Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Due
to
the
strong
light
trapping
ability,
good
biocompatibility,
and
easily
regulated
molecular
structure,
conjugated
polymers
are
becoming
a
promising
tool
for
phototheranostics
of
tumors,
which
can
achieve
both
precise
diagnosis
efficient
therapeutics.
Of
particular
interest
is
polymer-based
theranostic
agents
applying
second
near-infrared
(NIR-II)
window
(1000–1700
nm),
exhibit
great
potential
clinical
applications
on
account
extremely
long
wavelength.
Herein,
basic
mechanism,
advances
in
recent
6
years,
perspectives
polymer
NIR-II
toward
tumor
discussed
successively.
First,
mechanisms
most
widely
employed
modalities
presented.
In
view
heat
generation
property
under
photoexcitation,
fluorescence
imaging
(FLI)-guided
photothermal
therapy
(PTT)
photoacoustic
(PAI)-guided
PTT.
Then,
related
FLI-guided
PTT
technology,
PAI-guided
multimodel
theranostics
introduced.
Finally,
development
illustrated
practical
application
simultaneously
situ
tumor.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(38)
Published: July 26, 2024
Abstract
One‐for‐all
phototheranostics
based
on
a
single
molecule
is
recognized
as
convenient
approach
for
cancer
treatment,
whose
efficacy
relies
precise
lesion
localization
through
multimodal
imaging,
coupled
with
the
efficient
exertion
of
phototherapy.
To
unleash
full
potential
phototheranostics,
advancement
in
both
phototheranostic
agents
and
light
delivery
methods
essential.
Herein,
an
integrated
strategy
combining
versatile
featuring
aggregation‐induced
emission,
namely
tBuTTBD,
modified
optical
fiber
to
realize
comprehensive
tumor
diagnosis
“inside‐out”
irradiation
orthotopic
breast
tumor,
proposed
first
time.
Attributed
intense
donor‐acceptor
interaction,
highly
distorted
conformation,
abundant
molecular
rotors,
loose
intermolecular
packing
upon
aggregation,
tBuTTBD
can
synchronously
undergo
second
near‐infrared
(NIR‐II)
fluorescence
photothermal
photodynamic
generation
under
laser
irradiation,
contributing
trimodal
NIR‐II
fluorescence‐photoacoustic
(PA)‐photothermal
imaging‐guided
The
treatment
further
carried
out
following
insertion
fiber,
which
fabricated
by
splicing
flat‐end
air‐core
fiber.
This
configuration
aims
enable
effective
situ
phototherapy
maximizing
energy
utilization
therapeutic
benefits.
work
not
only
enriches
palette
but
also
provides
valuable
insight
exploring
protocol
practical
treatment.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(26)
Published: April 19, 2024
Abstract
Fluorescence
sensing
is
crucial
to
studying
biological
processes
and
diagnosing
diseases,
especially
in
the
second
near‐infrared
(NIR‐II)
window
with
reduced
background
signals.
However,
it's
still
a
great
challenge
construct
“off‐on”
sensors
when
wavelength
extends
into
NIR‐II
region
obtain
higher
imaging
contrast,
mainly
due
difficult
synthesis
of
spectral
overlapped
quencher.
Here,
we
present
new
fluorescence
quenching
strategy,
which
utilizes
steric
hindrance
quencher
(SHQ)
tune
molecular
packing
state
fluorophores
suppress
emission
signal.
Density
functional
theory
(DFT)
calculations
further
reveal
that
large
SHQs
can
competitively
pack
prevent
their
self‐aggregation.
Based
on
this
mechanism,
novel
activatable
method
achieved
via
bio‐analyte
responsive
invalidation
SHQ,
namely
Steric
Hindrance
Invalidation
geNerated
Emission
(SHINE)
strategy.
As
proof
concept,
ClO
−
‐sensitive
SHQ
lead
bright
signal
release
epileptic
mouse
hippocampus
under
skull
high
photon
scattering
brain
tissue,
providing
real‐time
visualization
generation
process
living
mice.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 6, 2024
Abstract
Phototheranostics
with
second
near‐infrared
(NIR‐II)
emissions
show
great
potential
for
disease
diagnosis
and
imaging‐guided
phototherapy
owing
to
deep
tissue
penetration,
high
imaging
resolution,
excellent
tumor
eradication.
Recently,
molecular
conjugation
engineering
J‐aggregation
have
been
used
construct
organic
NIR‐II
materials.
However,
these
molecules
generally
extensive
large
weight
in
the
range
of
700–1700
g
mol
−1
,
requiring
complicated
design
synthesis.
Herein,
a
emissive
through‐space
charge‐transfer
(TSCT)
nanoparticle
(NP)
using
short‐conjugated
donor‐acceptor
(D‐A)
(TTP)
is
reported
high‐performance
bioimaging
cancer
phototheranostics.
Owing
short
TTP
molecule
small
only
518
monomer
possesses
visible
absorption
first
(NIR‐I)
emission.
Upon
forming
NPs
water,
efficient
TSCT
between
monomers
leads
significantly
red‐shifted
NIR‐I
emission
region
tail
that
extends
1400
nm.
are
employed
vivo
blood‐vessel
phototheranostics
successfully.
This
work
introduces
facile
strategy
based
on
D‐A
biomedical
applications.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(26)
Published: April 19, 2024
Fluorescence
sensing
is
crucial
to
studying
biological
processes
and
diagnosing
diseases,
especially
in
the
second
near-infrared
(NIR-II)
window
with
reduced
background
signals.
However,
it's
still
a
great
challenge
construct
"off-on"
sensors
when
wavelength
extends
into
NIR-II
region
obtain
higher
imaging
contrast,
mainly
due
difficult
synthesis
of
spectral
overlapped
quencher.
Here,
we
present
new
fluorescence
quenching
strategy,
which
utilizes
steric
hindrance
quencher
(SHQ)
tune
molecular
packing
state
fluorophores
suppress
emission
signal.
Density
functional
theory
(DFT)
calculations
further
reveal
that
large
SHQs
can
competitively
pack
prevent
their
self-aggregation.
Based
on
this
mechanism,
novel
activatable
method
achieved
via
bio-analyte
responsive
invalidation
SHQ,
namely
Steric
Hindrance
Invalidation
geNerated
Emission
(SHINE)
strategy.
As
proof
concept,
ClO
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
The
development
of
phototherapeutics
with
high
photothermal
conversion
efficiency
(PCE)
and
strong
ability
to
generate
reactive
oxygen
species
under
single
near-infrared
(NIR)
laser
irradiation
for
immuno-phototherapy
applications
remains
a
significant
challenge.
Herein,
we
optimally
selected
the
molecule
IT-4F
an
acceptor-donor-acceptor
(A-D-A)
structure
prepare
water-dispersible
nanoparticles
(NPs)
by
assembly
DSPE-PEG-NH2.
Such
NPs
have
NIR
absorption
fluorescence
peaks
at
728
817
nm,
respectively.
They
can
singlet
(1O2)
superoxide
anion
(O2-·)
irradiation,
1O2
generation
quantum
yield
31.5%.
also
effectively
convert
photon-energy
into
heat
PCE
42.8%.
outstanding
properties
enable
them
be
used
in
imaging
guided
therapy
(PTT),
photodynamic
(PDT).
Moreover,
PDT
PTT
triggered
immunogenic
cell
death
PANoptosis
tumor
cells,
which
not
only
inhibited
growth
metastasis
mice
model,
but
induced
robust
immune
response,
evidenced
increased
infiltration
CD8+
T
CD4+
dendritic
decreased
presence
immunosuppressive
cells
such
as
myeloid-derived
suppressor
regulatory
cells.
efficacy
organoid
human
breast
cancer
was
verified.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
The
sensitive
detection
of
the
radioactive
thorium
(Th)
ion
with
an
oxidation
state
+4
(Th4+)
is
great
significance
for
environmental
protection
and
life
safety.
In
this
study,
five
fluorescence
sensors
regulated
donor-acceptor
(D-A)
interactions
were
constructed
Th4+
based
on
intramolecular
charge
transfer
aggregation-induced
emission
mechanisms.
Among
developed
sensors,
TPE-D
bearing
electron-deficient
π-bridge
weak
D-A
presented
ratiometric
behavior
toward
in
aqueous
solution
due
to
its
characteristics
unique
D-A-D
structures.
Moreover,
showed
excellent
selectivity
sensitivity
detection,
limit
was
as
low
8.1
×
10-8
M.
sensing
mechanism
observation
revealed
that
could
coordinate
hydroxyl,
imine,
carbonyl
groups
accompanied
by
electron
process.
addition,
selectively
be
enriched
lysosome.
Both
lysosome
liver
mice
zebrafish
realized
strategy,
a
mobile-assisted
approach
actual
water
samples
also
established
high
sensitivity.
This
first
report
organelles
organs,
which
provides
reliable
strategy
radionuclide
toxicology
analysis
applications.
