterial Biofilm Elimination

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(29)

Published: July 29, 2023

The presence of a biofilm matrix barrier and hypoxic microenvironment within the significantly impedes efficacy photodynamic therapy for bacterial infections. Herein, phototherapeutic nanoagent with type-I behavior nitric oxide (NO) release performance is reported overcoming biofilm-associated infectious diseases. Sodium nitroprusside (SNP), NO donor, loaded onto amino-modified mesoporous silica nanoparticles (MSN) to form MSN@SNP NPs. resulting are further modified porphyrin-based metal-organic framework (Ti-TCPP MOF) obtain MSN@MOF/SNP NPs (MMS NPs) applications. In hypoxia microenvironment, MMS enhance permeability induce generation hydroxyl radical (•OH) superoxide anion (O2•- ) via Type-I pathway under laser irradiation. Subsequently, infections effectively eliminated through reactive oxygen species (ROS) gas synergistic therapy. addition, also stimulates collagen deposition promotes angiogenesis in vivo. Therefore, efficiently treat biofilm-related infections, providing an alternative approach combat

Language: Английский

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Antioxidative single atomic nanocatalysts facilitate orally administered probiotic inulin gels for acute colitis amelioration

Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102150 - 102150

Published: Jan. 12, 2024

Language: Английский

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