Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Hydrogels are emerging as promising candidates for brain–computer interfaces. This review highlights the current advancements in implantable hydrogel electrodes neural signal recording, neuromodulation, and brain disorder treatment.
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(39)
Published: June 24, 2023
The development of stable and biocompatible soft ionic conductors, alternatives to hydrogels ionogels, will open up new avenues for the construction stretchable electronics. Here, a brand-new design, encapsulating naturally occurring ionizable compound by polymer via high-density hydrogen bonds, resulting in solvent-free supramolecular ion-conductive elastomer (SF-supra-ICE) that eliminates dehydration problem possesses excellent biocompatibility, is reported. SF-supra-ICE with high conductivity (>3.3 × 10-2 S m-1 ) exhibits skin-like softness strain-stiffening behaviors, elasticity, breathability, self-adhesiveness. Importantly, can be obtained simple water evaporation step solidify aqueous precursor into nature. Therefore, act as inks painted printed customized tattoos (I-tattoos) multifunctional on-skin bioelectronics. I-tattoos exhibit ultraconformal seamless contact human skin, enabling long-term high-fidelity recording various electrophysiological signals extraordinary immunity motion artifacts. Human-machine interactions are achieved exploiting transmit beings. Stretchable I-tattoo electrode arrays, manufactured printing method, demonstrated multichannel digital diagnosis health condition back muscles spine.
Language: Английский
Citations
65
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)
Published: Jan. 4, 2024
Abstract Hydrogels are made tough to resist crack propagation. However, for seamless integration into devices and machines, it necessitates robustness against cyclic loads. Central this objective is enhancing fatigue resistance, an indispensable attribute facilitating the optimal performance of hydrogels within a multitude biological contexts, spanning various plant animal tissues, as well diverse biomedical engineering areas. In review, recent research concerning behavior hydrogels, presenting comprehensive consolidation inherent mechanisms that underpin strategies aimed at fortifying summarized. A critical facet in architectural blueprint fatigue‐resistant emphasized, involving imposition spatial constraints upon main chains tips, thereby effectuating protracted delay their fracture initiation during prolonged loading. The multiscale encompassing networks, interactions, media, structures stands pivotal factor design hydrogels. It hoped review will considerably propel pragmatic deployment across array applications, thus catalyzing advancements multiple fields.
Language: Английский
Citations
36
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: May 22, 2024
The past few decades have witnessed the rapid advancement and broad applications of flexible bioelectronics, in wearable implantable electronics, brain-computer interfaces, neural science technology, clinical diagnosis, treatment, etc. It is noteworthy that soft elastic conductive hydrogels, owing to their multiple similarities with biological tissues terms mechanics, water-rich, functions, successfully bridged gap between rigid electronics biology. Multifunctional hydrogel emerging as a new generation promising material candidates, authentically established highly compatible reliable, high-quality bioelectronic particularly recording stimulation. This review summarizes basis design principles involved constructing systematically discusses fundamental mechanism unique advantages bioelectrical interfacing surface. Furthermore, an overview state-of-the-art manufacturing strategies for interfaces enhanced biocompatibility integration system presented. finally exemplifies unprecedented impetus toward stimulation, especially integrated systems, concludes perspective expectation bioelectronics biomedical applications.
Language: Английский
Citations
19
Exploration, Journal Year: 2024, Volume and Issue: 4(5)
Published: March 14, 2024
Abstract Conductive polymer hydrogels (CPHs) are gaining considerable attention in developing wearable electronics due to their unique combination of high conductivity and softness. However, the absence interactions, incompatibility between hydrophobic conductive polymers (CPs) hydrophilic networks gives rise inadequate bonding CPs hydrogel matrices, thereby significantly impairing mechanical electrical properties CPHs constraining utility electronic sensors. Therefore, endow with good performance, it is necessary ensure a stable robust network CPs. Encouragingly, recent research has demonstrated that incorporating supramolecular interactions into enhances interaction, improving overall CPH performance. comprehensive review focusing on (SCPH) for sensing applications currently lacking. This provides summary typical strategies employed development high‐performance elucidates SCPHs closely associated Moreover, discusses fabrication methods classification SCPH sensors, while also exploring latest application scenarios Finally, challenges sensors offers suggestions future advancements.
Language: Английский
Citations
17
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)
Published: Nov. 29, 2023
Implantable hydrogel-based bioelectronics (IHB) can precisely monitor human health and diagnose diseases. However, achieving biodegradability, biocompatibility, high conformality with soft tissues poses significant challenges for IHB. Gelatin is the most suitable candidate IHB since it a collagen hydrolysate substantial part of extracellular matrix found naturally in tissues. This study used 3D printing ultrafine fiber networks metamaterial design to embed into ultra-low elastic modulus hydrogel create novel gelatin-based conductive film (GCF) mechanical programmability. The regulation GCF nearly covers tissue mechanics, an from 20 420 kPa, Poisson's ratio - 0.25 0.52. negative promotes improve efficiency biological interfaces. heartbeat signals respiratory rate by determining cardiac deformation due its conformability. Notably, gelatin characteristics biodegradable enable sensor support restoration. offers unique idea develop implantable sensors that integrate monitoring repair customized method endowing implanted be highly conformal
Language: Английский
Citations
31
Materials Horizons, Journal Year: 2023, Volume and Issue: 10(12), P. 5805 - 5821
Published: Jan. 1, 2023
An antibacterial, strong wet-tissue adhesive and biocompatible conductive hydrogel is proposed for next-generation bioelectronic materials in human healthcare.
Language: Английский
Citations
27
Biomaterials, Journal Year: 2024, Volume and Issue: 310, P. 122632 - 122632
Published: May 28, 2024
Language: Английский
Citations
14
ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1702 - 1713
Published: Jan. 2, 2024
Implantable neuroelectronic interfaces have gained significant importance in long-term brain-computer interfacing and neuroscience therapy. However, due to the mechanical geometrical mismatches between electrode-nerve interfaces, personalized compatible neural remain serious issues for peripheral neuromodulation. This study introduces stretchable flexible electronics class as a self-rolled interface neurological diagnosis modulation. These are made from liquid metal-polymer conductors with high resolution of 30 μm using microfluidic printing technology. They exhibit conformability stretchability (over 600% strain) during body movements good biocompatibility implantation 8 weeks). offer real-time monitoring epileptiform activities excellent soft brain tissue. The also develops electrodes that tightly wind deforming nerves minimal constraint (160 diameter).
Language: Английский
Citations
13
Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100960 - 100960
Published: Jan. 26, 2024
Chronic inflammation can delay wound healing, eventually leading to tissue necrosis and even cancer. Developing real-time intelligent monitoring treatment achieve effective management is important promote healing. In this study, a smart multifunctional hydrogel (Hydrogel@Au NCs&DG) was proposed monitor treat the inflammation. It prepared by mixing 3-carboxy-phenylboronic acid modified chitosan (CS-cPBA), β-glycerophosphate (β-GP), albumin-protected gold nanoclusters (BSA-Au NCs), dipotassium glycyrrhizinate (DG) about 10 s. hydrogel, CS-cPBA β-GP are crosslinked together boric ester bond hydrogen form main network, endowing with self-healing injectable properties adapt irregular wounds. Importantly, as-prepared good biocompatibility excellent adhesion property could directly determine H2O2 microenvironment visible fluorescence change of BSA-Au NCs then guide frequency dressing eliminate The results demonstrated that be expected serve as an inflammation-infected
Language: Английский
Citations
11
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(18), P. 10435 - 10508
Published: Sept. 16, 2024
The mechanical properties of polymer gels devote to emerging devices and machines in fields such as biomedical engineering, flexible bioelectronics, biomimetic actuators, energy harvesters. Coupling network architectures interactions has been explored regulate supportive characteristics gels; however, systematic reviews correlating mechanics interaction forces at the molecular structural levels remain absent field. This review highlights engineering gel a comprehensive mechanistic understanding regulation. Molecular alters architecture manipulates functional groups/moieties level, introducing various permanent or reversible dynamic bonds dissipative energy. usually uses monomers, cross-linkers, chains, other additives. Structural utilizes casting methods, solvent phase regulation, mechanochemistry, macromolecule chemical reactions, biomanufacturing technology construct tailor topological structures, heterogeneous modulus compositions. We envision that perfect combination may provide fresh view extend exciting new perspectives this burgeoning also summarizes recent representative applications with excellent properties. Conclusions are provided from five aspects concise summary, mechanism, biofabrication upgraded applications, synergistic methodology.
Language: Английский
Citations
11