Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 3, 2024
Abstract
Given
the
unique
anatomy
and
location
of
inflammatory
bowel
disease
(IBD),
oral
pharmacological
treatment
is
mainstay
for
managing
IBD
because
its
convenience
direct
accessibility
to
gastrointestinal
tract.
However,
efficient
delivery
systems
must
be
designed
navigate
harsh
environment
during
application.
Here,
an
innovative
drug
system
was
proposed
using
nanomotor
(NM)‐loaded
soluble
microcapsules
treating
IBD.
MnO
2
‐Au‐mSiO
NMs
incorporate
partially
encapsulated
antennas
that
convert
reactive
oxygen
species
into
oxygen,
autonomously
propelling
NMs.
Astaxanthin
(AST),
known
anti‐inflammatory
properties,
loaded
mesoporous
silica
(mSiO
)
(AST@NMs).
AST
effectively
reduces
inflammation
shifts
macrophages
from
a
proinflammatory
(M1)
phenotype
(M2)
phenotype.
To
protect
nanomotors
digestive
conditions
achieve
intestinal‐responsive
release,
photocurable
3D
printing,
we
fabricated
enteric‐coated
(MCs).
Additionally,
prevent
leakage
AST@NMs,
calcium
alginate
shell
cured
in
situ
on
surface
(AST@NMs@MCs).
In
vitro
vivo,
AST@NMs@MCs
reduced
inflammation,
repaired
intestinal
barrier,
modulated
gut
microbiota.
These
findings
underscore
protective
effects
AST@NM,
highlighting
their
potential
as
promising
strategy
colitis.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(22)
Published: March 9, 2024
Abstract
The
precise
targeted
delivery
of
therapeutic
agents
to
deep
regions
the
brain
is
crucial
for
effective
treatment
various
neurological
diseases.
However,
achieving
this
goal
challenging
due
presence
blood‒brain
barrier
(BBB)
and
complex
anatomy
brain.
Here,
a
biomimetic
self‐propelled
nanomotor
with
cascade
targeting
capacity
developed
inflammatory
nanomotors
are
designed
asymmetric
structures
mesoporous
SiO
2
head
multiple
MnO
tentacles.
Macrophage
membrane
modification
endows
BBB
penetration
abilities
catalyze
degradation
H
O
into
,
not
only
by
reducing
inflammation
but
also
providing
driving
force
penetration.
Additionally,
loaded
curcumin,
which
actively
regulates
macrophage
polarization
from
M1
M2
phenotype.
All
in
vitro
cell,
organoid
model,
vivo
animal
experiments
confirmed
effectiveness
targeting,
penetration,
anti‐inflammatory,
nervous
system
function
maintenance.
Therefore,
study
introduces
platform
ability
active
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: March 17, 2025
Abstract
Following
the
discovery
of
bone
as
an
endocrine
organ
with
systemic
influence,
bone-brain
interaction
has
emerged
a
research
hotspot,
unveiling
complex
bidirectional
communication
between
and
brain.
Studies
indicate
that
brain
can
influence
each
other’s
homeostasis
via
multiple
pathways,
yet
there
is
dearth
systematic
reviews
in
this
area.
This
review
comprehensively
examines
interactions
across
three
key
areas:
bone-derived
factors
on
function,
effects
brain-related
diseases
or
injuries
(BRDI)
health,
concept
skeletal
interoception.
Additionally,
discusses
innovative
approaches
biomaterial
design
inspired
by
mechanisms,
aiming
to
facilitate
through
materiobiological
aid
treatment
neurodegenerative
bone-related
diseases.
Notably,
integration
artificial
intelligence
(AI)
highlighted,
showcasing
AI’s
role
expediting
formulation
effective
targeted
strategies.
In
conclusion,
offers
vital
insights
into
mechanisms
suggests
advanced
harness
these
clinical
practice.
These
offer
promising
avenues
for
preventing
treating
impacting
skeleton
brain,
underscoring
potential
interdisciplinary
enhancing
human
health.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 9, 2024
Abstract
The
existence
of
the
blood–brain
barrier
(BBB)
and
characteristics
immunosuppressive
microenvironment
in
glioblastoma
(GBM)
present
significant
challenges
for
targeted
GBM
therapy.
To
address
this,
a
biomimetic
hybrid
cell
membrane‐modified
dual‐driven
heterojunction
nanomotor
(HM@MnO
2
‐AuNR‐SiO
)
is
proposed
treatment.
These
nanomotors
are
designed
to
bypass
BBB
target
glioma
regions
by
mimicking
surface
macrophage
membranes.
More
importantly,
MnO
structure
enables
propulsion
through
near‐infrared‐II
(NIR‐II)
light
oxygen
bubbles,
allowing
effective
treatment
at
deep
tumor
sites.
Meanwhile,
plasmonic
AuNR‐MnO
heterostructure
facilitates
separation
electron–hole
pairs
generates
reactive
species
(ROS),
inducing
immunogenic
death
under
NIR‐II
laser
irradiation.
Furthermore,
reacts
release
Mn
2+
ions,
activating
cGAS‐STING
pathway
enhancing
antitumor
immunity.
In
vitro
vivo
experiments
demonstrate
that
these
achieve
active
targeting
infiltration,
promoting
M1
polarization,
dendritic
maturation,
effector
T‐cell
activation,
thereby
catalysis
immunotherapy
ROS
production
STING
activation.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12155 - 12155
Published: Nov. 12, 2024
The
interplay
between
functional
food
nutrients
and
neurosteroids
has
garnered
significant
attention
for
its
potential
to
enhance
stress
resilience
in
health
and/or
disease.
Several
bioactive
nutrients,
including
medicinal
herbs,
flavonoids,
bioavailable
polyphenol-combined
nanoparticles,
as
well
probiotics,
vitamin
D
omega-3
fatty
acids,
have
been
shown
improve
blood-brain
barrier
(BBB)
dysfunction,
endogenous
neurosteroid
homeostasis
brain
function.
These
can
inhibit
oxidative
neuroinflammation,
which
are
linked
the
pathogenesis
of
various
neurological
disorders.
Interestingly,
flavonoids
exhibit
dose-dependent
effects,
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
pathway
at
physiological/low
dose
(neurohormesis).
This
leads
upregulation
antioxidant
phase
II
genes
proteins
such
heme
oxygenase-1
(HO-1)
sirtuin-1
(Sirt1),
activated
by
curcumin
resveratrol,
respectively.
adaptive
neuronal
response
mechanisms
help
protect
against
reactive
oxygen
species
(ROS)
neurotoxicity.
Impaired
Nrf2
hormone
signaling
exacerbate
selective
vulnerability
neuroinflammatory
conditions,
contributing
onset
progression
neurodegenerative
psychiatric
disorders,
Alzheimer's
disease,
anxiety
depression
other
due
neurons
stress.
review
focuses
on
targeting
redox
regulate
BBB
damage
associated
with
altered
GABAergic
neurotransmission.
By
exploring
underlying
molecular
using
innovative
technologies,
we
aim
develop
promising
neuroprotective
strategies
personalized
nutritional
neuroregenerative
therapies
prevent
or
attenuate
ultimately
promoting
health.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: July 29, 2024
Abstract
Micro/nanomotors
represent
a
promising
class
of
drug
delivery
carriers
capable
converting
surrounding
chemical
or
external
energy
into
mechanical
power,
enabling
autonomous
movement.
Their
distinct
propulsive
force
distinguishes
them
from
other
carriers,
offering
significant
potential
for
enhancing
penetration
across
cellular
and
tissue
barriers.
A
comprehensive
understanding
micro/nanomotor
dynamics
with
various
power
sources
is
crucial
to
facilitate
their
transition
proof‐of‐concept
clinical
application.
In
this
review,
micro/nanomotors
are
categorized
three
classes
based
on
sources:
endogenously
stimulated,
exogenously
live
cell‐driven.
The
review
summarizes
the
mechanisms
governing
movements
under
these
explores
factors
influencing
motion.
Furthermore,
it
discusses
methods
controlling
movement,
encompassing
aspects
related
structure,
composition,
environmental
factors.
remarkable
exhibited
by
makes
valuable
biomedical
applications,
including
tumor
therapy,
bio‐detection,
bacterial
infection
inflammation
gastrointestinal
disease
remediation.
Finally,
addresses
challenges
prospects
application
micro/nanomotors.
Overall,
emphasizes
transformative
in
overcoming
biological
barriers
therapeutic
efficacy,
highlighting
applications
fields.
