An NIR‐II Two‐Photon Excitable AIE Photosensitizer for Precise and Efficient Treatment of Orthotopic Small‐Size Glioblastoma DOI Open Access
Zhourui Xu, Xue Li, Zeng‐Ming Yang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by second near-infrared (NIR-II) light, offers an unprecedented opportunity address this challenge, attributed its combinational merits PDT TP excitation. However, attempt has not been explored yet. On other hand, lack high-performance photosensitizers (PSs) also hinders progress TP-PDT on GBM. Based those, robust TP-PS, termed MeTTh, constructed intendedly through elaborately integrating multiple beneficial design strategies into single molecule, which simultaneously achieves excellent NIR-II excitation, large absorption cross-section, aggregation-induced NIR-I emission, prominent Type I/II reactive oxygen species generation. Aided nanofabrication, impressive brain structure imaging depth 940 µm realized. Moreover, MeTTh nanoparticles smoothly implement precise efficient treatment GBM in vivo under 1040 nm femtosecond laser irradiation. This study represents first-in-class using GBM, offering new insights for complex vital tissues.

Language: Английский

Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies DOI Creative Commons

Wanchen Zhao,

Liqing Wang,

Meihong Zhang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: June 22, 2024

Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.

Language: Английский

Citations

26
Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics DOI
Yingpeng Wan, Weilong Chen,

Ying Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Language: Английский

Citations

25
Black Phosphorus Quantum Dot Loaded Bioinspired Nanoplatform Synergized with aPD-L1 for Multimode Cancer Immunotherapy DOI

Yuqi Cao,

Lu Tang,

Cong Fu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(22), P. 6767 - 6777

Published: May 21, 2024

Efforts to prolong the blood circulation time and bypass immune clearance play vital roles in improving therapeutic efficacy of nanoparticles (NPs). Herein, a multifunctional nanoplatform (BPP@RTL) that precisely targets tumor cells is fabricated by encapsulating ultrasmall phototherapeutic agent black phosphorus quantum dot (BPQD), chemotherapeutic drug paclitaxel (PTX), immunomodulator PolyMetformin (PM) hybrid membrane-camouflaged liposomes. Specifically, cell membrane coating derived from fusion cancer red displays excellent targeting efficiency long property due innate features both membranes. After collaboration with aPD-L1-based checkpoint blockade therapy, boosted immunotherapeutic effect obtained elevated dendritic maturation T activation. Significantly, laser-irradiated BPP@RTL combined aPD-L1 effectively eliminates primary tumors inhibits lung metastasis 4T1 breast model, offering promising treatment plan develop personalized antitumor strategy.

Language: Английский

Citations

18
Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics DOI
Shiping Yang, Qian Jia, Xinwen Ou

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

Citations

5
Quinoxaline-based nonfullerene acceptors with powerful core-functionalization ability enabling efficient solar energy utilization DOI
Kerui Liu, Yuanyuan Jiang,

Feng Liu

et al.

Energy & Environmental Science, Journal Year: 2024, Volume and Issue: 17(14), P. 4944 - 4967

Published: Jan. 1, 2024

Quinoxaline-based nonfullerene acceptors show highly tunable photoelectric properties and superior performance for sunlight utilization enabled by their powerful core-functionalization ability.

Language: Английский

Citations

16
Phototherapy: progress, challenges, and opportunities DOI
Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

16
Light-responsive Au@Zn-TCPP nanozyme functionalized with cell-penetrating peptide and antisense oligonucleotide for sensing living bacteria and synergistic therapy of diabetic wounds DOI
Xuan Zhang, Yijun Liu, Qiuyan Guo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150945 - 150945

Published: April 2, 2024

Language: Английский

Citations

12
A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors DOI
Yiwei Wang, Jie Zhang, Yu Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.

Language: Английский

Citations

12
Brightness Strategies toward NIR-II Emissive Conjugated Materials: Molecular Design, Application, and Future Prospects DOI
Xiliang Li, Huan Chen,

Zihan Su

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.

Language: Английский

Citations

10
Photoelectrochemical Nanomaterials for Biosensing Applications DOI Open Access
Qianqian Sun,

Piaoping Yang

Published: Jan. 3, 2025

The application of optoelectronic nanomaterials in biosensing has become a hot area current research. Photoelectrochemical have unique optical, electrical, and chemical properties that give them great potential the design biosensors. This paper reviews applications photoelectric biosensing. First, two core components photoelectrochemical biosensors (photoelectrochemical biorecognition elements) are introduced, different types nanomaterials, such as inorganic, organic, composite materials, well common classifications elements discussed. factors influencing photocurrent signals, signal amplification, bursting strategies then In addition, four field bioanalysis presented, including direct detection, enzyme nucleic acid immunoassay. Finally, challenges clinical summarized. is expected to provide more sensitive selective detection means for life science research diagnosis promote further development technology.

Language: Английский

Citations

1