Advances in brain computer interface for amyotrophic lateral sclerosis communication DOI Creative Commons
Yuchun Wang, Yuee Tang, Qianfeng Wang

et al.

Brain‐X, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 1, 2025

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that often results in the loss of speech, creating significant communication barriers. Brain–computer interfaces (BCIs) provide transformative solution for restoring and enhancing quality life ALS individuals. Recent advances implantable electrocorticographic systems have demonstrated feasibility synthesizing intelligible speech directly from neural activity. By recording high‐resolution signals motor, premotor, somatosensory cortices with decoding algorithms, these can transform patterns into acoustic features providing natural intuitive pathways Non‐invasive electroencephalography, while lacking spatial resolution systems, offers safer alternative high temporal capturing speech‐related dynamics. When combined robust feature extraction techniques, such as common pattern time‐frequency analyses, well multimodal integration functional near‐infrared spectroscopy or electromyography, it effectively enhances accuracy system robustness. Despite progress, challenges remain, including user variability, BCI illiteracy, impact fatigue on performance. Personalized models, adaptive secure frameworks brain data privacy are essential addressing limitations, enabling BCIs to enhance accessibility reliability. Advancing technologies methodologies holds immense promise independence bridging gap individuals ALS. Future research could focus long‐term clinical studies evaluate stability effectiveness development more unobtrusive paradigms.

Language: Английский

Flexible Conformally Bioadhesive MXene Hydrogel Electronics for Machine Learning‐Facilitated Human‐Interactive Sensing DOI
Wei Wang,

Hailiang Zhou,

Zhishan Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: March 29, 2024

Wearable epidermic electronics assembled from conductive hydrogels are attracting various research attention for their seamless integration with human body conformally real-time health monitoring, clinical diagnostics and medical treatment, human-interactive sensing. Nevertheless, it remains a tremendous challenge to simultaneously achieve bioadhesive remarkable self-adhesiveness, reliable ultraviolet (UV) protection ability, admirable sensing performance high-fidelity epidermal electrophysiological signals along timely photothermal therapeutic performances after diagnostic sensing, as well efficient antibacterial activity hemostatic effect potential therapy. Herein, hydrogel-based sensor, featuring superior self-adhesiveness excellent UV-protection performance, is developed by dexterously assembling conducting MXene nanosheets network biological hydrogel polymer stably attaching onto skin high-quality recording of high signal-to-noise ratios (SNR) low interfacial impedance intelligent diagnosis smart human-machine interface. Moreover, sign language gesture recognition platform based on collected electromyogram (EMG) designed hassle-free communication hearing-impaired people the help advanced machine learning algorithms. Meanwhile, possesses capability, biocompatibility, effective hemostasis properties promising bacterial-infected wound bleeding.

Language: Английский

Citations

68
Neural interfaces: Bridging the brain to the world beyond healthcare DOI Creative Commons
Shumao Xu,

Yang Liu,

Hyun‐Jin Lee

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 14, 2024

Abstract Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings communicate. By recording decoding neural signals, these interfaces facilitate direct connections between brain external devices, enabling seamless information exchange shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, algorithmic design. Electrophysiological crosstalk mismatch electrode rigidity tissue flexibility further complicate signal fidelity biocompatibility. Recent closed‐loop brain‐computer while promising for mood regulation cognitive enhancement, are limited accuracy adaptability user interfaces. This perspective outlines challenges discusses progress contrasting non‐invasive invasive approaches, explores dynamics stimulation interfacing. Emphasis placed on applications beyond healthcare, highlighting need implantable high‐resolution capabilities.

Language: Английский

Citations

22
Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

22
Conducting Hydrogel‐Based Neural Biointerfacing Technologies DOI Open Access
Pei Zhang, Yifan Yang,

Zhaobo Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Language: Английский

Citations

2
Implantable Soft Neural Electrodes of Liquid Metals for Deep Brain Stimulation DOI
Yong Won Kwon, Enji Kim, Chin Su Koh

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Stimulating large volumes of neural networks using macroelectrodes can modulate disorder-associated brain circuits effectively. However, conventional solid-metal electrodes often cause unwanted damage due to their high mechanical stiffness. In contrast, low-modulus liquid metals provide tissue-like stiffness while maintaining macroscale electrode dimensions. Here, we present implantable soft made from biocompatible for stimulation. These probes be easily fabricated by simply filling polymeric tubes with a metal, offering straightforward method creating stimulation devices. They customized in various lengths and diameters also serve as recording microelectrodes. The tips are enhanced platinum nanoclusters, resulting low impedance effective charge injection preventing metal leakage into tissue. vivo experiments neuropathic pain rat models demonstrate the stability effectiveness these simultaneous recording, demonstrating potential alleviation behavioral control.

Language: Английский

Citations

2
Recent advances in flexible noninvasive electrodes for surface electromyography acquisition DOI Creative Commons
Lian Cheng, Jun Li, Aiying Guo

et al.

npj Flexible Electronics, Journal Year: 2023, Volume and Issue: 7(1)

Published: Aug. 16, 2023

Abstract Surface electromyography (sEMG) is used to detect and analyze human muscle biopotential. Recently, flexible noninvasive electrodes (FNEs) have emerged extract bioelectrical signals from individual bodies. For FNEs be deployed as a central component of physiological signal acquisition, the quest for elevated signal-to-noise ratio density compelling owing small amplitude sEMG. Herein, we review recent progress in sEMG acquisition. We summarize needed properties FNEs, compare differences between passive active exemplify applications FNEs. also conclude current challenges future opportunities

Language: Английский

Citations

39
Unlocking the biological response of smart Stimuli-Responsive hydrogels and their application in biological systems DOI
Moses Kumi, Onome Ejeromedoghene,

Wellington Dana Sudane

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 209, P. 112906 - 112906

Published: March 6, 2024

Language: Английский

Citations

14
Exploring the Potentials of Chitin and Chitosan‐Based Bioinks for 3D‐Printing of Flexible Electronics: The Future of Sustainable Bioelectronics DOI
Moses Kumi, Tengjiao Wang, Onome Ejeromedoghene

et al.

Small Methods, Journal Year: 2024, Volume and Issue: 8(9)

Published: Feb. 25, 2024

Chitin and chitosan-based bioink for 3D-printed flexible electronics have tremendous potential innovation in healthcare, agriculture, the environment, industry. This biomaterial is suitable 3D printing because it highly stretchable, super-flexible, affordable, ultrathin, lightweight. Owing to its ease of use, on-demand manufacturing, accurate regulated deposition, versatility with soft functional materials, has revolutionized free-form construction end-user customization. study examined employing chitin bioinks build electronic devices optimize formulation, parameters, postprocessing processes improve mechanical electrical properties. The exploration bioelectronics will open new avenues materials numerous industrial applications.

Language: Английский

Citations

9
Application and Development of EEG Acquisition and Feedback Technology: A Review DOI Creative Commons
Yong Qin, Yanpeng Zhang, Zhang Yan

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(10), P. 930 - 930

Published: Oct. 17, 2023

This review focuses on electroencephalogram (EEG) acquisition and feedback technology its core elements, including the composition principles of devices, a wide range applications, commonly used EEG signal classification algorithms. First, we describe construction devices encompassing electrodes, processing, control systems, which collaborate to measure faint signals from scalp, convert them into interpretable data, accomplish practical applications using systems. Subsequently, examine diverse across various domains. In medical field, are employed for epilepsy diagnosis, brain injury monitoring, sleep disorder research. has revealed associations between functionality, cognition, emotions, providing essential insights psychologists neuroscientists. Brain-computer interface utilizes human-computer interaction, driving innovation in medical, engineering, rehabilitation Finally, introduce These tasks can identify different cognitive states, emotional disorders, brain-computer promote further development application technology. conclusion, deepen understanding while simultaneously promoting developments multiple domains, such as medicine, science, engineering.

Language: Английский

Citations

14
Implantable Neural Microelectrodes: How to Reduce Immune Response DOI

Ying Xiang,

Yuewu Zhao,

Tingting Cheng

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(5), P. 2762 - 2783

Published: April 9, 2024

Implantable neural microelectrodes exhibit the great ability to accurately capture electrophysiological signals from individual neurons with exceptional submillisecond precision, holding tremendous potential for advancing brain science research, as well offering promising avenues neurological disease therapy. Although significant advancements have been made in channel and density of implantable microelectrodes, challenges persist extending stable recording duration these microelectrodes. The enduring stability implanted electrode is primarily influenced by chronic immune response triggered slight movement within tissue. intensity this increases a higher bending stiffness electrode. This Review thoroughly analyzes sequential reactions evoked electrodes highlights strategies aimed at mitigating responses. Minimizing mainly includes designing microelectrode structure, selecting flexible materials, surface modification, controlling drug release. purpose paper provide valuable references ideas reducing stimulate their further exploration field science.

Language: Английский

Citations

5