Ultrasmall CuMn-His Nanozymes with Multienzyme Activity at Neutral pH: Construction of a Colorimetric Sensing Array for Biothiol Detection and Disease Identification

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34538 - 34548

Published: June 28, 2024

Biothiol assays offer vital insights into health assessment and facilitate the early detection of potential issues, thereby enabling timely effective interventions. In this study, we developed ultrasmall CuMn-Histidine (His) nanozymes with multiple enzymatic activities. CuMn-His enhanced peroxidase (POD)-like activity at neutral pH was achieved through hydrogen bonding electrostatic effects. addition, possesses laccase (LAC)-like superoxide dismutase (SOD)-like activities pH. Based on three different enzyme mimetic pH, colorimetric sensing array without changing buffer solution successfully constructed. The used for identification biothiols, glutathione (GSH), cysteine (Cys), homocysteine (Hcy). Subsequently, excellent application results were shown in complex serum cellular level analyses. This study provides an innovative strategy development bimetallic construction arrays.

Language: Английский

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Breaking through the pH Limitation of Fe_1–xS Nanozymes Using Component-Modulated Coupled Nanoclay

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(7), P. 3366 - 3375

Published: Feb. 7, 2024

Overcoming the intrinsic low activity of most peroxidase mimics under neutral pH is crucial but still extremely challenging for detection disease markers in biological samples. Here, we chose nanoclay (i.e., montmorillonite K10, MK10) as a carrier to modulate structure Fe

Language: Английский

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Gold Nanocluster-Based Nanozyme for High-Throughput Colorimetric Detection of SARS-CoV-2

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10660 - 10669

Published: April 23, 2024

There is an urgent need for efficient and convenient methods to detect SARS-CoV-2 as the global pandemic continues. Currently, detection of COVID-19 relies primarily on reverse transcription PCR (RT-PCR), a laboratory-based method that time-consuming. To tackle this challenge, study proposes immediate high-throughput platform SARS-CoV-2. The uses gold nanoenzymatic colorimetric assay focuses specific 3CLpro in has been extensively characterized stability, sensitivity, range, response time. not only provides easy-to-read results but also allows color readings be taken using smartphone, with accuracy comparable large instruments such microplate reader. innovation technology lies ability achieve instant detection, which makes rapid feasible. proposed wide range potential applications, particularly field virus providing reliable solution managing current pandemics future disease prevention control.

Language: Английский

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Ultrasensitive colorimetric detection of deoxynivalenol in infant milk powder based on the inhibitory effect of silver ions on the peroxidase-like activity of Ni@Pt nanoparticles

Food Chemistry, Journal Year: 2025, Volume and Issue: 472, P. 142947 - 142947

Published: Jan. 16, 2025

Language: Английский

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Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors

Nano Research, Journal Year: 2023, Volume and Issue: 17(4), P. 2451 - 2461

Published: Sept. 30, 2023

Language: Английский

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