Communications Materials,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: June 12, 2024
Abstract
Overcoming
the
mechanical
disparities
between
implantable
neural
electrodes
and
biological
tissue
is
crucial
in
mitigating
immune
responses,
reducing
shear
motion,
ensuring
durable
functionality.
Emerging
hydrogel-based
interfaces,
with
their
volumetric
capacitance,
customizable
conductivity,
tissue-mimicking
properties,
offer
a
more
efficient,
less
detrimental,
chronically
stable
alternative
to
rigid
counterparts.
Here,
we
provide
an
overview
of
exceptional
advantages
hydrogels
for
development
next-generation
interfaces
highlight
recent
advancements
that
are
transforming
field.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Neural
biointerfacing,
enabling
direct
communication
between
neural
systems
and
external
devices,
holds
great
promises
for
applications
in
brain
machine
interfaces,
prosthetics,
neuromodulation.
However,
current
electronics
made
of
conventional
rigid
materials
are
challenged
by
their
inherent
mechanical
mismatch
with
the
tissues.
Hydrogel
bioelectronics,
properties
compatible
tissues,
represent
an
alternative
to
these
limitations
enable
next‐generation
biointerfacing
technology.
Here,
overview
cutting‐edge
research
on
conducting
hydrogels
(CHs)
bioelectronics
development,
emphasizing
material
design
principles,
manufacturing
techniques,
essential
requirements,
corresponding
application
scenarios
is
presented.
Future
challenges
potential
directions
regarding
CHs‐based
technologies,
including
long‐term
reliability,
multimodal
hydrogel
closed‐loop
system
wireless
power
supply
system,
raised.
It
believed
that
this
review
will
serve
as
a
valuable
resource
further
advancement
implementation
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Achieving
high-quality
biopotential
signal
recordings
requires
soft
and
stable
interfaces
between
tissues
bioelectronic
devices.
Traditional
bioelectronics,
typically
rigid
dependent
on
medical
tape
or
sutures,
lead
to
mechanical
mismatches
inflammatory
responses.
Existing
conducting
polymer-based
bioelectronics
offer
tissue-like
softness
but
lack
intrinsic
adhesion,
limiting
their
effectiveness
in
creating
stable,
conductive
interfaces.
Here,
we
present
an
intrinsically
adhesive
hydrogel
with
a
modulus
strong
adhesion
various
substrates.
Adhesive
catechol
groups
are
incorporated
into
the
poly(3,4-ethylenedioxythiophene)
(PEDOT)
matrix,
which
reduces
PEDOT
size
improves
dispersity
form
percolating
network
excellent
electrical
conductivity
strain
insensitivity.
This
effectively
bridges
bioelectronics–tissue
interface,
ensuring
pristine
minimal
interference
from
bodily
movements.
capability
is
demonstrated
through
comprehensive
vivo
experiments,
including
electromyography
electrocardiography
both
static
dynamic
human
skin
electrocorticography
moving
rats.
represents
significant
advancement
for
interfaces,
facilitating
more
accurate
less
intrusive
diagnostics.
MRS Bulletin,
Journal Year:
2023,
Volume and Issue:
48(5), P. 495 - 505
Published: May 1, 2023
Abstract
Hydrogels
are
a
class
of
soft
materials,
which
display
unique
biomimetic
properties
to
biological
tissues.
Their
mechanical
properties,
high
water
content,
and
porosity
resemble
that
extracellular
matrix
so
cell
growth
proliferation
can
be
reliably
supported.
In
vitro
studies
report
mechanosensitive
cells
found
in
the
central
nervous
system,
such
as
astrocytes
glia,
reduced
activation,
thus
promoting
lower
foreign
body
reaction,
when
cultured
on
hydrogel
substrates
<1-kPa
modulus.
This
observation
provides
an
opportunity
explore
whether
hydrogels
should
integrated
or
form
implantable
neural
interfaces
offer
long-term
biointegrated
neurotechnologies.
article
highlights
recent
progress
materials
associated
technologies
for
design
bioelectronics.
Essential
structural,
mechanical,
electronical
composite
briefly
reviewed.
Manufacturing
methods
suitable
these
multiscale
multifunctional
presented.
The
final
section
presents
hydrogel-based
bioelectronics
brain
outlines
current
challenges
future
opportunities.
Graphical
abstract
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(16)
Published: Feb. 25, 2024
Abstract
The
foreign
body
response
(FBR)
to
implanted
biomaterials
and
biomedical
devices
can
severely
impede
their
functionality
even
lead
failure.
discovery
of
effective
anti‐FBR
materials
remains
a
formidable
challenge.
Inspire
by
the
enrichment
glutamic
acid
(E)
lysine
(K)
residues
on
human
protein
surfaces,
class
zwitterionic
polypeptide
(ZIP)
hydrogels
with
alternating
E
K
sequences
mitigate
FBR
is
prepared.
When
subcutaneously
implanted,
ZIP
caused
minimal
inflammation
after
2
weeks
no
obvious
collagen
capsulation
6
months
in
mice.
Importantly,
these
effectively
resisted
non‐human
primate
models
for
at
least
months.
In
addition,
enzymatic
degradability
gel
be
controlled
adjusting
crosslinking
degree
or
optical
isomerism
amino
monomers.
long‐term
resistance
open
up
new
possibilities
broad
range
applications.
Journal of Materials Chemistry A,
Journal Year:
2024,
Volume and Issue:
12(32), P. 20606 - 20637
Published: Jan. 1, 2024
This
paper
reviews
the
progress
of
flexible
electrodes
in
recent
years,
including
substrates,
active
materials,
manufacturing
methods,
and
their
latest
applications
sensors,
energy
storage,
medical
healthcare.
Small,
Journal Year:
2024,
Volume and Issue:
20(43)
Published: June 29, 2024
Conductive
flexible
hydrogels
have
attracted
immense
attentions
recently
due
to
their
wide
applications
in
wearable
sensors.
However,
the
poor
mechanical
properties
of
most
conductive
polymer
limit
utilizations.
Herein,
a
double
network
hydrogel
is
fabricated
via
self-sorting
process
with
cationic
polyacrylamide
as
first
and
lantern[3
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Abstract
Bioelectronic
patches
hold
promise
for
patient‐comfort
wound
healing
providing
simplified
clinical
operation.
Currently,
they
face
paramount
challenges
in
establishing
long‐term
effective
electronic
interfaces
with
targeted
cells
and
tissues
due
to
the
inconsistent
energy
output
high
bio
interface
impedance.
Here
a
new
electrochemical
stimulation
technology
is
reported,
using
simple
patch,
which
integrates
efficient
generation
delivery
of
stimulation.
This
realized
by
employing
hydrogel
bioelectronic
as
an
active
component
integrated
power
source
(i.e.,
Mg
battery).
The
battery
enhances
fibroblast
functions
(proliferation,
migration,
growth
factor
secretion)
regulates
macrophage
phenotype
(promoting
regenerative
polarization
down‐regulating
pro‐inflammatory
cytokines),
electric
field
ability
control
cellular
microenvironment
through
chemical
release.
patch
shows
accelerated
closure
guiding
epithelial
mediating
immune
response,
promoting
vasculogenesis.
electrochemical‐mediated
therapy
may
provide
avenue
user‐friendly
management
well
platform
fundamental
insights
into
cell
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Hydrogels
are
emerging
as
promising
candidates
for
brain–computer
interfaces.
This
review
highlights
the
current
advancements
in
implantable
hydrogel
electrodes
neural
signal
recording,
neuromodulation,
and
brain
disorder
treatment.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Abstract
Driven
by
the
growing
burden
of
chronic
diseases
and
limited
public
healthcare
resources,
portable
health
monitoring
platforms
are
widely
developed
to
enable
continuous
timely
dissemination
provide
users
with
management
disease
prevention.
However,
it
is
still
a
challenge
for
precision
fully
bio‐integrated
electronic
devices
achieve
stable
physiological
signal
recording
over
long
periods
time.
Recently,
semi‐implantable
bioelectronics
(SI‐bioelectronics)
have
excelled
in
real‐time,
long‐term,
high‐sensitivity
pathological
signals
minimal
invasiveness,
enabled
precise
microneedle
sensing
probes.
In
this
review,
comprehensive
overview
recent
advancements
SI‐bioelectronics
provided,
focus
on
their
structures,
design
considerations,
performances
biochemical
indicators,
bioelectrical
signals,
biomechanical
signals.
Opportunities
research
such
as
smart
medicine
Internet
Things
also
discussed,
which
will
drive
toward
intelligence
efficiency.
