One‐Step Synthesis of Hydrogel Adhesive with Acid‐Responsive Tannin Release for Diabetic Oral Mucosa Defects Healing DOI

Kaize Su,

Jinxuan Li,

Xiaoxian Wu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(9)

Published: Jan. 21, 2024

Abstract The complex preparation, weak wet tissue adhesion, and limited biological activity of traditional oral wound dressings usually impede their efficient treatment healing for diabetic mucosal defects. To overcome these problems, a novel hydrogel adhesive (named CFT hydrogel) is rapidly constructed using one‐step method based on dual‐dynamic covalent cross‐linking. Compared with the commercial patches, shows superior in vivo (rat tongue) adhesion performance. Additionally, exhibits unique acid‐responsive properties, thereby facilitating release bioactive molecule tannic acid acidic microenvironment. And series vitro experiments substantiate favorable biocompatibility bioactivity properties (including antibacterial, antioxidative, anti‐inflammatory, angiogenetic effects) exhibited by hydrogel. Moreover, conducted rat model defects demonstrate that significant efficacy protecting against wounds, alleviating inflammatory reactions, wound‐healing process. Taken together, this study provides promising comprehensive therapeutic option great potential clinical management mucosa patients.

Language: Английский

Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing DOI Creative Commons
Xiaoxue Han, Chaimongkol Saengow,

Leah Ju

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 23, 2024

Abstract Wound healing is an obvious clinical concern that can be hindered by inadequate angiogenesis, inflammation, and chronic hypoxia. While exosomes derived from adipose tissue-derived stem cells have shown promise in accelerating carrying therapeutic growth factors microRNAs, intracellular cargo delivery compromised hypoxic tissues due to activated hypoxia-induced endocytic recycling. To address this challenge, we developed a strategy coat oxygen nanobubbles with incorporate them into polyvinyl alcohol/gelatin hybrid hydrogel. This approach not only alleviates wound hypoxia but also offers efficient means of delivering exosome-coated nanoparticles conditions. The self-healing properties the hydrogel, along its component, gelatin, aids hemostasis, while crosslinking bonds facilitate hydrogen peroxide decomposition, ameliorate inflammation. Here, show potential multifunctional hydrogel for enhanced healing, promoting facilitating exosome delivery, mitigating hypoxia, inhibiting inflammation male rat full-thickness model.

Language: Английский

Citations

86
Recent advances in reactive oxygen species scavenging nanomaterials for wound healing DOI Creative Commons

Alireza Joorabloo,

Tianqing Liu

Exploration, Journal Year: 2024, Volume and Issue: 4(3)

Published: Jan. 17, 2024

Abstract Reactive oxygen species play a crucial role in cell signaling pathways during wound healing phases. Treatment strategies to balance the redox level deep tissue are emerging for management. In recent years, reactive scavenging agents including natural antioxidants, (ROS) nanozymes, and antioxidant delivery systems have been widely employed inhibit oxidative stress promote skin regeneration. Here, importance of different phases is critically analyzed. Various cutting‐edge bioactive ROS nanoscavengers platforms discussed. This review also highlights future directions therapies via scavenging. comprehensive offers map research on scavengers with balancing mechanisms action process, which benefits development clinical applications next‐generation scavenging‐based nanomaterials

Language: Английский

Citations

76
Adipose Mesenchymal Stem Cell Derived Exosomes Promote Keratinocytes and Fibroblasts Embedded in Collagen/Platelet‐Rich Plasma Scaffold and Accelerate Wound Healing DOI Creative Commons
Yunchuan Wang, Yue Zhang, Ting Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)

Published: June 21, 2023

Abstract Engineered skin substitutes derived from human significantly reduce inflammatory reactions mediated by foreign/artificial materials and are consequently easier to use for clinical application. Type I collagen is a main component of the extracellular matrix during wound healing has excellent biocompatibility, platelet‐rich plasma can be used as initiator cascade. Adipose mesenchymal stem cell exosomes crucial tissue repair play key roles in enhancing regeneration, promoting angiogenesis, regulating inflammation, remodeling matrix. Herein, plasma, which provide natural supports keratinocyte fibroblast adhesion, migration, proliferation, mixed form stable 3D scaffold. added scaffold improve performance engineered skin. The physicochemical properties this cellular analyzed, effect evaluated full‐thickness defect mouse model. reduces level inflammation promotes proliferation angiogenesis accelerate healing. Proteomic analysis shows that exhibit anti‐inflammatory proangiogenic effects collagen/platelet‐rich scaffolds. proposed method provides new therapeutic strategy theoretical basis regeneration repair.

Language: Английский

Citations

63
A Double Network Composite Hydrogel with Self-Regulating Cu2+/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing DOI
Yue Li, Yunpeng Wang, Yuanyuan Ding

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17251 - 17266

Published: June 22, 2024

Designing adaptive and smart hydrogel wound dressings to meet specific needs across different stages of healing is crucial. Here, we present a composite hydrogel, GSC/PBE@Lut, that offers self-regulating release cupric ions luteolin modulates mechanical properties promote chronic healing. The double network GSC, fabricated through photo-cross-linking gelatin methacrylate, followed by Cu2+-alginate coordination cross-linking. On one hand, GSC allows for rapid Cu2+ eliminate bacteria in the acidic pH environment during inflammation reduces hydrogel's strength minimize tissue trauma early dressing changes. other enables slow proliferation stage, promoting angiogenesis biocompatibility. Furthermore, inclusion pH- reactive oxygen species (ROS)-responsive nanoparticles (PBE@Lut) matrix controlled luteolin, offering antioxidant anti-inflammatory effects macrophage polarization. In murine model Staphylococcus aureus infected wounds, GSC/PBE@Lut demonstrates exceptional therapeutic benefits antibacterial, anti-inflammatory, angiogenic, regeneration. Overall, our results suggest hydrogels with bioactive agent modulation promising solution treating wounds.

Language: Английский

Citations

50
Fibroblasts – the cellular choreographers of wound healing DOI Creative Commons
Samuel Knoedler,

Sonja Broichhausen,

Ruiji Guo

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 14, 2023

Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role fibroblasts is multifaceted, ranging from activation recruitment innate immune cells through synthesis deposition scar tissue conveyor belt-like transport fascial connective into wounds. A comprehensive understanding fibroblast diversity versatility in machinery may help decipher pathologies whilst laying foundation for novel treatment modalities. In this review, we portray delineate their unique functions. addition, discuss future directions clinical-translational lens.

Language: Английский

Citations

49
The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing DOI
Zhuoya Wang, Danyang Chen, Hongying Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 12, 2024

Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding

Language: Английский

Citations

32
Antioxidative bioactive glass reinforced injectable hydrogel with reactive oxygen species scavenging capacity for diabetic wounds treatment DOI
Hao Chang,

Pengfei Tian,

Liuzhi Hao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148768 - 148768

Published: Jan. 18, 2024

Language: Английский

Citations

30
A pH responsive tannic acid/quaternized carboxymethyl chitosan/oxidized sodium alginate hydrogels for accelerated diabetic wound healing and real-time monitoring DOI

Zhifei Yang,

Chen Wang, Zhiyuan Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130741 - 130741

Published: March 7, 2024

Language: Английский

Citations

28
Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing DOI Creative Commons

Yuheng Liao,

Zhenhe Zhang,

Yanzhi Zhao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151

Published: Oct. 15, 2024

Language: Английский

Citations

28
Mg-gallate metal-organic framework-based sprayable hydrogel for continuously regulating oxidative stress microenvironment and promoting neurovascular network reconstruction in diabetic wounds DOI Creative Commons

Chenxi Lian,

Jiawei Liu, Wenying Wei

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 181 - 194

Published: May 1, 2024

Chronic diabetic wounds are the most common complication for patients. Due to high oxidative stress levels affecting entire healing process, treating remains a challenge. Here, we present strategy continuously regulating microenvironment by catalyst-like magnesium-gallate metal-organic framework (Mg-GA MOF) and developing sprayable hydrogel dressing with sodium alginate/chitosan quaternary ammonium salts treat wounds. Chitosan antibacterial properties can prevent bacterial infection. The continuous release of gallic acid (GA) effectively eliminates reactive oxygen species (ROS), reduces stress, accelerates polarization M1-type macrophages M2-type, shortening transition between inflammation proliferative phase maintaining redox balance. Besides, magnesium ions adjuvant therapy promotes vascular regeneration neuronal formation activating expression vascular-associated genes. Sprayable dressings antibacterial, antioxidant, inflammatory regulation rapidly repair promoting neurovascular network reconstruction accelerating re-epithelialization collagen deposition. This study confirms feasibility MOF-contained regulate provides guidance next generation non-drug diabetes dressings.

Language: Английский

Citations

26