Programmed micro-nano hierarchical microspheres for the regulation of gut immunity DOI

Xiangyu Wei,

Peipei Xi,

Mei Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159446 - 159446

Published: Jan. 9, 2025

Language: Английский

Tailored Metal‐Organic Framework‐Based Nanozymes for Enhanced Enzyme‐Like Catalysis DOI Open Access
Zhichao Yu,

Zhenjin Xu,

Ruijin Zeng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract The global crisis of bacterial infections is exacerbated by the escalating threat microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for treatment infected wounds. Catalytic site normalization showed that active aggregates fine‐tuned pore modifications had capacity 14.903×10 5 min −1 , which was 18.7 times higher than particles in monodisperse state ZIF‐8 (0.793×10 ). In situ tests revealed change from homocleavage heterocleavage hydrogen peroxide at interface nanozyme one key reasons improvement activity. Density‐functional theory and kinetic simulations reaction jointly determine role center substrate together. Metabolomics analysis developed nanozyme, working conjunction reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading spontaneous apoptosis rupture. This pioneering study elucidates new ideas regulation artificial enzyme activity provides perspectives development efficient substitutes.

Language: Английский

Citations

38

Ultrasmall Prussian Blue Nanozyme Attenuates Osteoarthritis by Scavenging Reactive Oxygen Species and Regulating Macrophage Phenotype DOI
Zhiguo Qin, Xiaofei Li, Peng Wang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(37), P. 11697 - 11705

Published: Sept. 3, 2024

Osteoarthritis (OA) is a degenerative joint disease characterized by obscure etiology and unsatisfactory therapeutic outcomes, making the development of new efficient therapies urgent. Superfluous reactive oxygen species (ROS) have historically been considered one crucial factors inducing pathological progression OA. Ultrasmall Prussian blue nanoparticles (USPBNPs), approximately sub-5 nm in size, are developed regulating configuration polyvinylpyrrolidone chains. USPBNPs display an excellent ROS eliminating capacity catalase-like activity, capable decomposing hydrogen peroxide (H

Language: Английский

Citations

10

Nanozyme-based synergistic therapeutic strategies against tumors DOI
Ye Zhang, Ning Zhang, Shouping Gong

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104292 - 104292

Published: Jan. 1, 2025

Language: Английский

Citations

2

Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment DOI
Gang Xiao, Jiabin Zhang, Tong Lin

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Language: Английский

Citations

2

A spatial confinement biological heterogeneous cascade nanozyme composite hydrogel combined with nitric oxide gas therapy for enhanced treatment of psoriasis and diabetic wound DOI
Yuying Zhang, Cunpeng Nie, Zishu Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160629 - 160629

Published: Feb. 1, 2025

Language: Английский

Citations

1

A trifunctional surface ligand-directed general synthesis of 2D MOF hybrid nanozymes for customizable applications DOI
Wenyu Yang,

Ming‐Bo Yang,

Lingzhi Li

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 691, P. 137453 - 137453

Published: March 28, 2025

Language: Английский

Citations

1

Enzyme-inspired nanosensing of food antioxidants: From targeted quantification to system-level analysis DOI
Lunjie Huang, Xinyuan Zhao, Jianlong Wang

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105004 - 105004

Published: April 1, 2025

Language: Английский

Citations

1

Safety Landscape of Therapeutic Nanozymes and Future Research Directions DOI Creative Commons

Nikolaos Tagaras,

Haihan Song,

Shafaq Sahar

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Oxidative stress and inflammation are at the root of a multitude diseases. Treatment these conditions is often necessary but current standard therapies to fight excessive reactive oxygen species (ROS) ineffective or complicated by substantial safety concerns. Nanozymes emerging nanomaterials with intrinsic enzyme‐like properties that hold great promise for effective cancer treatment, bacterial elimination, anti‐inflammatory/anti‐oxidant therapy. While there rapid progress in tailoring their catalytic activities as evidenced recent integration single‐atom catalysts (SACs) create next‐generation nanozymes superior activity, selectivity, stability, better understanding tuning profile imperative successful clinical translation. This review outlines applied assessment approaches provides comprehensive summary knowledge therapeutic nanozymes. Overall, so far show good vitro vivo biocompatibility despite considerable differences composition enzymatic activities. However, investigations mostly cover limited set basic toxicological endpoints, which do not allow thorough deep assessment. Ultimately, remaining research gaps should be carefully addressed future studies highlighted, optimize early pre‐clinical development.

Language: Английский

Citations

8

Kinetic Profiling of Oxidoreductase-Mimicking Nanozymes: Impact of Multiple Activities, Chemical Transformations, and Colloidal Stability DOI
Vasily G. Panferov,

Wenjun Zhang,

Nicholas D’Abruzzo

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

In contrast to homogeneous enzyme catalysis, nanozymes are nanosized heterogeneous catalysts that perform reactions on a rigid surface. This fundamental difference between enzymes and is often overlooked in kinetic studies practical applications. this article, using 14 of various compositions (core@shell, metal-organic frameworks, metal, metal oxide nanoparticles), we systematically demonstrate nontypical features nanozymes, such as multiple catalytic activities, chemical transformations, aggregation, need be considered nanozyme catalysis. Ignoring these results the inaccurate quantification activity. Neglecting activities led six-time underestimation Mn

Language: Английский

Citations

8

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications DOI
Bin Zhang, Jiawei Zhu, Jinsong Ren

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)

Published: Aug. 16, 2024

Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.

Language: Английский

Citations

7