Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 16, 2024

Abstract Diabetic wounds are difficult to heal, and the key wound healing is exudate management effective disinfection. Inspired by asymmetric wettability of Janus‐structured lotus leaves, herein study has presented design a biomimetic Janus membrane that integrates unidirectional biofluid drainage photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic healing. This prepared electrospinning polyacrylonitrile (PAN) nanofiber containing polydopamine (PDA) on surface polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA enables antigravity “pumping” water from hydrophobic PP layer hydrophilic PAN within 22 s through contact points interface. The incorporation 30 wt% PDA in imparts high photoabsorption photothermal responsiveness, facilitating continuous volatilization exudate, achieving twice displacement water, causing irreversible damage bacteria. As result, it effectively alleviates inflammation cellular fibrosis while promoting collagen deposition due its structure antibacterial properties. Impressively, such achieves an impressive closure rate 96.7% wounds, better than (59.8%) conventional bandages. Therefore, this offers promising alternative chronic wounds.

Language: Английский

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A Viscous‐Biofluid Self‐Pumping Organohydrogel Dressing to Accelerate Diabetic Wound Healing

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 29, 2024

Abstract Viscous biofluids on wounds challenge conventional “water‐absorbing” wound dressings in efficient drainage due to their poor fluidity, generally causing prolonged inflammation, anti‐angiogenesis, and delayed closure. Herein, it is reported that a self‐pumping organohydrogel dressing (SPD) with aligned hydrated hydrogel channels, prepared by three‐dimensional‐templated wetting‐enabled‐transfer (3D‐WET) polymerization process, can efficiently drain viscous fluids accelerate diabetic healing. The asymmetric wettability of the hydrophobic–hydrophilic layers channels enable unidirectional away from wounds, preventing overhydration inflammatory stimulation. organogel layer adhere onto skin around but be easily detached wet area, avoiding secondary trauma newly formed tissues. Taking rat model as an example, SPD significantly downregulate inflammation response ≈70.8%, enhance dermal remodeling ≈14.3%, shorten closure time about 1/3 compared commercial (3M, Tegaderm hydrocolloid thin dressing). This study sheds light development next generation functional for chronic involving biofluids.

Language: Английский

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Thermo‐Responsive Trilayered Fibrous Dressing with Liquid Gate for Dynamical Exudate Regulation and Wound Moisture Balance

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)

Published: Jan. 6, 2024

Abstract Exudate plays a crucial role in wound healing, but an excessive amount can lead to over‐hydration of tissue and aggravating the infection injury. On other hand, inadequate exudate cause scarring hinder healing. Traditional dressings are unable regulate levels based on specific needs wound. To address this issue, liquid‐gated trilayered fibrous dressing capable pumping fluid temperature‐dependent manner is developed. This comprises hydrophilic cotton layer, thermo‐sensitive (TPPU) hydrophobic layer polyurethane (PU) nanofibers. The TPPU constituted by nanofibers that composed upper critical solution temperature (UCST)‐type polymer, PU, silver nanoparticles. intermediate exhibits changes its wettability upon heating, adjusting thickness ultimately achieving appropriate structure for guiding spontaneous transport. positive effect novel diabetic wounds observed, as it enhanced epithelialization collagen synthesis while reducing inflammation, accelerating healing process. has potential provide groundbreaking managing exudate, moisture balance promoting clinical settings.

Language: Английский

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Self-Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 2, 2024

Abstract Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances. It is vital to develop multifunctional hydrogel dressings, with well-designed morphology structure enhance flexibility effectiveness in wound management. To achieve these, we propose self-healing dressing based on structural color microspheres for The microsphere comprised photothermal-responsive inverse opal framework, which was constructed by hyaluronic acid methacryloyl, silk fibroin methacryloyl black phosphorus quantum dots (BPQDs), further re-filled dynamic hydrogel. filler formed Knoevenagel condensation reaction between cyanoacetate benzaldehyde-functionalized dextran (DEX-CA DEX-BA). Notably, the composite can be applied arbitrarily, they adhere together upon near-infrared irradiation leveraging BPQDs-mediated photothermal effect thermoreversible stiffness change Additionally, eumenitin vascular endothelial growth factor were co-loaded their release behavior regulated same mechanism. Moreover, effective monitoring drug process achieved through visual variations. system has demonstrated desired capabilities controllable efficient These characteristics suggest broad prospects proposed clinical applications.

Language: Английский

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A carboxymethyl cellulose/chitosan-based hydrogel harvests robust adhesive, on-demand detachment and self-healing performances for deep burn healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155552 - 155552

Published: Sept. 12, 2024

Language: Английский

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Interfacial fluid manipulation with bioinspired strategies: special wettability and asymmetric structures

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Bioinspired fluid manipulating interfaces possessing special wettability, an asymmetric structure, and a geometric gradient were systematically reviewed, including history, classification, mechanisms, fabrication applications.

Language: Английский

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Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2438 - 2448

Published: March 19, 2024

The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties strong applicability are urgently needed. Herein, we developed a composite by constructing multiple networks loading ciprofloxacin for wound healing. was synthesized via Schiff base reaction between carboxymethyl chitosan oxidized sodium alginate, followed polymerization acrylamide monomer. resultant dressing possessed good self-healing ability, considerable compression strength, reliable fatigue resistance. In vitro assessment showed that effectively eliminated bacteria exhibited an excellent biocompatibility. model

Language: Английский

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Opportunities and challenges of engineered exosomes for diabetic wound healing

Giant, Journal Year: 2024, Volume and Issue: 18, P. 100251 - 100251

Published: March 6, 2024

The treatment of diabetic wounds is a major challenge faced by the medical system, and there growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential skin repair, regenerative properties primarily attributed paracrine effects secreted products, including exosomes. Compared cell-based approaches, using exosomes as cell-free therapy for chronic several advantages. Exosomes can regulate intercellular communication releasing their contents, mRNA, miRNA, lipids, proteins, which further promote are well explored biomedical application owing advantages such biocompatibility low immunogenicity. However, common method exosome administration through injection, but due rapid clearance rate body, maintaining necessary therapeutic concentration around challenging. Therefore, it develop new biocompatible scaffold carrier extracellular vesicles, allowing them sustain at non-healing sites continuously Engineered kinds modified internal treated molecules, surface decoration or delivered engineered platform. In addition, some researchers have processed exosomes, known decoration, delivery platforms. regular greater promoting this review, we summarize molecular mechanisms from different sources varying modifications Advantages limitations repair were also discussed. Finally, highlight challenges future development directions translating our knowledge into clinical practice.

Language: Английский

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A Wound Exudate‐Activated Yarn Battery for Antimicrobial Electrical Fabric Dressing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: May 28, 2024

Abstract Excessive inflammation poses a major challenge to wound care, with massive exudation and bacterial infection being the prominent factors contributing inflammation. Current biomaterials can achieve passive or interactive repair through exudate absorption anti‐infection. However, they cannot actively modulate cellular behavior associated skin repair. Inspired by endogenous electric field (EF), present study develops an antimicrobial self‐powered electrical fabric dressing (EFD). An EFD multifunctional properties of collection, anti‐infection, stimulation (ES) is assembled via weaving series hydrophilically modified cotton yarn‐based batteries. Upon contact wound, absorbs owing its high hydrophilicity utilizes it as natural electrolyte activate battery. With power supply, ES‐promoted polarization macrophage, well migration proliferation fibroblasts, enhancing active process. Moreover, dressings exhibit excellent antibacterial properties, attributable synergistic effects cationic polymer brushes on yarn anodic by‐product (magnesium hydroxide) during discharging. Thus, exudate‐activated effectively manage exudates, prevent infection, provide electrotherapy facilitate tissue

Language: Английский

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Chitin nanofibrils assisted 3D printing all-chitin hydrogels for wound dressing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122028 - 122028

Published: March 6, 2024

Language: Английский

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