Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(42)
Published: June 21, 2022
Abstract
Immunotherapy
is
one
of
the
most
promising
clinical
modalities
for
treatment
malignant
tumors
and
has
shown
excellent
therapeutic
outcomes
in
settings.
However,
it
continues
to
face
several
challenges,
including
long
cycles,
high
costs,
immune‐related
adverse
events,
low
response
rates.
Thus,
critical
predict
rate
immunotherapy
by
using
imaging
technology
preoperative
intraoperative.
Here,
latest
advances
nanosystem‐based
biomaterials
used
predicting
responses
via
immune
cells
signaling
molecules
microenvironment
are
comprehensively
summarized.
Several
methods,
such
as
fluorescence
imaging,
magnetic
resonance
positron
emission
tomography
ultrasound
photoacoustic
predictive
discussed
show
potential
nanosystems
distinguishing
responders
from
nonresponders.
Nanosystem‐based
aided
various
technologies
expected
enable
effective
prediction
diagnosis
cases
tumors,
inflammation,
other
public
diseases.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(2)
Published: Nov. 24, 2022
Diabetic
foot
ulcers
(DFU),
one
of
the
most
serious
complications
diabetes,
are
essentially
chronic,
nonhealing
wounds
caused
by
diabetic
neuropathy,
vascular
disease,
and
bacterial
infection.
Given
its
pathogenesis,
DFU
microenvironment
is
rather
complicated
characterized
hyperglycemia,
ischemia,
hypoxia,
hyperinflammation,
persistent
However,
current
clinical
therapies
for
dissatisfactory,
which
drives
researchers
to
turn
attention
advanced
nanotechnology
address
therapeutic
bottlenecks.
In
last
decade,
a
large
number
multifunctional
nanosystems
based
on
have
been
developed
with
positive
effects
in
therapy,
forming
novel
concept
"DFU
nanomedicine".
systematic
overview
nanomedicine
still
unavailable
literature.
This
review
summarizes
microenvironmental
characteristics
DFU,
presents
main
progress
wound
healing,
summaries
state-of-the-art
strategies
DFU.
Furthermore,
challenges
future
perspectives
this
field
discussed
prospected,
aiming
fuel
foster
development
nanomedicines
successfully.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(25)
Published: April 13, 2023
Diabetic
wounds
are
characterized
by
drug-resistant
bacterial
infections,
biofilm
formation,
impaired
angiogenesis
and
perfusion,
oxidative
damage
to
the
microenvironment.
Given
their
complex
nature,
diabetic
remain
a
major
challenge
in
clinical
practice.
Reactive
oxygen
species
(ROS),
which
have
been
shown
trigger
hyperinflammation
excessive
cellular
apoptosis,
play
pivotal
role
pathogenesis
of
wounds.
ROS-scavenging
nanosystems
recently
emerged
as
smart
multifunctional
nanomedicines
with
broad
synergistic
applicability.
The
documented
anti-inflammatory
pro-angiogenic
ability
treatments
predestines
these
promising
options
for
treatment
Yet,
this
context,
therapeutic
applicability
efficacy
be
elucidated.
Herein,
ROS
is
deciphered,
properties
strengths
capacity
summarized.
In
addition,
current
challenges
such
potential
future
directions
discussed
through
clinical-translational
lens.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(23)
Published: March 8, 2023
Abstract
Antimicrobial
peptides
(AMPs)
with
dual
intrinsic
antibacterial
and
antioxidative
functions
have
emerged
as
promising
choice
to
cure
infected
wound.
However,
the
most
widely
applied
approach
endow
AMPs
function
is
combine
moieties,
which
may
affect
spatial
structure
physiological
stability
of
AMPs.
Herein,
a
new
type
inherent
desired
stability,
activity,
reactive
oxygen
species
(ROS)
scavenging
developed
effectively
heal
This
formulation
in
situ
formed
at
wound
site
by
tyrosinase‐triggered
oxidation
self‐assembly
lyophilized
antimicrobial
peptide
Trp‐Arg‐Trp‐Arg‐Trp‐Tyr,
providing
enhanced
fourfold
sevenfold
increasement
efficiency
against
E.
coli
S.
aureus
compared
monomers.
The
first
oxidized
then
assembled
into
nanoparticles.
melanin‐like
has
been
demonstrated
efficient
antioxidant
properties,
experimental
data
show
that
nanoparticles
scavenge
superoxide
radicals,
hydroxyl
H
2
O
.
In
vivo
experiments
confirmed
wounds
obviously
reduce
ROS.
Overall,
research
provides
formulating
treat
high
healing
efficiency.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(26)
Published: Feb. 26, 2024
Abstract
Chronic
inflammation
and
excessive
reactive
oxygen
species
(ROS)
can
impair
diabetic
wound
healing.
Regulatory
T
cells
(Tregs)
have
emerged
as
a
promising
target
to
promote
healing
by
regulating
the
immune
system
supporting
tissue
repair
through
secretion
of
growth
factors
cytokines.
However,
an
effective
strategy
for
on‐demand
recruitment
Tregs
is
still
lacking.
Here,
ROS‐scavenging
Tregs‐recruiting
hydrogel
patch
developed
sequential
release
C─C
motif
chemokine
22
(CCL22)
triggered
ROS
in
bed.
The
prepared
crosslinking
gelatin
with
cleavable
linker
together
CCL22
(RSG‐CCL22).
RSG‐CCL22
presented
desirable
physical
properties
suitable
skin
regeneration
purposes.
In
addition,
scavenging
feature
RSG
suppresses
differentiation
helper
17
(Th17)
protects
recruited
from
apoptosis
oxidative
stress,
which
maximizes
their
function
accelerating
closure
promoting
hair
follicle
full‐thickness
defect
mouse
model.
Therefore,
proposed
approach
provides
new
therapeutic
via
functional
ROS‐triggered
delivery.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 6, 2024
Abstract
Background
The
prognosis
for
hepatocellular
carcinoma
(HCC)
remains
suboptimal,
characterized
by
high
recurrence
and
metastasis
rates.
Although
metalloimmunotherapy
has
shown
potential
in
combating
tumor
proliferation,
metastasis,
current
apoptosis-based
fails
to
elicit
sufficient
immune
response
HCC.
Results
A
smart
responsive
bimetallic
nanovaccine
was
constructed
induce
immunogenic
cell
death
(ICD)
through
pyroptosis
enhance
the
efficacy
of
cGAS-STING
pathway.
composed
manganese-doped
mesoporous
silica
as
a
carrier,
loaded
with
sorafenib
(SOR)
modified
MIL-100
(Fe),
where
Fe
3+
,
SOR,
Mn
2+
were
synchronized
released
into
help
microenvironment
(TME).
Afterward,
worked
synergistically
SOR-induced
(via
both
classical
nonclassical
signaling
pathways),
causing
outflow
abundant
factors,
which
contributes
dendritic
(DC)
maturation,
exposure
double-stranded
DNA
(dsDNA).
Subsequently,
exposed
dsDNA
jointly
activated
pathway
induced
release
type
I
interferons,
further
led
DC
maturation.
Moreover,
-related
T1
magnetic
resonance
imaging
(MRI)
used
visually
evaluate
functionality
nanovaccine.
Conclusion
utilization
metallic
nanovaccines
pyroptosis-mediated
activation
provides
promising
paradigm
HCC
treatment.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 51 - 71
Published: March 15, 2024
Intervertebral
disc
degeneration
(IVDD)
can
be
caused
by
aging,
injury,
and
genetic
factors.
The
pathological
changes
associated
with
IVDD
include
the
excessive
accumulation
of
reactive
oxygen
species
(ROS),
cellular
pyroptosis,
extracellular
matrix
(ECM)
degradation.
There
are
currently
no
approved
specific
molecular
therapies
for
IVDD.
In
this
study,
we
developed
a
multifunctional
microenvironment-responsive
metal-phenolic
network
release
platform,
termed
TMP@Alg-PBA/PVA,
which
could
treat
(IL-1β)-induced
(TA-Mn-PVP,
TMP)
released
from
platform
targeted
mitochondria
to
efficiently
scavenge
ROS
reduce
ECM
Pyroptosis
was
suppressed
through
inhibition
IL-17/ERK
signaling
pathway.
These
findings
demonstrate
versatility
platform.
And
in
rat
model
IVDD,
TMP@Alg-PBA/PVA
exhibited
excellent
therapeutic
effects
reducing
progression
disease.
therefore,
presents
clinical
potential
treatment
