Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 192 - 206
Published: July 3, 2024
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 531 - 531
Published: April 12, 2024
Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, challenges inadequate targeting limited biocompatibility persist. In recent years, cell membrane nano-biomimetic have emerged as a focal point research development, due to their exceptional traits, including precise targeting, low toxicity, good biocompatibility. This review outlines categorization advantages bionic nano-delivery systems, provides an introduction preparation methods, assesses applications in treatment, chemotherapy, gene therapy, immunotherapy, photodynamic photothermal combination therapy. Notably, delves into application various identifies opportunities future advancement. Embracing membrane-coated biomimetic nanoparticles presents novel unparalleled avenue personalized tumor
Language: Английский
Citations
18
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 94 - 107
Published: Feb. 4, 2025
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying
Language: Английский
Citations
3
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 445 - 472
Published: Oct. 26, 2023
Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.
Language: Английский
Citations
40
Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)
Published: July 6, 2023
The advent of immunotherapy has marked a new era in cancer treatment, offering significant clinical benefits. Cell membrane as drug delivery materials played crucial role enhancing therapy because their inherent biocompatibility and negligible immunogenicity. Different cell membranes are prepared into nanovesicles (CMNs), but CMNs have limitations such inefficient targeting ability, low efficacy, unpredictable side effects. Genetic engineering deepened the critical immunotherapy, enabling genetically engineered-CMN (GCMN)-based therapeutics. To date, that surface modified by various functional proteins been developed through genetic engineering. Herein, brief overview strategies for features sources is discussed, followed description GCMN preparation methods. application GCMNs directed at different immune targets addressed challenges prospects translation.
Language: Английский
Citations
33
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2071 - 2071
Published: Feb. 8, 2024
Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle faces challenges such as short circulation time immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested practical alternative. The production process involves three main stages: lysis membrane fragmentation, isolation, coating. Cell membranes are typically fragmented using hypotonic with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. Coating can be achieved extrusion, sonication, combination of both methods. Notably, this analysis reveals the absence universally applicable method for coating, stages differ significantly their procedures. This review explores current developments approaches nanoparticles, highlighting potential an effective alternative various therapeutic applications.
Language: Английский
Citations
15
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(5), P. 413 - 413
Published: Feb. 23, 2024
Recent strides in nanomaterials science have paved the way for creation of reliable, effective, highly accurate, and user-friendly biomedical systems. Pioneering integration natural cell membranes into sophisticated nanocarrier architectures, membrane camouflage has emerged as a transformative approach regulated drug delivery, offering benefits minimal immunogenicity coupled with active targeting capabilities. Nevertheless, utility such is curtailed by challenges like suboptimal precision lackluster therapeutic efficacy. Tailored engineering stands at forefront biomedicine, equipping nanoplatforms capacity to conduct more complex operations. This review commences an examination prevailing methodologies engineering, spotlighting strategies direct chemical modification, lipid insertion, hybridization, metabolic glycan labeling, genetic engineering. Following this, evaluation unique attributes various presented, delivering in-depth scrutiny substantial advancements applications driven cutting-edge engineered camouflage. The discourse culminates recapitulating salient influence within nanomaterial prognosticates its seminal role healthcare technologies. It envisaged that insights offered herein will catalyze novel avenues innovation refinement camouflaged nanotechnologies.
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)
Published: May 16, 2024
Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.
Language: Английский
Citations
9
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 672, P. 125336 - 125336
Published: Feb. 11, 2025
Language: Английский
Citations
1
Cancer Communications, Journal Year: 2024, Volume and Issue: 44(10), P. 1130 - 1167
Published: Aug. 1, 2024
The intratumoral microbiome (TM) refers to the microorganisms in tumor tissues, including bacteria, fungi, viruses, and so on, is distinct from gut circulating microbiota. TM strongly associated with tumorigenesis, progression, metastasis, response therapy. This paper highlights current status of TM. Tract sources, adjacent normal tissue, circulatory system, concomitant co-metastasis are main origin advanced techniques analysis comprehensively summarized. Besides, involved progression through several mechanisms, DNA damage, activation oncogenic signaling pathways (phosphoinositide 3-kinase [PI3K], signal transducer activator transcription [STAT], WNT/β-catenin, extracellular regulated protein kinases [ERK]), influence cytokines induce inflammatory responses, interaction microenvironment (anti-tumor immunity, pro-tumor microbial-derived metabolites). Moreover, promising directions therapy include immunotherapy, chemotherapy, radiotherapy, application probiotics/prebiotics/synbiotics, fecal transplantation, engineered microbiota, phage therapy, oncolytic virus inherent challenges clinical also review provides a comprehensive landscape for analyzing TM, especially TM-related mechanisms TM-based treatment cancer.
Language: Английский
Citations
8