Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 518 - 532
Published: March 12, 2024
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 420 - 443
Published: April 5, 2024
Language: Английский
Citations
32
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 543 - 555
Published: May 11, 2024
Language: Английский
Citations
29
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148768 - 148768
Published: Jan. 18, 2024
Language: Английский
Citations
27
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: Aug. 1, 2024
Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.
Language: Английский
Citations
27
Burns & Trauma, Journal Year: 2024, Volume and Issue: 12
Published: Jan. 1, 2024
Abstract The healing process at a wound is made up of many types cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex changing ways. Microbial colonization proliferation are possible place injury, which makes infection more likely. Because this, any cut has chance getting an infection. Researchers have found that infections make patients upset cost healthcare system lot money. Surgical site happen to people who recently had surgery. This study shows such surgical linked high rate illness death. shown by fact 25% get serious sepsis need be transferred intensive care unit. In both animal models people, mesenchymal stem cells (MSCs) play active role stages positive effects. Exosomes one main things MSCs release. They effects similar those parent MSCs. Various effector proteins, messenger RNA microRNAs can transported vesicles control activity target cells. big impact on process. These results suggest using MSC-exosomes as new type cell-free therapy could better safer option than whole cell therapy. review mostly about how use parts help heal.
Language: Английский
Citations
27
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129300 - 129300
Published: Jan. 11, 2024
Language: Английский
Citations
26
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150545 - 150545
Published: March 19, 2024
Language: Английский
Citations
25
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154855 - 154855
Published: Aug. 14, 2024
Language: Английский
Citations
21
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)
Published: April 15, 2024
Abstract Osteoclast hyperactivation stands as a significant pathological factor contributing to the emergence of bone disorders driven by heightened oxidative stress levels. The modulation redox balance scavenge reactive oxygen species emerges viable approach addressing this concern. Selenoproteins, characterized selenocysteine (SeCys 2 ) active center, are crucial for selenium‐based antioxidative therapy inflammatory diseases. This study reveals that surface‐active elemental selenium (Se) nanoparticles, particularly lentinan‐Se (LNT‐Se), exhibit enhanced cellular accumulation and accelerated metabolism SeCys , primary Se form in biological systems. Consequently, LNT‐Se demonstrates inhibition osteoclastogenesis. Furthermore, vivo studies underscore superior therapeutic efficacy over potentially attributable stability safety profile LNT‐Se. Specifically, effectively modulates expression selenoprotein GPx1, thereby exerting regulatory control osteoclastogenesis inhibition, prevention osteolysis. In summary, these results suggest prompt activation selenoproteins nanoparticles serves suppress loss upregulating GPx1. Moreover, utilization bioactive presents promising avenue managing disorders.
Language: Английский
Citations
20
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 10, 2024
The persistent challenge of healing infectious wounds and the rise bacterial resistance represent significant hurdles in contemporary medicine. In this study, based on natural small molecule drug Rhein self-assembly to form hydrogels coordinate assembly with silver ions (Ag
Language: Английский
Citations
20