ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
The
development
of
reactive
oxygen
species
(ROS)-based
antibacterial
strategies
that
overcome
ROS's
ultrashort
diffusion
distance
and
disrupt
bacterial
electron
transfer
represents
a
promising
yet
underexplored
avenue
for
nonantibiotic
therapies.
In
this
study,
we
introduce
an
iron-copper
bimetallic
metal-organic
framework
(MOF)
with
peroxidase
(POD)-like
enzymatic
activity
engineered
to
integrate
dual
functionalities:
bactericidal
recognition
disruption
synergistically
enhance
efficacy.
Mechanistic
investigations
reveal
boronic-acid-cis-diol
interactions
enable
the
MOF
selectively
bind
membranes,
where
it
generates
localized
ROS,
effectively
killing
bacteria.
Concurrently,
alignment
energy
levels
redox
potential
facilitates
efficient
from
membrane
MOFs,
disrupting
integrity
inhibiting
critical
processes
such
as
transport
ATP
synthesis.
When
incorporated
into
biodegradable
microneedle
patches,
penetrates
biofilms
wound
exudates,
delivering
potent
effects
directly
infection
sites
while
simultaneously
promoting
tissue
repair.
This
strategic
combination
targeting,
disruption,
microneedle-mediated
delivery
highlights
approach
advance
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(35), P. 24327 - 24349
Published: Aug. 22, 2024
A
series
of
progress
has
been
made
in
the
field
antimicrobial
use
nanozymes
due
to
their
superior
stability
and
decreased
susceptibility
drug
resistance.
However,
catalytically
generated
reactive
oxygen
species
(ROS)
are
insufficient
for
coping
with
multidrug-resistant
organisms
(MDROs)
complex
wound
environments
low
targeting
ability
catalytic
activity.
To
address
this
problem,
chemically
stable
copper-gallic
acid-vancomycin
(CuGA-VAN)
nanoneedles
were
successfully
constructed
by
a
simple
approach
bacteria;
these
exhibit
OXD-like
GSH-px-like
dual
enzyme
activities
produce
ROS
induce
bacterial
cuproptosis-like
death,
thereby
eliminating
MDRO
infections.
The
results
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 25, 2024
Abstract
Traditional
hydrogels
often
face
issues
like
dehydration,
excessive
swelling,
and
poor
adhesion,
limiting
their
practical
applications.
This
study
presents
a
facile
universal
method
to
create
elastomer‐encapsulated
with
improved
water
retention,
non‐swelling,
enhanced
adhesion.
n‐Butyl
acrylate
(BA)
2,2,3,4,4,4‐hexafluorobutyl
methacrylate
(HFBMA)
are
utilized
as
the
“soft”
“hard”
monomers,
respectively,
in
situ
construct
elastomer
coatings
on
hydrogel
surface
through
surface‐confined
copolymerization.
The
resulting
transparent,
hydrophobic,
adhesive
coating
is
tightly
bound
surface,
conferring
upon
it
robust
defense
against
dehydration
swelling
various
media,
strong
adhesion
diverse
substrates
both
aerial
submerged
conditions.
Furthermore,
this
encapsulation
strategy
also
augments
mechanical
attributes
of
bulk
hydrogel,
including
its
tensile
properties
puncture
resistance,
applicable
wide
array
types
configurations.
Additionally,
applied
conductive
results
flexible
sensors
high
sensitivity,
reversible
resistance
change,
exceptional
sensing
stability,
significantly
durability
air
underwater
environments.
These
suggest
potential
applications
harsh
environments,
such
acoustic
detection
sonar
scanning
camouflage
for
submarines.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Electrotherapy
has
shown
considerable
potential
in
treating
chronic
wounds,
but
conventional
approaches
relying
on
bulky
external
power
supplies
and
mechanical
force
are
limited
their
clinical
utility.
This
study
introduces
an
autonomous,
moisture‐driven
flexible
electrogenerative
dressing
(AMFED)
that
overcomes
these
limitations.
The
AMFED
integrates
a
moist‐electric
generator
(MEG),
antibacterial
hydrogel
dressing,
concentric
molybdenum
(Mo)
electrodes
to
provide
self‐sustaining
electrical
supply
potent
activity
against
Staphylococcus
aureus
Escherichia
coli
.
MEG
harnesses
chemical
energy
from
moisture
produce
stable
direct
current
of
0.61
V
without
input,
delivering
this
therapeutic
stimulation
the
wound
site
through
Mo
electrodes.
facilitates
macrophage
polarization
toward
reparative
M2
phenotype
regulates
inflammatory
cytokines.
Moreover,
vivo
studies
suggest
group
significantly
enhances
healing,
with
approximate
41%
acceleration
compared
control
group.
Using
diabetic
mouse
model,
demonstrates
its
effectiveness
promoting
nerve
regulation,
epithelial
migration,
vasculogenesis.
These
findings
present
novel
efficient
platform
for
accelerating
healing.
National Science Review,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Hydrogel
bioadhesives,
when
applied
to
dysfunctional
tissues
substituting
the
epidermis
or
endothelium,
exhibit
compelling
characteristics
that
enable
revolutionary
diagnostic
and
therapeutic
procedures.
Despite
their
demonstrated
efficacy,
these
hydrogels
as
soft
implants
are
still
limited
by
improper
symmetric
surface
functions,
leading
postoperative
complications
disorders.
Janus
hydrogel
bioadhesives
with
unique
asymmetric
designs
have
thus
been
proposed
a
reliable
biocompatible
interface,
mimicking
structural
of
natural
biological
barriers.
In
this
comprehensive
review,
we
provide
guidelines
for
rational
design
covering
methods
chemistry
microstructure
engineering.
The
engineering
is
highlighted,
specifically
in
tuning
basal
facilitate
instant
robust
hydrogel-tissue
integration
modulating
apical
anti-adhesion,
anti-fouling,
anti-wear
barrier.
These
hold
great
potential
clinical
translation,
supporting
applications
including
hemostasis/tissue
sealing,
chronic
wound
management,
regenerative
medicine.
By
shedding
light
on
bioactive
interfaces,
review
paper
aims
inspire
further
research
overcome
current
obstacles
advancing
matter
next-generation
healthcare.
