Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
The application of nanotechnology in medical biology has seen a significant rise recent years because the introduction novel tools that include supramolecular systems, complexes, and composites.
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 686, P. 498 - 508
Published: Jan. 31, 2025
Language: Английский
Citations
3
ACS Nano, Journal Year: 2024, Volume and Issue: 18(14), P. 10142 - 10155
Published: March 25, 2024
Fully mobilizing the activities of multiple immune cells is crucial to achieve desired tumor immunotherapeutic efficacy yet still remains challenging. Herein, we report a nanomedicine formulation based on phosphorus dendrimer (termed AK128)/programmed cell death protein 1 antibody (aPD1) nanocomplexes (NCs) that are camouflaged with M1-type macrophage membranes (M1m) for enhanced immunotherapy orthotopic glioma. The constructed AK128-aPD1@M1m NCs mean particle size 160.3 nm possess good stability and cytocompatibility. By virtue decorated M1m having α4 β1 integrins, able penetrate blood-brain barrier codeliver both AK128 intrinsic immunomodulatory activity aPD1 glioma prolonged blood circulation time. We show can boost natural killer (NK) proliferation in peripheral mononuclear cells, while delivered enables checkpoint blockade (ICB) restore cytotoxic T NK thus promoting apoptosis simultaneously decreasing distribution regulatory vastly improved immunotherapy. developed simple composition achieves modulations by utilizing nanocarrier antibody-mediated ICB therapy, providing an effective strategy cancer
Language: Английский
Citations
17
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113869 - 113869
Published: March 21, 2024
Language: Английский
Citations
13
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: June 18, 2024
Abstract Acute lung injury ( ALI ) is a common complication in patients with severe burns and has complex pathogenesis high morbidity mortality rates. A variety of drugs have been identified the clinic for treatment ALI, but they toxic side effects caused by easy degradation body distribution throughout body. In recent years, as understanding mechanism underlying improved, scholars developed new nanomaterials that can be safely effectively targeted ALI. Most these methods involve such lipids, organic polymers, peptides, extracellular vesicles or cell membranes, inorganic nanoparticles other nanomaterials, which are to reach tissues perform their functions through active targeting passive targeting, process involves cells organelles. this review, first, mechanisms pathophysiological features occurrence after burn reviewed, potential therapeutic targets summarized, existing classified, possible problems challenges discussed provide reference development
Language: Английский
Citations
11
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Language: Английский
Citations
2
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 45 - 54
Published: April 23, 2024
Effective treatment of Parkinson's disease (PD), a prevalent central neurodegenerative disorder particularly affecting the elderly population, still remains huge challenge. We present here novel nanomedicine formulation based on bioactive hydroxyl-terminated phosphorous dendrimers (termed as AK123) complexed with fibronectin (FN) anti-inflammatory and antioxidative activities. The created optimized AK123/FN nanocomplexes (NCs) size 223 nm display good colloidal stability in aqueous solution can be specifically taken up by microglia through FN-mediated targeting. show that NCs are able to consume excessive reactive oxygen species, promote M2 polarization inhibit nuclear factor-kappa B signaling pathway downregulate inflammatory factors. With abundant dendrimer surface hydroxyl terminal groups, developed cross blood-brain barrier (BBB) exert targeted therapy PD mouse model AK123-mediated anti-inflammation for antioxidant effects, thus reducing aggregation α-synuclein restoring contents dopamine tyrosine hydroxylase normal levels vivo. dendrimer/FN combine advantages BBB-crossing per se phosphorus FN, which is expected extended different diseases.
Language: Английский
Citations
9
Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 122999 - 122999
Published: Dec. 5, 2024
Language: Английский
Citations
7
Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102664 - 102664
Published: Feb. 12, 2025
Language: Английский
Citations
1
Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116365 - 116365
Published: April 1, 2025
Language: Английский
Citations
1
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(10), P. 11022 - 11036
Published: May 7, 2024
Phosphorus is widely present in living organisms and nature exists a variety of isomers with variable crystal structures. There are several common phosphorus monomers biomedicine, including red (RP), black (BLK-P), violet (VP), blue (BLU-P). Phosphorus-based semiconductor materials (PSCM) have adjustable band gaps, high photogenerated carrier mobility, efficient photothermal conversion as well good biocompatibility degradability. In addition, phosphorus, an essential element for life-sustaining activities, all cells the human body, accounting approximately 1% body's total weight. Therefore, phosphorus-based nanomaterials extensive applications biomedical field. This review will clarify classification, preparation methods, physicochemical properties, mechanisms action, biomedicine while also offering new ideas their development biomedicine.
Language: Английский
Citations
6