Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122841 - 122841
Published: Sept. 14, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: April 23, 2024
Abstract Wound healing is an obvious clinical concern that can be hindered by inadequate angiogenesis, inflammation, and chronic hypoxia. While exosomes derived from adipose tissue-derived stem cells have shown promise in accelerating carrying therapeutic growth factors microRNAs, intracellular cargo delivery compromised hypoxic tissues due to activated hypoxia-induced endocytic recycling. To address this challenge, we developed a strategy coat oxygen nanobubbles with incorporate them into polyvinyl alcohol/gelatin hybrid hydrogel. This approach not only alleviates wound hypoxia but also offers efficient means of delivering exosome-coated nanoparticles conditions. The self-healing properties the hydrogel, along its component, gelatin, aids hemostasis, while crosslinking bonds facilitate hydrogen peroxide decomposition, ameliorate inflammation. Here, show potential multifunctional hydrogel for enhanced healing, promoting facilitating exosome delivery, mitigating hypoxia, inhibiting inflammation male rat full-thickness model.
Language: Английский
Citations
67
Exploration, Journal Year: 2024, Volume and Issue: 4(3)
Published: Jan. 17, 2024
Abstract Reactive oxygen species play a crucial role in cell signaling pathways during wound healing phases. Treatment strategies to balance the redox level deep tissue are emerging for management. In recent years, reactive scavenging agents including natural antioxidants, (ROS) nanozymes, and antioxidant delivery systems have been widely employed inhibit oxidative stress promote skin regeneration. Here, importance of different phases is critically analyzed. Various cutting‐edge bioactive ROS nanoscavengers platforms discussed. This review also highlights future directions therapies via scavenging. comprehensive offers map research on scavengers with balancing mechanisms action process, which benefits development clinical applications next‐generation scavenging‐based nanomaterials
Language: Английский
Citations
59
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)
Published: June 21, 2023
Abstract Engineered skin substitutes derived from human significantly reduce inflammatory reactions mediated by foreign/artificial materials and are consequently easier to use for clinical application. Type I collagen is a main component of the extracellular matrix during wound healing has excellent biocompatibility, platelet‐rich plasma can be used as initiator cascade. Adipose mesenchymal stem cell exosomes crucial tissue repair play key roles in enhancing regeneration, promoting angiogenesis, regulating inflammation, remodeling matrix. Herein, plasma, which provide natural supports keratinocyte fibroblast adhesion, migration, proliferation, mixed form stable 3D scaffold. added scaffold improve performance engineered skin. The physicochemical properties this cellular analyzed, effect evaluated full‐thickness defect mouse model. reduces level inflammation promotes proliferation angiogenesis accelerate healing. Proteomic analysis shows that exhibit anti‐inflammatory proangiogenic effects collagen/platelet‐rich scaffolds. proposed method provides new therapeutic strategy theoretical basis regeneration repair.
Language: Английский
Citations
58
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 14, 2023
Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role fibroblasts is multifaceted, ranging from activation recruitment innate immune cells through synthesis deposition scar tissue conveyor belt-like transport fascial connective into wounds. A comprehensive understanding fibroblast diversity versatility in machinery may help decipher pathologies whilst laying foundation for novel treatment modalities. In this review, we portray delineate their unique functions. addition, discuss future directions clinical-translational lens.
Language: Английский
Citations
44
ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17251 - 17266
Published: June 22, 2024
Designing adaptive and smart hydrogel wound dressings to meet specific needs across different stages of healing is crucial. Here, we present a composite hydrogel, GSC/PBE@Lut, that offers self-regulating release cupric ions luteolin modulates mechanical properties promote chronic healing. The double network GSC, fabricated through photo-cross-linking gelatin methacrylate, followed by Cu2+-alginate coordination cross-linking. On one hand, GSC allows for rapid Cu2+ eliminate bacteria in the acidic pH environment during inflammation reduces hydrogel's strength minimize tissue trauma early dressing changes. other enables slow proliferation stage, promoting angiogenesis biocompatibility. Furthermore, inclusion pH- reactive oxygen species (ROS)-responsive nanoparticles (PBE@Lut) matrix controlled luteolin, offering antioxidant anti-inflammatory effects macrophage polarization. In murine model Staphylococcus aureus infected wounds, GSC/PBE@Lut demonstrates exceptional therapeutic benefits antibacterial, anti-inflammatory, angiogenic, regeneration. Overall, our results suggest hydrogels with bioactive agent modulation promising solution treating wounds.
Language: Английский
Citations
36
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130741 - 130741
Published: March 7, 2024
Language: Английский
Citations
27
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148768 - 148768
Published: Jan. 18, 2024
Language: Английский
Citations
26
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)
Published: May 12, 2024
Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding
Language: Английский
Citations
25
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(2), P. 2140 - 2153
Published: Jan. 5, 2024
Multivalent ion cross-linking has been used to form hydrogels between sodium alginate (SA) and hyaluronic acid (HA) in previous studies. However, more stable robust covalent is rarely reported. Herein, we present a facile approach fabricate SA HA hydrogel for wound dressings with injectable, good biocompatibility, high ductility. was first reacted ethylenediamine graft an amino group. Then, it cross-linked oxidized dialdehyde networks. The dressing can effectively promote cell migration healing. To increase the antibacterial property of dressing, successfully loaded tetracycline hydrochloride into as model drug. drug be released slowly alkaline environment chronic wounds, releases drugs again acidic healing, achieving long-term effect. In addition, one-dimensional partial differential equations based on Fickian diffusion time-varying coefficients thicknesses were entire complex release process predict release.
Language: Английский
Citations
23
Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 67 - 81
Published: Jan. 23, 2024
Hypoxia, excessive reactive oxygen species (ROS), and impaired angiogenesis are prominent obstacles to wound healing following trauma surgical procedures, often leading the development of keloids hypertrophic scars. To address these challenges, a novel approach has been proposed, involving cascade enzymatic reaction-based nanocarriers-laden dressing. This advanced technology incorporates superoxide dismutase modified nanobubbles catalase within an alginate hydrogel matrix. The nano chamber functions through reaction between catalase, wherein in environment is enzymatically decomposed into hydrogen peroxide, this peroxide subsequently converted by catalase. effectively controls inflammation hypoxia, mitigating risk keloid formation. Concurrently, release continuously, thus providing sustained supply site. from dynamic system stimulates fibroblast proliferation, fosters formation new blood vessels, contributes overall process. In rat full-thickness model, displayed notable capacity expedite without scarring. Furthermore, pilot study porcine healing, acceleration tissue repair was observed conceived gel treated group 3 days post-surgery, which represents proliferation stage These achievements hold significant importance ensuring complete functional recovery tissues, thereby highlighting its potential as promising for enhancing outcomes.
Language: Английский
Citations
17