Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(22)
Published: March 9, 2023
The
development
of
blood-brain
barrier
(BBB)-crossing
phototheranostic
agents
in
second
near-infrared
window
(NIR-II),
especially
the
range
1500-1700
nm
(NIR-IIb),
affords
great
opportunities
for
glioblastoma
(GBM)
management.
Herein,
an
organic
assembly
(denoted
as
LET-12)
with
maximum
absorption
peak
at
1400
and
emission
1512
trailing
over
1700
through
self-assembly
small
molecule
IR-1064
is
designed
subsequently
decorated
choline
acetylcholine
analogs.
LET-12
can
effectively
cross
BBB
brain's
choline-like
receptors-mediated
transcytosis
accumulated
tumor
tissues,
thus
achieving
fluorescence/photoacoustic
(FL/PA)
duplex
imaging
orthotopic
GBM
≈3.0
mm
depth
a
superior
tumor-to-normal
tissue
signal
ratio
(20.93
±
0.59
FL
32.63
1.16
PA
imaging,
respectively).
Owing
to
its
good
photothermal
conversion
ability,
also
serve
agent,
obvious
repression
murine
model
after
once
treatment.
findings
indicate
that
holds
potential
BBB-crossing
NIR-IIb
phototheranostics
GBM.
This
strategy
molecules
opens
new
avenue
construction
phototheranostics.
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(8), P. 2164 - 2173
Published: July 14, 2023
Real-time
monitoring
of
kidney
dysfunction
in
vivo
is
great
significance
to
the
diagnosis
renal
diseases
and
preservation
human
health,
which
can
be
achieved
by
second
near-infrared
(NIR-II)
fluorescence
imaging.
However,
development
NIR-II
imaging
for
study
has
been
impeded
a
lack
renal-clearable
luminescent
materials
with
good
optical
properties.
This
synthesized
renally
clear
gold
nanoclusters
(Au
NCs)
both
excitation
emission
first
time.
Imaging
light
offers
deep
tissue
penetration,
high
resolution,
signal-to-background
ratio.
Additionally,
developed
Au
NCs
have
quantum
yields
as
1.4–2.0%,
nearly
10-fold
higher
than
that
previous
clearable
emitting
materials.
These
salient
merits
allow
realize
high-resolution
imaging,
well
induced
ischemia–reperfusion
unilateral
ureteral
obstruction.
Our
findings
provide
new
candidate
powerful
tool
accurate
diseases.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 4, 2024
Constructing
J-aggregated
organic
dyes
represents
a
promising
strategy
for
obtaining
biomedical
second
near-infrared
(NIR-II)
emissive
materials,
as
they
exhibit
red-shifted
spectroscopic
properties
upon
assembly
into
nanoparticles
(NPs)
in
aqueous
environments.
However,
currently
available
NIR-II
J-aggregates
primarily
rely
on
specific
molecular
backbones
with
intricate
design
strategies
and
are
susceptible
to
fluorescence
quenching
during
assembly.
A
facile
approach
constructing
bright
using
prevalent
donor-acceptor
(D-A)
molecules
is
still
lacking.
In
this
study,
we
present
method
that
transforms
D-A
by
simply
bending
the
molecule
through
introducing
methyl
group,
enabling
high-performance
phototheranostics.
The
TAA-BT-CN
exhibits
hypsochromic-shift
absorption
forming
H-aggregated
NPs,
while
designed
mTAA-BT-CN
bent
structure
demonstrates
bathochromic
shift
of
over
100
nm
leading
much
enhanced
emission
beyond
1100
nm.
With
respect
its
counterpart
aggregation-caused
(ACQ)
phenomenon,
NPs
7-fold
increase
owing
their
aggregation-induced
(AIE)
property
well
efficient
generation
heat
reactive
oxygen
species
under
808
light
excitation.
Finally,
employed
whole-body
blood
vessel
imaging
technology
imaging-guided
tumor
phototherapies.
This
study
will
facilitate
flourishing
advancement
based
D-A-type
molecules.
