Recent Progress in Implantable Drug Delivery Systems

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 20, 2024

Abstract In recent years, tremendous effort is devoted to developing platforms, such as implantable drug delivery systems (IDDSs), with temporally and spatially controlled release capabilities improved adherence. IDDSs have multiple advantages: i) the timing location of can be by patients using specific stimuli (light, sound, electricity, magnetism, etc.). Some intelligent “closed‐loop” IDDS even realize self‐management without human participation. ii) enable continuous stable drugs over a long period (months years) iii) administer directly lesion, thereby helping reduce dosage side effects. iv) personalized according patient needs. The high demand for has prompted scientists make efforts develop IDDS. this review, several common stimulus‐responsive mechanisms including endogenous (e.g., pH, reactive oxygen species, proteins, etc.) exogenous light, etc.), are given in detail. Besides, types reported years reviewed, various based on above mechanisms, radio frequency‐controlled IDDS, self‐powered etc. Finally, advantages disadvantages bottleneck problems, possible solutions analyzed provide directions subsequent research.

Language: Английский

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Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18252 - 18267

Published: April 6, 2024

Nitric oxide (NO) intervenes, that is, a potential treatment strategy, and has attracted wide attention in the field of tumor therapy. However, therapeutic effect NO is still poor, due to its short half-life instability. Therapeutic concentration ranges should be delivered target tissue sites, cell, even subcellular organelles control generation. Mitochondria have been considered major cancer therapy for their essential roles cell metabolism apoptosis. In this study, mesoporous silicon-coated gold nanorods encapsulated with mitochondria targeted thermosensitive lipid layer (AuNR@MSN-lipid-DOX) served as carrier load prodrug (BNN6) build near-infrared-triggered synergetic photothermal NO-chemotherapy platform (AuNR@MSN(BNN6)-lipid-DOX). The core AuNR@MSN exhibited excellent conversion capability high loading efficiency terms BNN6, reaching value 220 mg/g (w/w), which achieved precise release NO. outer biocompatible layer, comprising phospholipid DPPC mitochondrial-targeted DSPE-PEG2000-DOX, guided whole nanoparticle 4T1 cells observed through confocal microscopy. mitochondria, nanoparticles increased local temperature over 42 °C under NIR irradiation, from BNN6 detected by probe DSPE-PEG2000-DOX significantly inhibited vitro vivo (PTT)–NO therapy–chemotherapy modes. built NIR-triggered combination nanoplatform can serve strategy multimodal collaboration.

Language: Английский

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Advanced sustainable triboelectric nanogenerators for biomedical and clinical applications: In vivo treatments, in vitro therapeutics, and assisted rehabilitations

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161042 - 161042

Published: Feb. 1, 2025

Language: Английский

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A High Performance Triboelectric Nanogenerator Based on MXene/Graphene Oxide Electrode for Glucose Detection

Materials, Journal Year: 2023, Volume and Issue: 16(2), P. 841 - 841

Published: Jan. 15, 2023

A smart sensing platform based on a triboelectric nanogenerator (TENG) possesses various advantages such as self-powering, convenience, real-time and biocompatibility. However, the detection limit of TENG-based sensor is required to be improved. In this study, high performance glucose was proposed by using Ti3C2Tx (MXene)/graphene oxide (GO) composite electrode. The MXene GO nanosheets are popular 2D materials which possessed conductivity rich surface functional group. MXene/GO thin films were prepared through electrostatic self-assembly technology, can effectively impede agglomeration two nanoflakes. as-prepared film presented outstanding mechanical property. To figure out relationship between nanostructure TENG, series MXene/GO-based TENG with different sizes characterized. As result, 400 nm demonstrated highest output performance. Subsequently, optimized used in application without assistance enzyme. This simple flexible shows promising potential biosensors non-invasive health monitoring.

Language: Английский

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Device physics and application prospect of the emerging high-voltage supply technology arising from triboelectric nanogenerator

Nano Energy, Journal Year: 2023, Volume and Issue: 119, P. 109010 - 109010

Published: Oct. 26, 2023

Language: Английский

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Hydrogel-assisted microfluidic spinning of stretchable fibers via fluidic and interfacial self-adaptations

Science Advances, Journal Year: 2023, Volume and Issue: 9(42)

Published: Oct. 20, 2023

Stretchable polymeric fibers have enormous potential, but their production requires rigorous environmental controls and considerable resource consumption. It's also challenging for elastic polymers with high performance poor spinnability, such as silicones like polydimethylsiloxane Ecoflex. We present a hydrogel-assisted microfluidic spinning (HAMS) method to address these challenges by encapsulating prepolymers within arbitrarily long, protective, sacrificable hydrogel fibers. By designing simple apparatuses manipulating the fluidic interfacial self-adaptations of oil/water flows, we successfully produce widely controllable diameter (0.04 3.70 millimeters), notable length, quality (e.g., smooth surface, whole-length uniformity, rounded section), remarkable stretchability (up 1300%) regardless spinnability. Uniquely, this allows an easy, effective, reshaping helical exceptional mechanical compliance. deeply reveal mechanisms in producing demonstrate potential textile components, optoelectronic devices, actuators. The HAMS would be powerful tool mass-producing high-quality stretchable

Language: Английский

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Manganese oxide-modified bismuth oxychloride piezoelectric nanoplatform with multiple enzyme-like activities for cancer sonodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 640, P. 839 - 850

Published: March 7, 2023

Language: Английский

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Emerging trends in materials and devices‐based electric stimulation therapy for tumors

BMEMat, Journal Year: 2023, Volume and Issue: 1(3)

Published: July 14, 2023

Abstract Electrical stimulation (ES), as one of the physical therapy modalities for tumors, has attracted extensive attention researchers due to its promising efficacy. With continuous development material science, nanotechnology, and micro/nano processing techniques, novel electroactive nanomaterials delicately designed devices have emerged realize innovative ES therapies, which provide more possibilities approaches tumor treatment. Meanwhile, exploring molecular biological mechanisms underlying different affecting cells their immune microenvironment is also an unresolved hotspot emerging from current biomedical engineering research. Focusing on above research interests, in this review, we systematically summarized effects parameters subcellular structure (TIME) conjunction with involved signaling pathways. In addition, reviewed latest progress self‐powered therapy. Finally, prospects electrostimulation are discussed, bringing inspiration new strategies future.

Language: Английский

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Manganese-Doped Potassium Chloride Nanoelectrodes to Potentiate Electrochemical Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(16), P. 10885 - 10901

Published: April 8, 2024

Hypochlorous acid (HClO), as a powerful oxidizer, is obtained from the oxidation of Cl- ions during electrochemical therapy (EChT) process for cancer therapy. However, extracellular generated HClO inadequate to inhibit effective tumor cell death. Herein, manganese-doped potassium chloride nanocubes (MPC NCs) fabricated and modified with amphipathic polymer PEG (PMPC function massive three-dimensional nanoelectrodes (NEs) were developed enhance generation immunotherapy under an alternating electric field. Under square-wave current (AC) field, was boosted by PMPC NEs due enlarged active surface area, enhanced mass transfer rate, improved electrocatalytic activity. Notably, upregulated intracellular concentration induce robust immunogenic death (ICD) AC Meanwhile, electric-triggered release Mn2+ effectively stimulated dendritic cells (DCs) maturation. In vivo results illustrated that PMPC-mediated EChT inhibited growth triggered promotion immune response regulate microenvironment. Based on potent antitumor immunity, further combined checkpoint inhibitor (αCTLA-4) realize EChT-immunotherapy, which demonstrated inhibition primary tumors abscopal effect distant tumors. To summarize, our work highlights application electrochemical-immunotherapy technology in

Language: Английский

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Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 15, 2024

Abstract Background In the tumor immune microenvironment (TIME), triggering receptor expressed on myeloid cells 2 (trem2) is widely considered to be a crucial molecule tumor-associated macrophages(TAMs). Multiple studies have shown that trem2 may function as an checkpoint in various malignant tumors, mediating evasion. However, its specific molecular mechanisms, especially glioma, remain elusive. Methods Lentivirus was transfected establish with stable knockdown of trem2. A Transwell system used for segregated coculture glioma and microglia. Western blotting, quantitative real-time polymerase chain reaction (qRT‒PCR), immunofluorescence (IF) were measure expression levels target proteins. The proliferation, invasion, migration detected by colony formation, cell counting kit-8 (CCK8), 5-ethynyl-2’-deoxyuridine (EdU) transwell assays. cycle, apoptosis rate reactive oxygen species (ROS) level assessed using flow cytometry comet assay tube formation detect DNA damage angiogenesis activity, respectively. Gl261 lines C57BL/6 mice construct orthotopic transplantation model. Results Trem2 highly overexpressed TAMs. Knocking down microglia suppressed growth activity vivo vitro. Mechanistically, promoted proinflammatory inhibited anti-inflammatory activating jak2/stat1 inhibiting NF-κB p50 signaling pathway. produced high concentrations nitric oxide (NO) cytokines TNF-α, IL-6, IL-1β, caused further cells. Conclusions Our findings revealed plays significant role TIME gliomas. Knockdown might help improve efficiency delaying progression provide new ideas treatment glioma.

Language: Английский

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