Biomarker-driven molecular imaging probes in radiotherapy

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146

Published: Jan. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Language: Английский

---

Dendritic Polymer‐Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Antitumor Immune Response

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 12, 2024

Abstract The dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. A sequential treatment strategy remodeling the ECM via a CAF modifier (dasatinib, DAS) is proposed to promote an immunogenic cell death (ICD) inducer (epirubicin, Epi) apoptotic vesicles, ultimately enhancing efficacy against breast cancer. Dendritic poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)‐based nanomedicines (poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS] (P‐DAS) poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi] (P‐Epi)) are developed for delivery DAS Epi, respectively. P‐DAS reprograms CAFs reduce collagen downregulating anabolism energy metabolism, thereby reducing deposition. regulated can enhance tumor P‐Epi strengthen its ICD effect, leading amplified antitumor immune response. In cancer‐bearing mice, this approach alleviates barrier, resulting reduced burden increased cytotoxic T lymphocyte infiltration, more encouragingly, synergizes effectively with anti‐programmed 1 (PD‐1) therapy, significantly inhibiting growth preventing lung metastasis. Furthermore, systemic toxicity barely detectable after P‐Epi. This opens new avenue treating desmoplastic tumors metabolically targeting overcome barrier.

Language: Английский

---

Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101028 - 101028

Published: March 24, 2024

The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.

Language: Английский

---

Phase-separating Pt(IV)-graft-glycopeptides sequentially sensing pH and redox for deep tumor penetration and targeting chemotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 743 - 756

Published: Jan. 25, 2025

Language: Английский

---

Endoplasmic Reticulum-Targeted Polymer-Manganese Nanocomplexes for Tumor Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Manganese ions (Mn2+) are an immune activator that enhances the activation of both cGAS and STING proteins. The signaling subsequential responses predominantly associated with endoplasmic reticulum (ER). Therefore, ER targeting Mn2+ in subcellular compartments would promote pathways. Herein, we report design ER-targeted manganese-based nanocomplexes (NCs) by complexation a zwitterionic polymer, poly[2-(N-oxide-N,N-dimethylamino) ethyl methacrylate] (OPDMA). Mn/OPDMA (Mn/OPDMA NCs) keep long blood circulation for tumor accumulation trigger adsorption-mediated transcytosis extravasation deep penetration. Notably, tumor-associated macrophages, NCs can preferentially translocate to their ERs, significantly enhancing cGAS-STING pathway macrophage polarization IFN-β secretion. In mouse colon hepatocellular cancer models, intravenously administrated efficiently remodel microenvironment, greatly retard growths 2.4- 5-fold, prolong survivals compared free Mn2+-treated mice. This study provides delivery achieves robust and, thus, potent systemic inhibition without toxicity Mn2+.

Language: Английский

---

Nanomedicine in Immunotherapy for Non‐Small Cell Lung Cancer: Applications and Perspectives

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Non‐small cell lung cancer (NSCLC) has a strikingly high incidence rate globally. Although immunotherapy brings great breakthrough in its clinical treatment of NSCLC, significant challenges still need to be overcome. The development novel multi‐functional nanomedicines the realm tumor offers promising opportunities for NSCLC patients, as exhibit advantages, including specific targeting cells, improved drug bioavailability, reduced systemic toxicity, and overcoming immune resistance. In this review, core features current status strategies checkpoint blockade, antibody–drug conjugates, engagers, adoptive vaccines, are surveyed. Particular emphasis is placed on recent that boost these strategies. Nanomedicine can provide perspectives immunotherapy.

Language: Английский

---

Advancing functional foods: a systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 5, 2025

Plant-derived exosome-like nanoparticles (PDENs), emerging as novel bioactive agents, exhibit significant potential in food science and nutritional health. These nanoparticles, enriched with plant-specific biomolecules such proteins, lipids, nucleic acids, secondary metabolites, demonstrate unique cross-species regulatory capabilities, enabling interactions mammalian cells gut microbiota. PDENs enhance nutrient bioavailability by protecting sensitive compounds during digestion, modulate metabolic pathways through miRNA-mediated gene regulation, anti-inflammatory antioxidant properties. For instance, grape-derived reduce plasma triglycerides high-fat diets, while ginger-derived alleviate colitis downregulating pro-inflammatory cytokines. Additionally, serve natural drug carriers, applications delivering therapeutic agents like doxorubicin paclitaxel. Despite these advancements, challenges remain standardizing extraction methods (ultracentrifugation, immunoaffinity), ensuring stability processing storage, evaluating long-term safety. Current research highlights the need for optimizing lyophilization techniques understanding between matrices. Furthermore, show promise functional development—such fortified beverages probiotic formulations—their clinical translation requires rigorous pharmacokinetic studies clarity. This review synthesizes existing knowledge on PDENs’ composition, biological activities, applications, identifying gaps scalability, stability, safety assessments. Future directions emphasize interdisciplinary collaboration to harness combating disorders, enhancing functionality, advancing personalized nutrition strategies.

Language: Английский

---

Carrier-Free Nanodrugs: From Bench to Bedside

ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 23827 - 23841

Published: Aug. 20, 2024

Carrier-free nanodrugs with extraordinary active pharmaceutical ingredient (API) loading (even 100%), avoidable carrier-induced toxicity, and simple synthetic procedures are considered as one of the most promising candidates for disease theranostics. Substantial studies commercial success "carrier-free" nanocrystals have demonstrated their strong clinical potential. However, practical translations remain challenging impeded by unpredictable assembly processes, insufficient delivery efficiency, an unclear in vivo fate. In this Perspective, we systematically outline contemporary emerging carrier-free based on diverse APIs, well highlight opportunities challenges translation. Looking ahead, further improvements design preparation, drug delivery, efficacy, safety nanomedicines essential to facilitate translation from bench bedside.

Language: Английский

---

Intracellularly Synthesized Artificial Exosome Treats Acute Lung Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(32), P. 21009 - 21023

Published: Aug. 1, 2024

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), induce high morbidity mortality rates, which challenge the present approaches for treatment of ALI/ARDS. The clinically used photosensitizer verteporfin (VER) exhibits great potential in (ALI/ARDS) by regulating macrophage polarization reducing inflammation. Nevertheless, hydrophobic characteristics, nonspecificity, constrained bioavailability hinder therapeutic efficacy. In this work, we developed a type VER-cored artificial exosome (EVM), was produced using mesoporous silica nanoparticles (MSNs) to load VER, followed exocytosis internalized VER-MSNs from mouse bone marrow-derived mesenchymal stem cells (mBMSCs) without further modification. Both vitro vivo assessments confirmed powerful anti-inflammation induced EVM. EVM also showed significant higher accumulation inflammatory lungs compared with healthy ones, beneficial improved pulmonary function, attenuated injury, reduced ALI mice levels biocompatibility, exhibiting 5-fold survival rate than control. This emitted near-infrared light presence laser activation, endowed trackable ability both vivo. Our work photosensitizer-loaded membrane integrity traceability. To best our knowledge, kind intracellularly synthesized ALI/ARDS therapy.

Language: Английский

---

Biomimetic Nanoparticles for Cancer Therapy: A Review of Recent Advances, Applications, and Bottlenecks

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: April 8, 2024

Biomimetic nanoparticles (BioM NPs) feature functionalization that imitates the biological surroundings, endowing them with structure and functioning. BioM NPs could be covered biologically sourced materials contain synthetic antigen-presenting cells structures. Whenever used in cancer diagnostics, outperform standard medications comparable non-BioM NPs, particularly regarding circulation time, tissue penetration, delivery, toxicity. The particles achieved extraordinary results by using cell material for which avoids difficult bottom-up approaches aim to emulate such intricate diverse components. One area of this rapidly developing research has gotten a lot interest is use treatment different cancers. However, best our knowledge, no published study primarily analysed current improvements therapy, taking into account most common tumours processes. As result, purpose present review address gap first. discussion will next go numerous recent advances therapy. This cover mechanics procedures as well their utilization therapeutics. paper then summarizes existing knowledge investigates limitations promise aims provide researchers an overview technological development It serves guide integrating future nanomedicine applications.

Language: Английский

---