ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(13), P. 12160 - 12175
Published: May 18, 2023
Phototherapy
is
an
effective
strategy
to
control
Candida
albicans
(C.
albicans)
infection
without
raising
the
concern
of
drug
resistance.
Despite
its
effectiveness,
a
higher
dose
phototherapeutic
power
required
for
C.
elimination
compared
bacteria
that
have
be
used,
which
readily
accompanied
by
off-target
heat
and
toxic
singlet
oxygen
damage
normal
cells,
thus
limiting
usefulness
antifungal
applications.
Here
overcome
this,
we
develop
"three-in-one"
biomimetic
nanoplatform
consisting
oxygen-dissolved
perfluorocarbon
camouflaged
photosensitizer-loaded
vaginal
epithelial
cell
membrane.
With
membrane
coating,
capable
specifically
binding
with
at
superficial
or
deep
epithelium,
thereby
centering
agents
on
albicans.
Meanwhile,
coating
endows
competitively
protect
healthy
cells
from
candidalysin-medicated
cytotoxicity.
Upon
candidalysin
sequestration,
pore-forming
surface
accelerates
release
preloaded
photosensitizer
oxygen,
resulting
in
enhanced
improved
anti-C.
efficacy
under
near-infrared
irradiation.
In
intravaginal
albicans-infected
murine
model,
treatment
leads
significantly
decreased
burden,
particularly
when
leveraging
further
elevated
phototherapy
inhibition.
Also,
same
trends
hold
true
using
treat
clinical
isolates.
Overall,
this
can
target
bind
simultaneously
neutralize
then
transform
such
toxins
are
always
considered
positive
part
driving
enhancing
efficacy.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Advances in Colloid and Interface Science,
Journal Year:
2022,
Volume and Issue:
308, P. 102753 - 102753
Published: Aug. 16, 2022
Photothermal
therapy
(PTT)
is
a
promising
alternative
for
benign
or
even
malignant
tumors.
To
improve
the
selective
heating
of
tumor
cells,
target-specific
photothermal
conversion
agents
are
often
included,
especially
nanoparticles.
Meanwhile,
some
indirect
methods
by
manipulating
radiation
and
heat
delivery
also
adopted.
Therefore,
to
gain
clear
understanding
mechanism,
controllability
PTT,
few
issues
need
be
clarified,
including
bioheat
transfer,
localized
collective
nanoparticles,
etc.
In
this
review,
we
provide
an
introduction
typical
transfer
models
along
with
dynamic
thermophysical
properties
biological
tissue.
On
basis,
reviewed
most
recent
advances
in
temperature
control
PTT
from
macroscale
nanoscale.
Most
importantly,
comprehensive
effects
nanoparticle
clusters
provided
give
insight
into
mechanism
PPT
microscale
nanoscale
point
view.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(29), P. 33555 - 33566
Published: July 18, 2022
Functional
colloidal
nanoparticles
capable
of
converting
between
various
energy
types
are
finding
an
increasing
number
applications.
One
the
relevant
examples
concerns
light-to-heat-converting
that
may
be
useful
for
localized
photothermal
therapy
cancers.
Unfortunately,
quantitative
comparison
and
ranking
nanoheaters
not
straightforward
as
materials
different
compositions
structures
have
photophysical
chemical
properties
interact
differently
with
biological
environment.
In
terms
properties,
most
information
to
rank
these
is
light-to-heat
conversion
efficiency,
which,
along
on
absorption
capacity
material,
can
used
directly
compare
materials.
this
work,
we
evaluate
17
belonging
groups
(plasmonic,
semiconductor,
lanthanide-doped
nanocrystals,
carbon
metal
oxides).
We
conclude
efficiency
alone
meaningful
enough
many
similar
efficiencies─in
range
80-99%─while
they
significantly
differ
in
their
extinction
coefficient.
therefore
constructed
qualitative
based
external
which
takes
into
account
conventionally
defined
its
capacity.
This
demonstrated
differences
samples
more
meaningfully.
Among
studied
systems,
top-ranking
were
black
porous
silicon
CuS
nanocrystals.
These
results
allow
us
select
favorable
photo-based
theranostics
set
a
new
standard
characterization
nanoheaters.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(22)
Published: March 25, 2023
Reactive
oxygen
species
(ROS)-mediated
tumor
catalytic
therapy
is
typically
hindered
by
gap
junction
proteins
that
form
cell-to-cell
channels
to
remove
cytotoxic
ROS,
thereby
protecting
cells
from
oxidative
damage.
In
this
work,
a
multifunctional
nanozyme,
FePGOGA,
designed
and
prepared
Fe(III)-mediated
polymerization
(FeP),
followed
glucose
oxidase
(GOx)
GAP19
peptides
co-loading
through
electrostatic
π-π
interactions.
The
FePGOGA
nanozyme
exhibits
excellent
cascade
peroxidase-
glutathione-oxidase-like
activities
efficiently
catalyze
hydrogen
peroxide
conversion
hydroxyl
radicals
convert
reduced
glutathione
oxidized
disulfide.
loaded
GOx
starves
the
tumors
aggravates
stress
decomposition,
while
block
hemichannels
inducing
degradation
of
Cx43,
thus
increasing
accumulation
intracellular
decreasing
transport
glucose.
Furthermore,
ROS
reacts
with
primary
amines
heat
shock
destroy
their
structure
function,
enabling
photothermal
at
widely
sought-after
mild
temperature
(mildPTT,
≤45
°C).
vivo
experiments
demonstrate
significant
antitumor
effectof
on
cal27
xenograft
under
near-infrared
light
irradiation.
This
study
demonstrates
successful
ablation
overcome
resistance
ROS-mediated
therapy,
providing
regulator
suppress
self-preservation
during
starvation,
mildPTT.
Accounts of Chemical Research,
Journal Year:
2024,
Volume and Issue:
57(3), P. 289 - 301
Published: Jan. 17, 2024
ConspectusBiomolecular
self-assembly
is
a
ubiquitous
occurrence
in
nature
that
gives
rise
to
sophisticated
superstructures
enable
the
implementation
of
complex
biological
functions.
It
encompasses
both
ordered
structures,
such
as
DNA
double
helix,
and
disordered
nucleolus
other
nonmembranous
organelles.
In
contrast
these
highly
organized
which
exhibit
specific
patterns
or
symmetry,
structures
are
characterized
by
their
flexible
randomized
molecular
organization,
provides
versatility,
dynamicity,
adaptability
systems
contributes
complexity
functionality
living
organisms.
However,
usually
exist
thermodynamically
metastable
state.
This
means
unstable
difficult
observe
due
short
existence
time.
Achieving
through
precise
control
assembly
process
ensuring
stability
integrity
pose
significant
challenges.
Currently,
ongoing
research
efforts
focused
on
proteins
with
intrinsically
regions
(IDRs).
structural
instability
present
prohibitive
difficulties
elucidating
multiscale
process.
Therefore,
simple
peptides,
segment
proteins,
hold
great
promise
constructing
for
related
research.
Since
our
finding
droplet-like
occur
transiently
during
peptide
(PSA),
centered
around
dynamic
evolution
supramolecular
systems,
particularly
modulation
variety
assembled
ranging
from
disordered.In
this
Account,
we
narrate
recent
endeavors
formed
PSA,
spanning
structures.
We
delve
into
mechanisms
regulation,
shedding
light
how
peptide-based
can
be
controlled
more
precisely.
Moreover,
emphasize
functional
applications
arise
To
begin,
conduct
comprehensive
overview
various
types
emerge
showcasing
diverse
applications.
Following,
elaborate
discovery
development
PSA.
A
mechanistic
study
multistep
processes
mediated
liquid–liquid
phase
separation
(LLPS)
critically
emphasized.
Ordered
different
morphologies
functions
obtained
subtly
controlling
adjusting
liquid
droplets.
particular,
have
recently
developed
solid
glasses
long-range
disorder,
including
noncovalent
biomolecular
glass
based
amino
acid
derivatives,
well
high-entropy
cyclic
peptides.
demonstrates
potential
using
biologically
derived
molecules
create
green
sustainable
glassy
materials.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
35, P. 181 - 207
Published: Feb. 2, 2024
Peptide
molecules
have
design
flexibility,
self-assembly
ability,
high
biocompatibility,
good
biodegradability,
and
easy
functionalization,
which
promote
their
applications
as
versatile
biomaterials
for
tissue
engineering
biomedicine.
In
addition,
the
functionalization
of
self-assembled
peptide
nanomaterials
with
other
additive
components
enhances
stimuli-responsive
functions,
promoting
function-specific
that
induced
by
both
internal
external
stimulations.
this
review,
we
demonstrate
recent
advance
in
molecular
design,
self-assembly,
functional
tailoring,
biomedical
peptide-based
nanomaterials.
The
strategies
on
synthesis
single,
dual,
multiple
various
dimensions
are
analyzed,
regulation
active
such
metal/metal
oxide,
DNA/RNA,
polysaccharides,
photosensitizers,
2D
materials,
others
discussed.
designed
temperature-,
pH-,
ion-,
light-,
enzyme-,
ROS-responsive
abilities
drug
delivery,
bioimaging,
cancer
therapy,
gene
antibacterial,
well
wound
healing
dressing
presented
This
comprehensive
review
provides
detailed
methodologies
advanced
techniques
from
biology,
materials
science,
nanotechnology,
will
guide
inspire
level
peptides
specific
functions
applications.
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(12), P. 3142 - 3155
Published: Oct. 27, 2023
Antibacterial,
anti-inflammatory,
and
healing-promoting
treatment
of
chronically
infected
wounds
is
not
only
clinical
problems
to
be
solved
urgently
but
also
important
needs
related
people's
livelihood.
However,
multifunctional
hydrogel
dressings
with
highly
efficient
antibacterial,
wound
microenvironment
sensitive
drug
release
performance
still
remain
a
challenge.
In
this
work,
dressing
was
achieved
by
introducing
mussel-like
super
adhesion
catechol
groups
glucose/ROS-sensitive
dynamic
phenylboronester
bond
cross-linking
network,
which
endowed
the
excellent
injectable,
self-healing,
tissue
properties,
performance.
Additionally,
high-efficiency
photothermal
synergistic
antibacterial
TP@Ag
NPs
were
prepared
introduced
into
hydrogel.
The
glucose/ROS
responsive
borate
in
network
could
realize
NPs,
thereby
promoting
M2
polarization
achieve
an
anti-inflammatory
effect.
And
excess
reactive
oxygen
(ROS)
scavenged
effect
group
ROS-sensitive
Moreover,
biocompatibility
antioxidant
shown
hydrogels.
Finally,
fully
fill
adhere
irregular
through
injection
significantly
promote
diabetic
healing
vivo
sterilization,
ROS
scavenging
ability,
modulation
macrophage
reduce
inflammatory
response.
Thus,
it
illustrated
superiority
as
advanced
functional
for
healing.