Journal of Innovative Optical Health Sciences,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
The
fluorescence
imaging
(FLI)
in
the
second
near-infrared
window
(NIR-II,
1000–1700[Formula:
see
text]nm)
has
attracted
considerable
attention
past
decade.
In
contrast
to
conventional
NIR-I
excitation
(808[Formula:
text]nm/980[Formula:
text]nm),
FLI
with
NIR-II
(1064[Formula:
text]nm/other
wavelength
beyond
1000[Formula:
can
afford
deeper
tissue
penetration
depth
high
clarity
due
merits
of
suppressed
photon
scattering
and
diminished
autofluorescence.
this
review,
we
have
summarized
excitable/emissive
organic/polymeric
fluorophores
recently
developed.
characteristics
these
such
as
chemical
structures
photophysical
properties
also
been
critically
discussed.
Furthermore,
latest
development
noninvasive
vivo
was
highlighted.
ideal
results
emphasized
importance
enabling
deep
high-resolution
imaging.
Finally,
a
perspective
on
challenges
prospects
We
expected
review
will
be
served
source
inspiration
for
researchers,
stimulating
creation
novel
excitable
fostering
bioimaging
applications.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Abstract
Glioblastoma
(GBM)
stands
as
the
most
aggressive
malignant
brain
tumor,
characterized
by
poor
prognosis,
high
recurrence
rate,
and
resistance
to
multiple
therapies,
posing
a
significant
clinical
challenge.
Here,
hierarchical
targeting
platform
is
presented
for
NIR‐II
photoacoustic
(PA)
imaging‐guided
photo‐chemo
synergistic
immunotherapy
of
GBM.
A
new
molecular
probe
developed
with
exceptional
light‐harvesting
capabilities
enhanced
motion,
boosting
both
photothermal
conversion
PA
signal.
This
probe,
combined
thermo‐responsive
prodrug,
assembled
into
nanoparticles
that
are
further
camouflaged
tumor
cell
membranes
bioorthogonally
modified
transferrin‐mimicking
peptide,
facilitating
blood‐brain
barrier
penetration
GBM
targeting.
High‐contrast
imaging
allows
precise
detection
delineation
GBM,
providing
accurate
guidance
subsequent
treatment.
The
light‐triggered
effect,
coupled
hyperthermia‐activated
significantly
induces
immunogenic
death,
enhancing
tumor‐killing
efficiency
amplifying
anti‐tumor
immune
response.
self‐synergistic
not
only
stimulates
robust
immunity
inhibits
primary
growth
but
also
prevents
post‐surgical
recurrence,
prolonging
survival
time.
work
exemplifies
novel
paradigm
tackling
diagnostic
therapeutic
challenges
posed
deeply
seated
poorly
tumors.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(33)
Published: April 13, 2024
Near-Infrared-II
(NIR-II)
spans
wavelengths
between
1,000
to
1,700
nanometers,
featuring
deep
tissue
penetration
and
reduced
scattering
absorption
characteristics,
providing
robust
support
for
cancer
treatment
tumor
imaging
research.
This
review
explores
the
utilization
of
activatable
NIR-II
photodiagnosis
phototherapy
based
on
microenvironments
(e.
g.,
reactive
oxygen
species,
pH,
glutathione,
hypoxia)
external
stimulation
laser,
ultrasound,
photothermal)
precise
imaging.
Special
emphasis
is
placed
advancements
advantages
nanomedicines
in
novel
therapeutic
modalities
like
photodynamic
therapy,
photothermal
photoacoustic
encompasses
achieving
penetration,
real-time
monitoring
process,
obtaining
high-resolution,
high
signal-to-noise
ratio
images
even
at
low
material
concentrations.
Lastly,
from
a
clinical
perspective,
challenges
faced
by
are
discussed,
alongside
potential
strategies
overcome
these
hurdles.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 5, 2024
Abstract
Glioblastoma
(GBM)
is
a
highly
malignant
intracranial
tumor
with
limited
treatment
options.
Bispecific
T‐cell
engagers
(BiTEs)
are
being
explored
for
GBM
treatment,
but
their
success
hindered
by
inadequate
T
cell
infiltration
and
activation
due
to
the
acidic
immunosuppressive
microenvironment.
Photothermal
immunotherapy
lyses
tumors
activates
immune
responses,
complementing
BiTEs.
This
study
innovatively
employs
donor
engineering
strategy
develop
hemicyanine
dyes
(Hcys)
that
emit
from
near‐infrared
(NIR)
I
NIR
II.
The
Hcy
excellent
properties
encapsulated
in
an
amphiphilic
micelle,
forming
nano
assembly
lactate
oxidase
(PLH1100).
PLH1100
exhibits
spectral
absorption
at
980
nm,
photothermal
conversion
efficiency
of
58.7%,
capability
NIR‐II
imaging.
Besides
ablation,
regulates
lactic
acid
metabolism
immunogenic
death,
improving
microenvironment
promoting
activation.
Further
studies
demonstrate
effectively
kills
human
murine
cells,
inhibits
orthotopic
U87
growth
BALB/c‐nu
mice,
enhances
efficacy
Fn14‐targeted
BiTE
GL261
C57BL/6
achieving
synergistic
“1+1>2”
therapeutic
effect.
Collectively,
this
work
opens
new
pathway
using
Hcy‐based
molecules
combined
drugs
therapy,
significant
clinical
potential.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(47), P. 32582 - 32594
Published: Nov. 13, 2024
Near-infrared
II
(NIR-II)
phototheranostic
agents
have
become
prominent
for
the
early
diagnosis
and
precise
treatment
of
cancer.
Organic
open-shell
diradicaloids
with
distinct
structure
narrow
band
gap
are
promising
candidates
phototherapeutic
due
to
their
strong
spin-coupling
effect
NIR
light-harvesting
capacity.
However,
achieving
stable
efficient
NIR-II
luminescent
is
crucial
yet
rather
challenging
considering
high
chemical
reactivity
self-absorption.
Herein,
two
highly
diradicaloids,
2PhNVDPP
PhNVDPP,
were
successfully
fabricated
by
employing
an
acceptor
planarization/π-conjugation
extension
donor
rotation
strategy.
After
encapsulation
into
water-dispersible
nanoparticles
(NPs),
NPs
exhibit
luminescence,
PCE
53%,
improved
photo/heat
stability.
In
vivo
experiments
demonstrated
clear
visualization
blood
vessels
tumors,
as
well
successful
imaging-guided
photothermal
ablation
tumors.
This
study
not
only
develops
a
pioneering
diradicaloid
agent
luminescence
but
also
provides
unique
perspective
effectiveness
multimodal
anticancer
therapy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Abstract
Despite
recent
advancements
in
the
development
of
blood‐brain
barrier
(BBB)‐crossing
nanomaterials
for
intravenous
administration,
there
have
been
very
few
successful
cases
clinical
trials.
Ongoing
challenges
within
body
impede
precise
therapeutic
effects
these
from
reaching
their
intended
target
area.
Therefore,
a
comprehensive
analysis
entire
pathway
that
BBB‐crossing
must
traverse‐from
bloodstream
to
brain‐along
with
an
understanding
obstacles
encountered
along
way,
is
essential
advancing
materials
This
review
begins
brief
overview
structure
and
function
BBB,
as
well
pathways
strategies
crossing
it.
Next,
it
discussed
analyzed
common
sites
brain
bloodstream.
To
address
challenges,
“eight‐step”
guideline
strategy
proposed.
By
leveraging
principles
precision
medicine,
design
customization
cascade‐targeted
can
overcome
multiple
show
promise
future
trials
practical
applications.
Finally,
perspective
on
direction
this
field
offered.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(40), P. 5322 - 5325
Published: Jan. 1, 2024
An
NIR-II-emitting
type-I
photosensitizer
with
a
strong
push–pull
effect
and
good
planar
π-conjugated
structure
was
synthesized
for
efficient
hypoxic
tumor
phototheranostics.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(20), P. 10088 - 10103
Published: Oct. 8, 2024
Fluorescence
imaging
(FLI)
in
the
second
near-infrared
window
(NIR-II,
1000–1700
nm)
provides
great
promise
for
visualization
of
pathology
and
physiology
at
molecular
level,
with
high
spatial
resolution
deep
tissue
penetration.
Particularly,
increasing
studies
focus
on
creating
organic
semiconducting
chromophores
(OSCs)
noninvasive
NIR-IIb
(1500–1700
near-zero
autofluorescence
a
greatly
enhanced
This
review
aims
to
unravel
labyrinth
engineering
highly
bright
OSCs
advancing
imaging.
We
summarize
highlight
five
strategic
designs
boosting
fluorescence
emission,
containing
manipulation
intramolecular
motions,
an
atom-programming
strategy,
construction
polymer
dots,
J-aggregation
regulation
creation
molecule–protein
complexes.
Eventually,
potential
directions
improving
application
fluorophores
toward
clinical
practices
are
emphasized.
envision
that
this
will
provide
design
reference
high-performance
long-wavelength
fluorescent
emitters,
thereby
paving
way
future
FLI.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 9, 2024
The
contradiction
of
near-infrared
II
(NIR-II)
emission
and
photothermal
effects
limits
the
development
phototheranostic
agents
(PTAs)
in
many
emerging
cutting-edge
applications.
Organic
aggregates
present
a
promising
opportunity
for
balance
competitive
relaxation
processes
through
manipulation
molecular
structure
packing.
Herein,
side
chain
phenyl
isomerization-induced
spatial
conjugation
was
proposed
constructing
A-D-A
type
NIR-II
PTAs
with
simultaneous
enhancement
fluorescence
brightness
properties.
Three
pairs
mutually
isomeric
fluorophores,
whose
phenyls
respectively
located
at
outside
(o-series)
inside
(i-series)
chain,
were
designed
synthesized.
positional
isomerization
endows
o-series
crystals
strong
between
group
on
backbone,
as
well
interlocked
planar
network,
which
is
different
to
that
observed
i-series.
Thus,
all
nanoparticles
(NPs)
exhibit
red-shifted
absorption,
enhanced
emission,
superior
properties
than
their
i-series
counterparts.
A
prominent
member
o-series,
o-ITNP
NPs,
demonstrated
efficacy
facilitating
angiography,
tumor
localization,
imaging-guided
therapy.
success
this
strategy
paves
way
precise
control
aggregation
behavior
further
efficient
PTAs.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
J-aggregates
show
great
promise
in
phototherapy,
but
are
limited
to
specific
molecular
skeletons
and
poor
self-assembly
controllability.
Herein,
we
report
a
twisted-planar
strategy
with
sonication-induced
J-aggregation
develop
donor-acceptor
(D-A)
type
for
phototherapy.
With
propeller
aggregation-induced
emission
(AIE)
moieties
as
the
twisted
subunits
thiophene
planar
π-bridge,
optimal
π-interaction
MTSIC
induces
appropriate
slip
angle
formation,
redshifting
absorption
from
624
nm
790
nm.
In
contrast,
shorter
π-planarity
results
amorphous
aggregates,
elongation
promotes
charge
transfer
(CT)
coupled
J-aggregates.
Sonication
was
demonstrated
be
effective
controlling
behaviors
of
MTSIC,
which
enables
transformation
aggregates
H-intermediates,
finally
stable
After
encapsulation
lipid-PEG,
resultant
J-dots
enhanced
phototherapeutic
effects
over
dots,
including
brightness,
reactive
oxygen
species
(ROS)
generation,
photothermal
conversion,
delivering
superior
cancer
phototherapy
performance.
This
work
not
only
advances
D-A
design
also
provides
promising
supramolecular
assembly
development.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 9, 2024
Abstract
The
contradiction
of
near‐infrared
II
(NIR‐II)
emission
and
photothermal
effects
limits
the
development
phototheranostic
agents
(PTAs)
in
many
emerging
cutting‐edge
applications.
Organic
aggregates
present
a
promising
opportunity
for
balance
competitive
relaxation
processes
through
manipulation
molecular
structure
packing.
Herein,
side
chain
phenyl
isomerization‐induced
spatial
conjugation
was
proposed
constructing
A‐D‐A
type
NIR‐II
PTAs
with
simultaneous
enhancement
fluorescence
brightness
properties.
Three
pairs
mutually
isomeric
fluorophores,
whose
phenyls
respectively
located
at
outside
(
o
‐series)
inside
i
chain,
were
designed
synthesized.
positional
isomerization
endows
‐series
crystals
strong
between
group
on
backbone,
as
well
interlocked
planar
network,
which
is
different
to
that
observed
‐series.
Thus,
all
nanoparticles
(NPs)
exhibit
red‐shifted
absorption,
enhanced
emission,
superior
properties
than
their
counterparts.
A
prominent
member
‐series,
‐ITNP
NPs,
demonstrated
efficacy
facilitating
angiography,
tumor
localization,
imaging‐guided
therapy.
success
this
strategy
paves
way
precise
control
aggregation
behavior
further
efficient
PTAs.
