Deleted Journal,
Journal Year:
2024,
Volume and Issue:
32(2), P. 200809 - 200809
Published: April 29, 2024
Oncolytic
virotherapy
represents
a
promising
approach
in
cancer
immunotherapy.
The
primary
delivery
method
for
oncolytic
viruses
(OVs)
is
intratumoral
injection,
which
apparently
limits
their
clinical
application.
For
patients
with
advanced
disseminated
metastasis,
systemic
administration
considered
the
optimal
approach.
However,
direct
of
naked
through
intravenous
injection
presents
challenges,
including
rapid
clearance
by
immune
system,
inadequate
accumulation
tumors,
and
significant
side
effects.
Consequently,
development
drug
strategies
has
led
to
emergence
various
bio-materials
serving
as
viral
vectors,
thereby
improving
anti-tumor
efficacy
virotherapy.
This
review
provides
an
overview
innovative
delivering
OVs,
focus
on
nanoparticle-based
or
cell-based
systems.
Recent
pre-clinical
studies
are
examined
highlight
enhanced
using
these
novel
platforms.
In
addition,
prevalent
challenges
current
research
briefly
discussed,
potential
solutions
proposed.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(12), P. 19691 - 19721
Published: Nov. 15, 2022
The
prominence
of
photodynamic
therapy
(PDT)
in
treating
superficial
skin
cancer
inspires
innovative
solutions
for
its
congenitally
deficient
shadow
penetration
the
visible-light
excitation.
X-ray-induced
(X-PDT)
has
been
proven
to
be
a
successful
technique
reforming
conventional
PDT
deep-seated
tumors
by
creatively
utilizing
penetrating
X-rays
as
external
excitation
sources
and
witnessed
rapid
developments
over
past
several
years.
Beyond
proof-of-concept
demonstration,
recent
advances
X-PDT
have
exhibited
trend
minimizing
X-ray
radiation
doses
quite
low
values.
As
such,
scintillating
materials
used
bridge
photosensitizers
play
significant
role,
do
diverse
well-designed
irradiation
modes
smart
strategies
improving
tumor
microenvironment.
Here
this
review,
we
provide
comprehensive
summary
achievements
highlight
trending
efforts
using
radiation.
We
first
describe
concept
relationships
with
radiodynamic
radiotherapy
then
dissect
mechanism
absorption
conversion
materials,
reactive
oxygen
species
evaluation
X-PDT,
side
effects
clinical
concerns
on
Finally,
discuss
detailed
overview
progress
regarding
low-dose
present
perspectives
possible
translation.
It
is
expected
that
pursuit
will
facilitate
breakthroughs,
both
fundamentally
clinically,
effective
treatment
near
future.
Oncolytic
viruses
(OVs)
as
one
promising
antitumor
methods
have
made
important
contributions
to
tumor
immunotherapy,
which
arouse
increasing
attention.
They
provide
the
dual
mechanisms
including
direct
killing
effect
toward
cells
and
immune
activation
for
elevating
responses,
been
proved
in
many
preclinical
studies.
Especially,
natural
or
genetically
modified
clinical
preparations
emerged
a
new
approach
objective
oncology
treatment.
The
approval
of
talimogene
laherparepvec
(T-VEC)
by
U.S.
Food
Drug
Administration
(FDA)
therapy
advanced
melanoma
could
be
considered
milestone
achievement
translation
OV.
In
this
review,
we
first
discussed
OVs
with
an
emphasis
on
targeting,
replication,
propagation.
We
further
outlined
state
art
current
underlined
activated
biological
effects
especially
immunity.
More
significantly,
enhanced
responses
based
were
systematically
from
different
perspectives
such
combination
genetic
engineering
OVs,
integration
nanobiotechnology
nanoparticles,
antiviral
response
counteraction,
where
their
principles
shed
light
on.
development
clinics
was
also
highlighted
analyze
actuality
concerns
OV
applications
trials.
At
last,
future
challenges
already
widely
accepted
treatment
means
discussed.
This
review
will
systematic
deep
insight
into
offer
opportunities
guidance
pathways
drive
translation.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(48)
Published: Nov. 29, 2023
Biocompatible
swarming
magnetic
nanorobots
that
work
in
blood
vessels
for
safe
and
efficient
targeted
thrombolytic
therapy
vivo
are
demonstrated.
This
is
achieved
by
using
beads
elaborately
grafted
with
heparinoid-polymer
brushes
(HPBs)
upon
the
application
of
an
alternating
field
B
(
t
).
Because
dense
surface
charges
bestowed
HPBs,
demonstrate
reversible
agglomeration-free
reconfigurations,
low
hemolysis,
anti-bioadhesion,
self-anticoagulation
high-ionic-strength
environments.
They
confirmed
vitro
to
perform
synergistic
thrombolysis
efficiently
“motile-targeting”
drug
delivery
mechanical
destruction.
Moreover,
completion
removal
),
disassemble
into
dispersed
particles
blood,
allowing
them
safely
participate
circulation
be
phagocytized
immune
cells
without
apparent
organ
damage
or
inflammatory
lesion.
provides
a
rational
multifaceted
HPB
biointerfacing
design
strategy
biomedical
general
motile
platform
deliver
drugs
therapies.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(24)
Published: June 12, 2024
Lung
metastasis
poses
a
formidable
challenge
in
the
realm
of
cancer
treatment,
with
conventional
chemotherapy
often
falling
short
due
to
limited
targeting
and
low
accumulation
lungs.
Here,
we
show
microrobot
approach
using
motile
algae
for
localized
delivery
drug-loaded
nanoparticles
address
lung
challenges.
The
biohybrid
[denoted
“algae-NP(DOX)-robot”]
combines
green
microalgae
red
blood
cell
membrane–coated
containing
doxorubicin,
representative
chemotherapeutic
drug.
Microalgae
provide
autonomous
propulsion
lungs,
leveraging
controlled
drug
release
enhanced
dispersion
exert
antimetastatic
effects.
Upon
intratracheal
administration,
algae-NP(DOX)-robots
efficiently
transport
their
payload
deep
into
lungs
while
maintaining
continuous
motility.
This
strategy
leads
rapid
distribution,
improved
tissue
accumulation,
prolonged
retention
compared
passive
free
controls.
In
melanoma
model,
exhibit
substantial
improvement
therapeutic
efficacy,
reducing
metastatic
burden
extending
survival
control
groups.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(15)
Published: Jan. 25, 2023
Abstract
Untethered
mobile
micro‐/nanomotors
(MNMs),
as
newly‐emerging
attractive
and
versatile
nanotechnologies,
are
expected
to
be
the
next‐generation
disease
treatment
tools,
for
breaking
through
limitations
of
conventional
passive
drug
delivery
manner.
However,
advances
in
these
fascinating
platforms
have
been
hampered
by
complexity
biological
environment
particularity
microenvironment.
Consequently,
specific
design
strategies
clinical
imaging
techniques
essential
ensure
high‐efficiency
biomedical
MNMs
on
actuation,
targeting,
localization,
therapy
when
performing
assigned
vivo
tasks.
This
review
thus
comprehensively
addresses
three
aspects
MNMs,
including
design,
imaging,
treatment,
highlighting
intelligent
with
biomimetic
functionality
chemotactic
capability,
emphasizing
applicability
different
techniques,
focusing
various
proof‐of‐concept
studies
based
physiological
characteristics
major
diseases.
In
addition,
key
challenges
current
addressed,
which
may
inspire
future
research
facilitate
translation
toward
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14196 - 14204
Published: July 26, 2023
Microrobots
are
being
explored
for
biomedical
applications,
such
as
drug
delivery,
biological
cargo
transport,
and
minimally
invasive
surgery.
However,
current
efforts
largely
focus
on
proof-of-concept
studies
with
nontranslatable
materials
through
a
"design-and-apply"
approach,
limiting
the
potential
clinical
adaptation.
While
these
have
been
key
to
advancing
microrobot
technologies,
we
believe
that
distinguishing
capabilities
of
microrobots
will
be
most
readily
brought
patient
bedsides
"design-by-problem"
which
involves
focusing
unsolved
problems
inform
design
practical
capabilities.
As
outlined
below,
propose
translation
accelerated
by
judicious
choice
target
improved
delivery
considerations,
rational
selection
translation-ready
biomaterials,
ultimately
reducing
burden
enhancing
efficacy
therapeutic
drugs
difficult-to-treat
diseases.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(3)
Published: Sept. 1, 2023
Abstract
Extracellular
vesicles
(EVs)
have
inherent
advantages
over
cell‐based
therapies
in
regenerative
medicine
because
of
their
cargos
abundant
bioactive
cues.
Several
strategies
are
proposed
to
tune
EVs
production
vitro.
However,
it
remains
a
challenge
for
manipulation
vivo,
which
poses
significant
difficulties
EVs‐based
that
aim
promote
tissue
regeneration,
particularly
long‐term
treatment
diseases
like
peripheral
neuropathy.
Herein,
superparamagnetic
nanocomposite
scaffold
capable
controlling
on‐demand
is
constructed
by
incorporating
polyethyleneglycol/polyethyleneimine
modified
nanoparticles
into
polyacrylamide/hyaluronic
acid
double‐network
hydrogel
(Mag‐gel).
The
Mag‐gel
highly
sensitive
rotating
magnetic
field
(RMF),
and
can
act
as
mechano‐stimulative
platform
exert
micro/nanoscale
forces
on
encapsulated
Schwann
cells
(SCs),
an
essential
glial
cell
supporting
nerve
regeneration.
By
switching
the
ON/OFF
state
RMF,
scale
up
local
SCs‐derived
(SCs‐EVs)
both
vitro
vivo.
Further
transcriptome
sequencing
indicates
enrichment
transcripts
favorable
axon
growth,
angiogenesis,
inflammatory
regulation
SCs‐EVs
with
ultimately
results
optimized
repair
Overall,
this
research
provides
noninvasive
remotely
time‐scheduled
method
fine‐tuning
accelerate
including
nerves.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
15(19), P. 8491 - 8507
Published: Jan. 1, 2023
Untethered
robots
in
the
size
range
of
micro/nano-scale
offer
unprecedented
access
to
hard-to-reach
areas
body.
In
these
challenging
environments,
autonomous
task
completion
capabilities
micro/nanorobots
have
been
subject
research
recent
years.
However,
most
studies
presented
preliminary
vitro
results
that
can
significantly
differ
under
vivo
settings.
Here,
we
focus
on
conducted
with
animal
models
reveal
current
status
micro/nanorobotic
applications
real-world
conditions.
By
a
categorization
based
target
locations,
highlight
main
strategies
employed
organs
and
other
body
parts.
We
also
discuss
key
challenges
require
interest
before
successful
translation
clinic.
