J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Aug. 1, 2023

Molecular fluorophores emitting in the second near-infrared (NIR-II, 1000-1700 nm) window with strong optical harvesting and high quantum yields hold great potential for vivo deep-tissue bioimaging high-resolution biosensing. Recently, J-aggregates are harnessed to engineer long-wavelength NIR-II emitters show unique superiority tumor detection, vessel mapping, surgical navigation, phototheranostics due their bathochromic-shifted bands required slip-stacked arrangement aggregation state. However, despite preliminary progress of theoretical study structure-property relationships, further paradigms remain scarce lack on aggregated fashion. In this effort, how utilize specific molecular structure form packing motifs J-type exciton coupling is emphatically elucidated. First, several regulating strategies achieve containing intermolecular interactions external conditions positively summarized deeply analyzed. Then, recent reports theranostics systematically provide a clear reference direction promoting development organic fluorophores. Eventually, prospective efforts ameliorating clinical practices outlined.

Language: Английский

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Adding Flying Wings: Butterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for Photothermal Combating of Bacterial Biofilms

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(47), P. 25705 - 25715

Published: Nov. 16, 2023

The ever-increasing threats of multidrug-resistant bacteria and their biofilm-associated infections have bred a desperate demand for alternative remedies to combat them. Near-infrared (NIR)-absorbing photothermal agent (PTAs)-mediated therapy (PTT) is particularly attractive biofilm ablation thanks its superiorities noninvasive intervention, satisfactory antibacterial efficiency, less likelihood develop resistance. Herein, three butterfly-shaped aggregation-induced emission luminogens (AIEgens) with balanced nonradiative decay (for conducting PTT) radiative supplying fluorescence in the NIR-II optical window) are rationally designed imaging-assisted obliteration bacterial biofilms. After being encapsulated into cationic liposomes, AIEgens-fabricated nanoparticles can eradicate wide spectrum biofilms formed by Gram-positive (methicillin-resistant Staphylococcus aureus Enterococcus faecalis) Gram-negative (Escherichia coli Pseudomonas aeruginosa) upon an 808 nm laser irradiation. In vivo experiments firmly demonstrate that AIE liposomes excellent biocompatibility perform well both P. aeruginosa biofilm-induced keratitis mouse model MSRA skin infection model.

Language: Английский

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Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)

Published: Aug. 19, 2023

Abstract Recently, many organic optoelectronic materials (OOMs), especially those used in light‐emitting diodes (OLEDs), solar cells (OSCs), and field‐effect transistors (OFETs), are explored for biomedical applications including imaging photoexcited therapies. In this review, recently developed OOMs fluorescence imaging, photoacoustic photothermal therapy, photodynamic summarized. Relationships between their molecular structures, nanoaggregation photophysical mechanisms, properties various discussed. Mainly four kinds of covered: thermally activated delayed OLEDs, conjugated small molecules polymers OSCs, charge‐transfer complexes OFETs. Based on the unique optical properties, excitation light wavelength exciton dynamics, they respectively exploited suitable applications. This review is intended to serve as a bridge researchers area devices Moreover, it provides guidance selecting or modifying high‐performance uses. Current challenges future perspectives also discussed with hope inspiring further development efficient

Language: Английский

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Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677

Published: Jan. 31, 2024

Language: Английский

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Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Feb. 12, 2024

Abstract The fabrication of a multimodal phototheranostic platform on the basis single‐component theranostic agent to afford both imaging and therapy simultaneously, is attractive yet full challenges. emergence aggregation‐induced emission luminogens (AIEgens), particularly those emit fluorescence in second near‐infrared window (NIR‐II), provides powerful tool for cancer treatment by virtue adjustable pathway radiative/non‐radiative energy consumption, deeper penetration depth aggregation‐enhanced performance. Although bulky thiophene π‐bridges such as ortho ‐alkylated thiophene, 3,4‐ethoxylene dioxythiophene benzo[ c ]thiophene are commonly adopted construct NIR‐II AIEgens, subtle differentiation their behaviours has be comprehensively investigated. In this work, systematical investigations discovered that AIEgen BT‐NS bearing possesses acceptable intensity, efficient reactive oxygen species generation, high photothermal conversion efficiency. Eventually, using nanoparticles, unprecedented performance fluorescence/photoacoustic/photothermal imaging‐guided synergistic photodynamic/photothermal elimination tumors was demonstrated. This study thus offers useful insights into developing versatile systems clinical trials.

Language: Английский

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Tuning Shortwave‐Infrared J‐aggregates of Aromatic Ring‐Fused Aza‐BODIPYs by Peripheral Substituents for Combined Photothermal and Photodynamic Therapies at Ultralow Laser Power

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(11)

Published: Jan. 16, 2024

Abstract Achieving photothermal therapy (PTT) at ultralow laser power density is crucial for minimizing photo‐damage and allowing higher maximum permissible skin exposure. However, this requires agents to possess not just superior conversion efficiency (PCE), but also exceptional near‐infrared (NIR) absorptivity. J ‐aggregates, exhibit a significant redshift narrower absorption peak with extinction coefficient. Nevertheless, achieving predictable ‐aggregates through molecular design remains challenge. In study, we successfully induced desirable J‐ aggregation (λ abs max : 968 nm, ϵ: 2.96×10 5 M −1 cm , λ em 972 Φ FL 6.2 %) by tuning electrostatic interactions between π‐conjugated planes manipulating surface potential of aromatic ring‐fused aza‐BODIPY dyes. Notably, controlling the preparation method encapsulating dyes into F‐127 polymer, were able selectively generate H ‐/ respectively. Furthermore, exhibited two controllable morphologies: nanospheres nanowires. Importantly, shortwave‐infrared ‐aggregated nanoparticles impressive PCE 72.9 % effectively destroyed cancer cells mice‐tumors an 0.27 W −2 (915 nm). This phototherapeutic nano‐platform, which generates behavior, can controllably form / H‐ aggregates selectable aggregate morphology, valuable paradigm developing tumor‐treatment density.

Language: Английский

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An All‐Rounder for NIR‐II Phototheranostics: Well‐Tailored 1064 nm‐Excitable Molecule for Photothermal Combating of Orthotopic Breast Cancer

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(26)

Published: April 19, 2024

The second near-infrared (NIR-II, 1000-1700 nm) light-activated organic photothermal agent that synchronously enables satisfying NIR-II fluorescence imaging is highly warranted yet rather challenging on the basis of overwhelming nonradiative decay. Herein, such an agent, namely TPABT-TD, was tactfully designed and constructed via employing benzo[c]thiophene moiety as bulky electron donor/π-bridge tailoring peripheral molecular rotors. Benefitting from its high donor-acceptor strength finely modulated intramolecular motion, TPABT-TD simultaneously exhibits ultralong absorption in region, intense emission NIR-IIa (1300-1500 region nanoaggregates, conversion upon 1064 nm laser irradiation. Those intrinsic advantages endow nanoparticles with prominent fluorescence/photoacoustic/photothermal trimodal imaging-guided therapy against orthotopic 4T1 breast tumor negligible adverse effect.

Language: Английский

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Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Language: Английский

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A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics

Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)

Published: March 2, 2024

Abstract Photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) in the second near‐infrared (NIR‐II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that π‐extended porphyrins fused with one or two nanographene units (NGP‐1 and NGP‐2) can serve new class of NIR‐responsive organic agents, displaying absorption extending to ≈1000 ≈1400 nm NIR‐I NIR‐II windows, respectively. NGP‐1 NGP‐2 are dispersed water through encapsulation into self‐assembled nanoparticles (NPs), achieving high conversion efficiency 60% 69%, respectively, under 808 1064 laser irradiation. Moreover, NIR‐II‐active NGP‐2‐NPs demonstrated photoacoustic responses, along photostability biocompatibility, enabling PAI efficient PTT vivo.

Language: Английский

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Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

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