Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Near‐infrared
(NIR)
phototheranostics,
combining
photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT),
show
great
promise
for
cancer
diagnosis
treatment.
Organic
molecules
are
excellent
agents
(PTAs)
due
to
their
strong
NIR
absorption
biodegradability.
Typically,
achieving
good
response
involves
using
fused‐ring
backbones,
which
require
complex
synthesis
yield
lower
production.
In
this
work,
2F
nanoparticles
(NPs)
reported
as
an
organic
phototheranostic
agent
with
high
responses,
synthesized
in
just
two
simple
steps
87%
production
efficient
PAI‐guided
PTT
of
cancer.
Unlike
traditional
structures,
is
formed
by
joining
donor
acceptor
moieties
carbon–carbon
bonds,
simplifying
increasing
yield.
Although
isolated
have
absorption,
forming
NPs
shifts
the
peak
from
708
808
nm,
comparable
state‐of‐the‐art
phototheranostics.
This
shift
significant
charge
transfer
between
dimers,
a
single‐component
charge‐transfer
improved
shown
spectra
theoretical
studies.
Finally,
demonstrate
successful
under
excitation
anti‐tumor
performance.
work
provides
valuable
insight
into
both
photophysical
performance
PTAs,
advancing
development
PTT.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(7)
Published: June 22, 2024
Photodynamic
therapy
(PDT)
is
a
temporally
and
spatially
precisely
controllable,
noninvasive,
potentially
highly
efficient
method
of
phototherapy.
The
three
components
PDT
primarily
include
photosensitizers,
oxygen,
light.
employs
specific
wavelengths
light
to
active
photosensitizers
at
the
tumor
site,
generating
reactive
oxygen
species
that
are
fatal
cells.
Nevertheless,
traditional
have
disadvantages
such
as
poor
water
solubility,
severe
oxygen-dependency,
low
targetability,
difficult
penetrate
deep
tissue,
which
remains
toughest
task
in
application
clinic.
Here,
we
systematically
summarize
development
molecular
mechanisms
challenges
management,
highlighting
advantages
nanocarriers-based
against
cancer.
third
generation
has
opened
up
new
horizons
PDT,
cooperation
between
nanocarriers
attained
satisfactory
achievements.
Finally,
clinical
studies
discussed.
Overall,
present
an
overview
our
perspective
field
believe
this
work
will
provide
insight
into
tumor-based
PDT.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: May 21, 2024
Fluorescence
imaging
(FLI)-guided
phototheranostics
using
emission
from
the
second
near-infrared
(NIR-II)
window
show
significant
potential
for
cancer
diagnosis
and
treatment.
Clinical
imaging-used
polymethine
ionic
indocyanine
green
(ICG)
dye
is
widely
adopted
NIR
fluorescence
imaging-guided
photothermal
therapy
(PTT)
research
due
to
its
exceptional
photophysical
properties.
However,
ICG
has
limitations
such
as
poor
photostability,
low
conversion
efficiency
(PCE),
short-wavelength
peak,
liver-targeting
issues,
which
restrict
wider
use.
In
this
study,
two
derivatives
are
transformed
into
neutral
merocyanines
(mCy)
achieve
much-enhanced
performance
NIR-II
phototheranostics.
Initial
designs
of
dyes
similar
drawbacks
in
terms
photostability
performance.
One
modified
molecules,
mCy890,
shows
significantly
improved
stability,
an
peak
over
1000
nm,
a
high
PCE
51%,
all
considerably
outperform
ICG.
vivo
studies
demonstrate
that
nanoparticles
mCy890
can
effectively
accumulate
at
tumor
sites
guided
by
imaging.
This
provides
valuable
insights
development
enhanced
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(22), P. 6767 - 6777
Published: May 21, 2024
Efforts
to
prolong
the
blood
circulation
time
and
bypass
immune
clearance
play
vital
roles
in
improving
therapeutic
efficacy
of
nanoparticles
(NPs).
Herein,
a
multifunctional
nanoplatform
(BPP@RTL)
that
precisely
targets
tumor
cells
is
fabricated
by
encapsulating
ultrasmall
phototherapeutic
agent
black
phosphorus
quantum
dot
(BPQD),
chemotherapeutic
drug
paclitaxel
(PTX),
immunomodulator
PolyMetformin
(PM)
hybrid
membrane-camouflaged
liposomes.
Specifically,
cell
membrane
coating
derived
from
fusion
cancer
red
displays
excellent
targeting
efficiency
long
property
due
innate
features
both
membranes.
After
collaboration
with
aPD-L1-based
checkpoint
blockade
therapy,
boosted
immunotherapeutic
effect
obtained
elevated
dendritic
maturation
T
activation.
Significantly,
laser-irradiated
BPP@RTL
combined
aPD-L1
effectively
eliminates
primary
tumors
inhibits
lung
metastasis
4T1
breast
model,
offering
promising
treatment
plan
develop
personalized
antitumor
strategy.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
The
two
contradictory
entities
in
nature
often
follow
the
principle
of
unity
opposites,
leading
to
optimal
overall
performance.
Particularly,
aggregation-induced
emission
luminogens
(AIEgens)
with
donor–acceptor
(D–A)
structures
exhibit
tunable
optical
properties
and
versatile
functionalities,
offering
significant
potential
revolutionize
cancer
treatment.
However,
trapped
by
low
molar
absorptivity
(ε)
owing
distorted
configurations,
ceilings
their
photon-harvesting
capability
corresponding
phototheranostic
performance
still
fall
short.
Therefore,
a
research
paradigm
from
twisted
configuration
near-planar
structure
featuring
high
ε
is
urgently
needed
for
AIEgens
development.
Herein,
introducing
strategy
"motion
stillness"
into
highly
planar
A–D–A
skeleton,
we
successfully
developed
near-infrared
(NIR)-II
AIEgen
Y5-2BO-2BTF,
which
boasts
an
impressive
1.06
×
105
M–1
cm–1
photothermal
conversion
efficiency
(PCE)
77.8%.
modification
steric
hindrance
on
benzene
ring
acceptor
unit
aggregation-caused
quenching
counterpart
Y5-2BO,
meta-CF3-substituted
naphthyl,
leads
reversely
staggered
packing
various
intermolecular
noncovalent
conformational
locks
Y5-2BO-2BTF
("stillness").
Furthermore,
−CF3
moiety
acted
as
flexible
motion
ultralow
energy
barrier,
significantly
facilitating
process
loose
aggregates
("motion").
Accordingly,
nanoparticles
enabled
tumor
eradication
pulmonary
metastasis
inhibition
through
NIR-II
fluorescence-photoacoustic-photothermal
imaging-navigated
type
I
photodynamic-photothermal
therapy.
This
work
provides
first
evidence
that
conformation
stacking
arrangement
could
serve
novel
molecular
design
direction
AIEgens,
shedding
new
light
constructing
superior
agents
bioimaging
Energy & Environmental Science,
Journal Year:
2024,
Volume and Issue:
17(14), P. 4944 - 4967
Published: Jan. 1, 2024
Quinoxaline-based
nonfullerene
acceptors
show
highly
tunable
photoelectric
properties
and
superior
performance
for
sunlight
utilization
enabled
by
their
powerful
core-functionalization
ability.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Recent
advances
have
been
made
in
second
near-infrared
(NIR-II)
fluorescence
bioimaging
and
many
related
applications
because
of
its
advantages
deep
penetration,
high
resolution,
minimal
invasiveness,
good
dynamic
visualization.
To
achieve
high-performance
NIR-II
bioimaging,
various
materials
probes
with
bright
emission
extensively
explored
the
past
few
years.
Among
these
emissive
materials,
conjugated
polymers
small
molecules
attracted
wide
interest
due
to
their
native
biosafety
tunable
optical
performance.
This
review
summarizes
brightness
strategies
available
for
highlights
recent
developments
bioimaging.
A
concise,
detailed
overview
molecular
design
regulatory
approaches
is
provided
terms
brightness,
long
wavelengths,
superior
imaging
Then,
typical
cases
which
are
used
as
introduced
by
providing
step-by-step
examples.
Finally,
current
problems
challenges
associated
accessing
briefly
discussed,
significance
future
prospects
proposed
offer
helpful
guidance
development
materials.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 2, 2024
Abstract
Recent
advances
are
achieved
in
the
design
and
development
of
efficient
organic
photosensitizers
(PSs),
especially
with
fluorescence
imaging
navigation
second
near‐infrared
(NIR‐II,
1000–1700
nm)
region.
However,
there
simply
a
handful
NIR‐II
emissive
PSs
oxygen‐independent
capability
due
to
scarcity
high‐performance
NIR‐responsive
materials
targeted
delivery.
Herein,
NIR‐II‐emissive
nanomedicine
biomimetic
engineering
for
multiple
phototherapies
pancreatic
tumors
is
reported.
An
A‐D‐A‐type
conjugated
small‐molecule
TPC
designed
used
prepare
water‐dispersive
nanoparticles,
which
demonstrated
high
efficiency
type
I
II
photodynamic
performances,
good
photothermal
conversion
57%,
bright
emission
quantum
yield
9.8%
under
808
nm
light
irradiation.
With
cancer
cell
membrane
camouflage,
high‐resolution
bioimaging
whole‐body
blood
vessels
tumors.
Antitumor
experiments
tumor
elimination
biosafety
This
work
versatile
enhanced
tumor‐targeting
superior
phototheranostics,
providing
feasible
idea
evolution
theranostics.
The
application
of
optoelectronic
nanomaterials
in
biosensing
has
become
a
hot
area
current
research.
Photoelectrochemical
have
unique
optical,
electrical,
and
chemical
properties
that
give
them
great
potential
the
design
biosensors.
This
paper
reviews
applications
photoelectric
biosensing.
First,
two
core
components
photoelectrochemical
biosensors
(photoelectrochemical
biorecognition
elements)
are
introduced,
different
types
nanomaterials,
such
as
inorganic,
organic,
composite
materials,
well
common
classifications
elements
discussed.
factors
influencing
photocurrent
signals,
signal
amplification,
bursting
strategies
then
In
addition,
four
field
bioanalysis
presented,
including
direct
detection,
enzyme
nucleic
acid
immunoassay.
Finally,
challenges
clinical
summarized.
is
expected
to
provide
more
sensitive
selective
detection
means
for
life
science
research
diagnosis
promote
further
development
technology.