Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 17, 2025
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract The global crisis of bacterial infections is exacerbated by the escalating threat microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for treatment infected wounds. Catalytic site normalization showed that active aggregates fine‐tuned pore modifications had capacity 14.903×10 5 min −1 , which was 18.7 times higher than particles in monodisperse state ZIF‐8 (0.793×10 ). In situ tests revealed change from homocleavage heterocleavage hydrogen peroxide at interface nanozyme one key reasons improvement activity. Density‐functional theory and kinetic simulations reaction jointly determine role center substrate together. Metabolomics analysis developed nanozyme, working conjunction reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading spontaneous apoptosis rupture. This pioneering study elucidates new ideas regulation artificial enzyme activity provides perspectives development efficient substitutes.
Language: Английский
Citations
40
Nano Letters, Journal Year: 2024, Volume and Issue: 24(37), P. 11697 - 11705
Published: Sept. 3, 2024
Osteoarthritis (OA) is a degenerative joint disease characterized by obscure etiology and unsatisfactory therapeutic outcomes, making the development of new efficient therapies urgent. Superfluous reactive oxygen species (ROS) have historically been considered one crucial factors inducing pathological progression OA. Ultrasmall Prussian blue nanoparticles (USPBNPs), approximately sub-5 nm in size, are developed regulating configuration polyvinylpyrrolidone chains. USPBNPs display an excellent ROS eliminating capacity catalase-like activity, capable decomposing hydrogen peroxide (H
Language: Английский
Citations
10
Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104292 - 104292
Published: Jan. 1, 2025
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract Remodeling of the tumor immune microenvironment and enhancement antitumor responses are necessary to overcome immunotherapy resistance in tumors. However, heterogeneity complexity evasion mechanisms pose significant therapeutic challenges. Nanozymes exhibit enzyme‐like characteristics unique nanomaterial properties, showing potential for therapy. design effective nanozymes remains complex, inefficient, functionally limited. Therefore, this study, a novel strategy combining rationally designed single‐atom (SAzymes) with checkpoint blockade (ICB) therapy is established. Molybdenum SAzymes supported on graphitic carbon nitride (Mo SAs) constructed using 25 transition metal candidates from 4th 6th periods based high‐throughput calculations optimal piezoelectric‐enhanced multienzyme‐like activities. Upon activation by ultrasound, Mo SAs exerted potent effects against ICB‐resistant tumors remodeled inducing immunogenic cell death, alleviating hypoxia, modulating chemokine expression Combination anti‐programmed death protein‐1 antibodies further enhanced their efficacy, highlighting treat
Language: Английский
Citations
2
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 12, 2024
In contrast to homogeneous enzyme catalysis, nanozymes are nanosized heterogeneous catalysts that perform reactions on a rigid surface. This fundamental difference between enzymes and is often overlooked in kinetic studies practical applications. this article, using 14 of various compositions (core@shell, metal-organic frameworks, metal, metal oxide nanoparticles), we systematically demonstrate nontypical features nanozymes, such as multiple catalytic activities, chemical transformations, aggregation, need be considered nanozyme catalysis. Ignoring these results the inaccurate quantification activity. Neglecting activities led six-time underestimation Mn
Language: Английский
Citations
9
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 24, 2024
Abstract Oxidative stress and inflammation are at the root of a multitude diseases. Treatment these conditions is often necessary but current standard therapies to fight excessive reactive oxygen species (ROS) ineffective or complicated by substantial safety concerns. Nanozymes emerging nanomaterials with intrinsic enzyme‐like properties that hold great promise for effective cancer treatment, bacterial elimination, anti‐inflammatory/anti‐oxidant therapy. While there rapid progress in tailoring their catalytic activities as evidenced recent integration single‐atom catalysts (SACs) create next‐generation nanozymes superior activity, selectivity, stability, better understanding tuning profile imperative successful clinical translation. This review outlines applied assessment approaches provides comprehensive summary knowledge therapeutic nanozymes. Overall, so far show good vitro vivo biocompatibility despite considerable differences composition enzymatic activities. However, investigations mostly cover limited set basic toxicological endpoints, which do not allow thorough deep assessment. Ultimately, remaining research gaps should be carefully addressed future studies highlighted, optimize early pre‐clinical development.
Language: Английский
Citations
8
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)
Published: Aug. 16, 2024
Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.
Language: Английский
Citations
7
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112640 - 112640
Published: Jan. 1, 2025
Language: Английский
Citations
1
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112711 - 112711
Published: Jan. 1, 2025
Language: Английский
Citations
1