A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 29, 2024

Abstract Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the bone health of patients with diabetes; however, currently, there are no effective treatment strategies. In diabetes, increased levels ferroptosis affect osteogenic commitment and differentiation mesenchymal stem cells (BMSCs), leading skeletal changes. To address this issue, we aimed target propose novel therapeutic approach for DOP. We synthesized ferroptosis-suppressing nanoparticles, which could deliver curcumin, natural compound, marrow using tetrahedral framework nucleic acid (tFNA). This delivery system demonstrated excellent curcumin bioavailability stability, as well synergistic properties tFNA. Both in vitro vivo experiments revealed nanoparticles enhance mitochondrial function by activating nuclear factor E2-related 2 (NRF2)/glutathione peroxidase 4 (GPX4) pathway, inhibiting ferroptosis, promoting BMSCs diabetic microenvironment, reducing trabecular loss, increasing formation. These findings suggest curcumin-containing DNA tetrahedron-based have promising potential DOP other ferroptosis-related diseases.

Language: Английский

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Macrocycles-assembled AIE supramolecular polymer networks

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 507, P. 215717 - 215717

Published: March 5, 2024

Language: Английский

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Biomimetic Self‐Propelled Asymmetric Nanomotors for Cascade‐Targeted Treatment of Neurological Inflammation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: March 9, 2024

Abstract The precise targeted delivery of therapeutic agents to deep regions the brain is crucial for effective treatment various neurological diseases. However, achieving this goal challenging due presence blood‒brain barrier (BBB) and complex anatomy brain. Here, a biomimetic self‐propelled nanomotor with cascade targeting capacity developed inflammatory nanomotors are designed asymmetric structures mesoporous SiO 2 head multiple MnO tentacles. Macrophage membrane modification endows BBB penetration abilities catalyze degradation H O into , not only by reducing inflammation but also providing driving force penetration. Additionally, loaded curcumin, which actively regulates macrophage polarization from M1 M2 phenotype. All in vitro cell, organoid model, vivo animal experiments confirmed effectiveness targeting, penetration, anti‐inflammatory, nervous system function maintenance. Therefore, study introduces platform ability active

Language: Английский

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Macrophage based drug delivery: Key challenges and strategies

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 55 - 72

Published: April 23, 2024

As a natural immune cell and antigen presenting cell, macrophages have been studied engineered to treat human diseases. Macrophages are well-suited for use as drug carriers because of their biological characteristics, such excellent biocompatibility, long circulation, intrinsic inflammatory homing phagocytosis. Meanwhile, macrophages' uniquely high plasticity easy re-education polarization facilitates part efficacious therapeutics the treatment diseases or tumors. Although recent studies demonstrated promising advances in macrophage-based delivery, several challenges currently hinder further improvement therapeutic effect clinical application. This article focuses on main utilizing from selection macrophage sources, loading, maintenance phenotypes, migration release at target sites. In addition, corresponding strategies insights related these described. Finally, we also provide perspective shortcomings road translation production.

Language: Английский

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Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Language: Английский

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In vivoapplications of micro/nanorobots

Nanoscale, Journal Year: 2023, Volume and Issue: 15(19), P. 8491 - 8507

Published: Jan. 1, 2023

Untethered robots in the size range of micro/nano-scale offer unprecedented access to hard-to-reach areas body. In these challenging environments, autonomous task completion capabilities micro/nanorobots have been subject research recent years. However, most studies presented preliminary vitro results that can significantly differ under vivo settings. Here, we focus on conducted with animal models reveal current status micro/nanorobotic applications real-world conditions. By a categorization based target locations, highlight main strategies employed organs and other body parts. We also discuss key challenges require interest before successful translation clinic.

Language: Английский

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Cell-mediated nanoparticle delivery systems: towards precision nanomedicine

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(11), P. 3032 - 3054

Published: April 13, 2024

Cell-mediated nanoparticle delivery systems (CMNDDs) utilize cells as carriers to deliver the drug-loaded nanoparticles. Unlike traditional drug approaches, CMNDDs take advantages of cell characteristics, such homing capabilities stem cells, inflammatory chemotaxis neutrophils, prolonged blood circulation red and internalization macrophages. Subsequently, can easily prolong circulation, cross biological barriers, blood-brain barrier bone marrow-blood barrier, rapidly arrive at diseased areas. Such advantageous properties make promising candidates for precision targeting. In this review, we summarize recent advances in fabrication biomedical applications. Specifically, ligand-receptor interactions, non-covalent covalent are commonly applied constructing vitro. By hitchhiking macrophages, monocytes, platelets, nanoparticles be internalized or attached construct vivo. Then highlight application treating different diseases, cancer, central nervous system disorders, lung cardiovascular with a brief discussion about challenges future perspectives end.

Language: Английский

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A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Dec. 10, 2023

Abstract The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the therapeutic outcome anticancer treatment. Major challenges lie in complexity diverse biological barriers that drug delivery systems must hierarchically overcome to reach their cellular/subcellular targets. Herein, an “all‐in‐one” red blood cell (RBC)‐derived microrobot can adapt five critical stages during systemic delivery, is, circulation, accumulation, release, extravasation, and penetration, is developed. microrobots behave like natural RBCs due almost identical surface properties, but be magnetically manipulated accumulate at regions interest such as tumours. Next, are “immolated” under laser irradiation release cargoes and, by generating heat, enhance extravasation through vascular barriers. As a coloaded agent, pirfenidone (PFD) inhibit formation extracellular matrix increase penetration depth solid tumour. It demonstrated this system effectively suppresses both primary metastatic tumours mouse models without evident side effects, may represent new class intelligent biomimicking robots for biomedical applications.

Language: Английский

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A Biomimetic Multifunctional Nanoframework for Symptom Relief and Restorative Treatment of Acute Liver Failure

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 31, 2024

Acute liver failure (ALF) is a rare and serious condition characterized by major hepatocyte death dysfunction. Owing to the limited therapeutic options, this disease generally has poor prognosis high mortality rate. When ALF cannot be reversed medications, transplantation often needed. However, transplant rejection shortage of donor organs still remain challenges. Most recently, stem cell therapy emerged as promising alternative for treatment diseases. delivery routes stability live products have greatly hindered feasibility efficacy therapy. Inspired functions mesenchymal cells (MSCs) primarily through secretion several factors, we developed an MSC-inspired biomimetic multifunctional nanoframework (MBN) that encapsulates growth-promoting factors secreted MSCs via combination with hydrophilic or hydrophobic drugs. The red blood (RBC) membrane was coated MBN enhance its immunological tolerance prolong circulation time in blood. Importantly, can respond oxidative microenvironment, where it accumulates degrades release payload. In work, two nanoparticles, namely, rhein-encapsulated (RMBN) N-acetylcysteine (NAC)-encapsulated (NMBN), were designed synthesized. lipopolysaccharide (LPS)/d-galactosamine (D-GalN)-induced acetaminophen (APAP)-induced mouse models, RMBN NMBN could effectively target lesions, relieve acute symptoms ALF, promote regeneration virtue their strong antioxidative, anti-inflammatory, regenerative activities. This study demonstrated use treating ALF.

Language: Английский

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Efferocytosis‐Inspired Biomimetic Nanoplatform for Targeted Acute Lung Injury Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 2, 2024

Acute lung injury (ALI) is a serious inflammatory disease that causes impairment of pulmonary function. Phenotypic modulation macrophage in the using fibroblast growth factor 21 (FGF21) may be potential strategy to alleviate inflammation. Consequently, achieving specific delivery FGF21 inflamed and subsequent efficient internalization by macrophages within becomes critical for effective ALI treatment. Here, an apoptotic cell membrane-coated zirconium-based metal-organic framework UiO-66 reported precise (ACM@U-FGF21) whose design inspired process efferocytosis. ACM@U-FGF21 with signals recognized internalized phagocytes blood lung, then intracellular can inhibit excessive secretion pro-inflammatory cytokines these cells relieve Utilizing homologous targeting properties inherited from source spontaneous recruitment immune sites, accumulate preferentially after injection. The results prove effectively reduces damage modulating polarization suppressing activated cells. This study demonstrates usefulness efferocytosis-inspired treatment ALI.

Language: Английский

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