Vaginal Epithelial Cell Membrane-Based Phototherapeutic Decoy Confers a “Three-in-One” Strategy to Treat against Intravaginal Infection of Candida albicans DOI

Yijing Lin,

Qingqing Yin,

Dongyan Tian

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12160 - 12175

Published: May 18, 2023

Phototherapy is an effective strategy to control Candida albicans (C. albicans) infection without raising the concern of drug resistance. Despite its effectiveness, a higher dose phototherapeutic power required for C. elimination compared bacteria that have be used, which readily accompanied by off-target heat and toxic singlet oxygen damage normal cells, thus limiting usefulness antifungal applications. Here overcome this, we develop "three-in-one" biomimetic nanoplatform consisting oxygen-dissolved perfluorocarbon camouflaged photosensitizer-loaded vaginal epithelial cell membrane. With membrane coating, capable specifically binding with at superficial or deep epithelium, thereby centering agents on albicans. Meanwhile, coating endows competitively protect healthy cells from candidalysin-medicated cytotoxicity. Upon candidalysin sequestration, pore-forming surface accelerates release preloaded photosensitizer oxygen, resulting in enhanced improved anti-C. efficacy under near-infrared irradiation. In intravaginal albicans-infected murine model, treatment leads significantly decreased burden, particularly when leveraging further elevated phototherapy inhibition. Also, same trends hold true using treat clinical isolates. Overall, this can target bind simultaneously neutralize then transform such toxins are always considered positive part driving enhancing efficacy.

Language: Английский

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter DOI Creative Commons
Ximin Cui, Qifeng Ruan, Xiaolu Zhuo

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

Citations

847
Photothermal conversion and transfer in photothermal therapy: From macroscale to nanoscale DOI Creative Commons
Ya-Tao Ren, Yuying Yan, Hong Qi

et al.

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 308, P. 102753 - 102753

Published: Aug. 16, 2022

Photothermal therapy (PTT) is a promising alternative for benign or even malignant tumors. To improve the selective heating of tumor cells, target-specific photothermal conversion agents are often included, especially nanoparticles. Meanwhile, some indirect methods by manipulating radiation and heat delivery also adopted. Therefore, to gain clear understanding mechanism, controllability PTT, few issues need be clarified, including bioheat transfer, localized collective nanoparticles, etc. In this review, we provide an introduction typical transfer models along with dynamic thermophysical properties biological tissue. On basis, reviewed most recent advances in temperature control PTT from macroscale nanoscale. Most importantly, comprehensive effects nanoparticle clusters provided give insight into mechanism PPT microscale nanoscale point view.

Language: Английский

Citations

113
Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications DOI Creative Commons
Rui Chang, Luyang Zhao, Ruirui Xing

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(8), P. 2688 - 2712

Published: Jan. 1, 2023

An overview of chromopeptide self-assembly is presented to systematically understand this kind newly emerging peptide building block.

Language: Английский

Citations

100
Quantitative Comparison of the Light-to-Heat Conversion Efficiency in Nanomaterials Suitable for Photothermal Therapy DOI Creative Commons
Agnieszka Paściak, Riccardo Marin, Lise Abiven

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(29), P. 33555 - 33566

Published: July 18, 2022

Functional colloidal nanoparticles capable of converting between various energy types are finding an increasing number applications. One the relevant examples concerns light-to-heat-converting that may be useful for localized photothermal therapy cancers. Unfortunately, quantitative comparison and ranking nanoheaters not straightforward as materials different compositions structures have photophysical chemical properties interact differently with biological environment. In terms properties, most information to rank these is light-to-heat conversion efficiency, which, along on absorption capacity material, can used directly compare materials. this work, we evaluate 17 belonging groups (plasmonic, semiconductor, lanthanide-doped nanocrystals, carbon metal oxides). We conclude efficiency alone meaningful enough many similar efficiencies─in range 80-99%─while they significantly differ in their extinction coefficient. therefore constructed qualitative based external which takes into account conventionally defined its capacity. This demonstrated differences samples more meaningfully. Among studied systems, top-ranking were black porous silicon CuS nanocrystals. These results allow us select favorable photo-based theranostics set a new standard characterization nanoheaters.

Language: Английский

Citations

75
Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy DOI

Yongjuan Li,

Yu Zhang,

Ya Dong

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(22)

Published: March 25, 2023

Reactive oxygen species (ROS)-mediated tumor catalytic therapy is typically hindered by gap junction proteins that form cell-to-cell channels to remove cytotoxic ROS, thereby protecting cells from oxidative damage. In this work, a multifunctional nanozyme, FePGOGA, designed and prepared Fe(III)-mediated polymerization (FeP), followed glucose oxidase (GOx) GAP19 peptides co-loading through electrostatic π-π interactions. The FePGOGA nanozyme exhibits excellent cascade peroxidase- glutathione-oxidase-like activities efficiently catalyze hydrogen peroxide conversion hydroxyl radicals convert reduced glutathione oxidized disulfide. loaded GOx starves the tumors aggravates stress decomposition, while block hemichannels inducing degradation of Cx43, thus increasing accumulation intracellular decreasing transport glucose. Furthermore, ROS reacts with primary amines heat shock destroy their structure function, enabling photothermal at widely sought-after mild temperature (mildPTT, ≤45 °C). vivo experiments demonstrate significant antitumor effectof on cal27 xenograft under near-infrared light irradiation. This study demonstrates successful ablation overcome resistance ROS-mediated therapy, providing regulator suppress self-preservation during starvation, mildPTT.

Language: Английский

Citations

66
Peptide Self-assembly: From Ordered to Disordered DOI
Rui Chang, Chengqian Yuan, Peng Zhou

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(3), P. 289 - 301

Published: Jan. 17, 2024

ConspectusBiomolecular self-assembly is a ubiquitous occurrence in nature that gives rise to sophisticated superstructures enable the implementation of complex biological functions. It encompasses both ordered structures, such as DNA double helix, and disordered nucleolus other nonmembranous organelles. In contrast these highly organized which exhibit specific patterns or symmetry, structures are characterized by their flexible randomized molecular organization, provides versatility, dynamicity, adaptability systems contributes complexity functionality living organisms. However, usually exist thermodynamically metastable state. This means unstable difficult observe due short existence time. Achieving through precise control assembly process ensuring stability integrity pose significant challenges. Currently, ongoing research efforts focused on proteins with intrinsically regions (IDRs). structural instability present prohibitive difficulties elucidating multiscale process. Therefore, simple peptides, segment proteins, hold great promise constructing for related research. Since our finding droplet-like occur transiently during peptide (PSA), centered around dynamic evolution supramolecular systems, particularly modulation variety assembled ranging from disordered.In this Account, we narrate recent endeavors formed PSA, spanning structures. We delve into mechanisms regulation, shedding light how peptide-based can be controlled more precisely. Moreover, emphasize functional applications arise To begin, conduct comprehensive overview various types emerge showcasing diverse applications. Following, elaborate discovery development PSA. A mechanistic study multistep processes mediated liquid–liquid phase separation (LLPS) critically emphasized. Ordered different morphologies functions obtained subtly controlling adjusting liquid droplets. particular, have recently developed solid glasses long-range disorder, including noncovalent biomolecular glass based amino acid derivatives, well high-entropy cyclic peptides. demonstrates potential using biologically derived molecules create green sustainable glassy materials.

Language: Английский

Citations

66
Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy DOI
Ping Huang, Yao Yang, Wenyan Wang

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 299, P. 122157 - 122157

Published: May 9, 2023

Language: Английский

Citations

59
Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications DOI Creative Commons

Rongqiu Mu,

Danzhu Zhu,

Sama Abdulmalik

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 181 - 207

Published: Feb. 2, 2024

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances stimuli-responsive functions, promoting function-specific that induced by both internal external stimulations. this review, we demonstrate recent advance in molecular design, self-assembly, functional tailoring, biomedical peptide-based nanomaterials. The strategies on synthesis single, dual, multiple various dimensions are analyzed, regulation active such metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, others discussed. designed temperature-, pH-, ion-, light-, enzyme-, ROS-responsive abilities drug delivery, bioimaging, cancer therapy, gene antibacterial, well wound healing dressing presented This comprehensive review provides detailed methodologies advanced techniques from biology, materials science, nanotechnology, will guide inspire level peptides specific functions applications.

Language: Английский

Citations

56
Dual Glucose/ROS-Sensitive Injectable Adhesive Self-Healing Hydrogel with Photothermal Antibacterial Activity and Modulation of Macrophage Polarization for Infected Diabetic Wound Healing DOI

Xiaoyan Zhou,

Xiaoqun Ning,

Yiwen Chen

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(12), P. 3142 - 3155

Published: Oct. 27, 2023

Antibacterial, anti-inflammatory, and healing-promoting treatment of chronically infected wounds is not only clinical problems to be solved urgently but also important needs related people's livelihood. However, multifunctional hydrogel dressings with highly efficient antibacterial, wound microenvironment sensitive drug release performance still remain a challenge. In this work, dressing was achieved by introducing mussel-like super adhesion catechol groups glucose/ROS-sensitive dynamic phenylboronester bond cross-linking network, which endowed the excellent injectable, self-healing, tissue properties, performance. Additionally, high-efficiency photothermal synergistic antibacterial TP@Ag NPs were prepared introduced into hydrogel. The glucose/ROS responsive borate in network could realize NPs, thereby promoting M2 polarization achieve an anti-inflammatory effect. And excess reactive oxygen (ROS) scavenged effect group ROS-sensitive Moreover, biocompatibility antioxidant shown hydrogels. Finally, fully fill adhere irregular through injection significantly promote diabetic healing vivo sterilization, ROS scavenging ability, modulation macrophage reduce inflammatory response. Thus, it illustrated superiority as advanced functional for healing.

Language: Английский

Citations

51
Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

Citations

31