Nanoscale, Journal Year: 2023, Volume and Issue: 15(21), P. 9457 - 9476
Published: Jan. 1, 2023
We report the new biomimetic nanoparticles, which is synergistic combination of immunogenic cell death inducer and immunoadjuvant, proving to be unique strategy successfully induce an immune response boost anticancer response.
Language: Английский
Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 94 - 114
Published: Aug. 7, 2023
Immunogenic cell death (ICD) is a unique mode of death, which can release immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens to trigger long-term protective antitumor immune responses. Thus, amplifying "eat me signal" during tumor ICD cascade critical for cancer immunotherapy. Some therapies (radiotherapy, photodynamic therapy (PDT), photothermal (PTT), etc.) inducers (chemotherapeutic agents, have enabled initiate and/or facilitate activate Recently, nanostructure-based drug delivery systems been synthesized inducing through combining treatment chemotherapeutic photosensitizers PDT, transformation agents PTT, radiosensitizers radiotherapy, etc., loaded at an appropriate dosage in the designated place time, contributing higher efficiency lower toxicity. Also, immunotherapeutic combination with produce synergetic effects, thus potentiating Overall, our review outlines emerging inducers, nanostructure loading diverse evoke chemoradiotherapy, PTT or agents. Moreover, we discuss prospects challenges harnessing induction-based immunotherapy, highlight significance multidisciplinary interprofessional collaboration promote optimal translation this strategy.
Language: Английский
Citations
44
Materials Today, Journal Year: 2024, Volume and Issue: 73, P. 79 - 95
Published: Feb. 12, 2024
Language: Английский
Citations
25
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444
Published: Jan. 1, 2024
This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.
Language: Английский
Citations
24
ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10625 - 10641
Published: April 2, 2024
Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.
Language: Английский
Citations
18
Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101512 - 101512
Published: April 18, 2024
Our previous work developed acoustic response bacteria, which enable the precise tuning of transgene expression through ultrasound. However, it is still difficult to visualize these bacteria in order guide sound wave precisely irradiate them. Here, we develop ultrasound-visible engineered and chemically modify them with doxorubicin (DOX) on their surfaces. These (Ec@DIG-GVs) can produce gas vesicles (GVs), providing a real-time imaging for remote hyperthermia high-intensity focused ultrasound (hHIFU) induce interferon (IFN)-γ gene. The production IFN-γ kill tumor cells, macrophage polarization from M2 M1 phenotype, promote maturation dendritic cells. DOX be released acidic microenvironment, resulting immunogenic cell death concurrent effects activate tumor-specific T response, producing synergistic anti-tumor efficacy. study provides promising strategy bacteria-mediated chemo-immunotherapy.
Language: Английский
Citations
18
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.
Language: Английский
Citations
4
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 686, P. 498 - 508
Published: Jan. 31, 2025
Language: Английский
Citations
2
Small, Journal Year: 2023, Volume and Issue: 19(43)
Published: June 28, 2023
Innate immunity triggered by the cGAS/STING pathway has potential to improve cancer immunotherapy. Previously, authors reported that double-stranded DNA (dsDNA) released dying tumor cells can trigger pathway. However, owing efferocytosis, are engulfed and cleared before damaged dsDNA is released; hence, immunologic tolerance immune escape occur. Herein, a cancer-cell-membrane biomimetic nanocomposites exhibit tumor-immunotherapeutic effects synthesized augmenting suppressing efferocytosis. Once internalized cells, combined chemo/chemodynamic therapy would be triggered, which damages their nuclear mitochondrial DNA. Furthermore, releasing Annexin A5 protein could inhibit efferocytosis effect promote immunostimulatory secondary necrosis preventing phosphatidylserine exposure, resulting in burst release of dsDNA. These fragments, as molecular patterns immunogenic damage, from activate pathway, enhance cross-presentation inside dendritic M1-polarization tumor-associated macrophages. In vivo experiments suggest proposed nanocomposite recruit cytotoxic T-cells facilitate long-term immunological memory. Moreover, when with immune-checkpoint blockades, it augment response. Therefore, this novel promising strategy for generating adaptive antitumor responses.
Language: Английский
Citations
31
Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)
Published: June 23, 2023
Developing a multifunctional nanoplatform to achieve efficient theranostics of tumors through multi-pronged strategies remains be challenging. Here, the design intelligent redox-responsive generation 3 (G3) poly(amidoamine) dendrimer nanogels (NGs) loaded with gold nanoparticles (Au NPs) and chemotherapeutic drug toyocamycin (Au/Toy@G3 NGs) for ultrasound-enhanced cancer is showcased. The constructed hybrid NGs size 193 nm possess good colloidal stability under physiological conditions, can dissociated release Au NPs Toy in reductive glutathione-rich tumor microenvironment (TME). released promote apoptosis cells endoplasmic reticulum stress amplification cause immunogenic cell death maturate dendritic cells. induce conversion tumor-associated macrophages from M2-type antitumor M1-type remodulate immunosuppressive TME. Combined antibody-mediated immune checkpoint blockade, effective chemoimmunotherapy pancreatic mouse model realized, effect further ultrasound enhanced due sonoporation-improved permeability NGs. developed Au/Toy@G3 also enable Au-mediated computed tomography imaging tumors. responsive dendrimeric tackle strategy targeting both cells, which hold promising potential clinical translations.
Language: Английский
Citations
29
ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2195 - 2209
Published: Jan. 9, 2024
Nanocarrier-based cytoplasmic protein delivery offers opportunities to develop therapeutics; however, many systems are positively charged, causing severe toxic effects. For enhanced therapeutics, it is also of great importance design nanocarriers with intrinsic bioactivity that can be integrated drugs due the limited proteins alone for disease treatment. We report here a system based on anionic phosphite-terminated phosphorus dendrimers anti-inflammatory activity. A dendrimer termed AK-137 optimized activity was selected complex through various physical interactions. Model such as bovine serum albumin, ribonuclease A, ovalbumin, and fibronectin (FN) transfected into cells exert their respective functions, including cancer cell apoptosis, dendritic maturation, or macrophage immunomodulation. Particularly, constructed AK-137@FN nanocomplexes display powerful therapeutic effects in acute lung injury gout arthritis models by integrating both carrier protein. The developed may employed universal particularly utilized deliver fight different inflammatory diseases efficacy.
Language: Английский
Citations
16