Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113929 - 113929
Published: April 1, 2025
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 24327 - 24349
Published: Aug. 22, 2024
A series of progress has been made in the field antimicrobial use nanozymes due to their superior stability and decreased susceptibility drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) complex wound environments low targeting ability catalytic activity. To address this problem, chemically stable copper-gallic acid-vancomycin (CuGA-VAN) nanoneedles were successfully constructed by a simple approach bacteria; these exhibit OXD-like GSH-px-like dual enzyme activities produce ROS induce bacterial cuproptosis-like death, thereby eliminating MDRO infections. The results
Language: Английский
Citations
40
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 25, 2024
Abstract Traditional hydrogels often face issues like dehydration, excessive swelling, and poor adhesion, limiting their practical applications. This study presents a facile universal method to create elastomer‐encapsulated with improved water retention, non‐swelling, enhanced adhesion. n‐Butyl acrylate (BA) 2,2,3,4,4,4‐hexafluorobutyl methacrylate (HFBMA) are utilized as the “soft” “hard” monomers, respectively, in situ construct elastomer coatings on hydrogel surface through surface‐confined copolymerization. The resulting transparent, hydrophobic, adhesive coating is tightly bound surface, conferring upon it robust defense against dehydration swelling various media, strong adhesion diverse substrates both aerial submerged conditions. Furthermore, this encapsulation strategy also augments mechanical attributes of bulk hydrogel, including its tensile properties puncture resistance, applicable wide array types configurations. Additionally, applied conductive results flexible sensors high sensitivity, reversible resistance change, exceptional sensing stability, significantly durability air underwater environments. These suggest potential applications harsh environments, such acoustic detection sonar scanning camouflage for submarines.
Language: Английский
Citations
15
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154518 - 154518
Published: Aug. 5, 2024
Language: Английский
Citations
12
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122751 - 122751
Published: Sept. 15, 2024
Language: Английский
Citations
11
National Science Review, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 9, 2024
Hydrogel bioadhesives, when applied to dysfunctional tissues substituting the epidermis or endothelium, exhibit compelling characteristics that enable revolutionary diagnostic and therapeutic procedures. Despite their demonstrated efficacy, these hydrogels as soft implants are still limited by improper symmetric surface functions, leading postoperative complications disorders. Janus hydrogel bioadhesives with unique asymmetric designs have thus been proposed a reliable biocompatible interface, mimicking structural of natural biological barriers. In this comprehensive review, we provide guidelines for rational design covering methods chemistry microstructure engineering. The engineering is highlighted, specifically in tuning basal facilitate instant robust hydrogel-tissue integration modulating apical anti-adhesion, anti-fouling, anti-wear barrier. These hold great potential clinical translation, supporting applications including hemostasis/tissue sealing, chronic wound management, regenerative medicine. By shedding light on bioactive interfaces, review paper aims inspire further research overcome current obstacles advancing matter next-generation healthcare.
Language: Английский
Citations
10
European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113723 - 113723
Published: Jan. 1, 2025
Language: Английский
Citations
2
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Smart delivery materials that respond to electric fields attract interest across various fields, whereas systems enabling rapid, controllable, and safe capabilities remain essential. Based on the hypothesis of utilizing field manipulate inter‐component noncovalent bonds in materials, a hydrogel system is hereby reported capable achieving rapid guest release at low‐voltage region. This harnesses synergistic regulation field‐induced host‐guest electrostatic repulsion, alongside dynamic modulation H‐bond interactions within conductive hydrogel. Consequently, voltage 1.5 V influences multi‐component non‐covalent crosslinking, inducing reversible pore size enlargement, an accelerated yet controlled 39–48% 120 min V, with low‐threshold 0.5 V. enables molecules, including drugs, fluorescent probes, luminophores, underscoring universality strategy. Furthermore, electrical control device constructed from such blocks demonstrated, which performing “time‐specific” information encoding access. The mechanism relies physical processes, avoiding traditional redox reactions, thereby inspiring development efficient electrically responsive devices diverse functionalities, leveraging effect interactions.
Language: Английский
Citations
2
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Abstract Electrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited their clinical utility. This study introduces an autonomous, moisture‐driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist‐electric generator (MEG), antibacterial hydrogel dressing, concentric molybdenum (Mo) electrodes to provide self‐sustaining electrical supply potent activity against Staphylococcus aureus Escherichia coli . MEG harnesses chemical energy from moisture produce stable direct current of 0.61 V without input, delivering this therapeutic stimulation the wound site through Mo electrodes. facilitates macrophage polarization toward reparative M2 phenotype regulates inflammatory cytokines. Moreover, vivo studies suggest group significantly enhances healing, with approximate 41% acceleration compared control group. Using diabetic mouse model, demonstrates its effectiveness promoting nerve regulation, epithelial migration, vasculogenesis. These findings present novel efficient platform for accelerating healing.
Language: Английский
Citations
2
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract Electrical stimulation (ES) dressings have garnered considerable attention owing to their profound impact on chronic wound care, while the existing ES necessitate external power supply or intricate structures, posing potential safety risks and usage inconveniences. Herein, a safe, stable, simple, serviceable, self‐powered (5S) dressing composed of an electrospinning asymmetric nanofiber membrane with screen‐printed electrodes polyurethane foam is developed. The acts as due its electrical double‐layer effect during unidirectional exudate transfer, excellent water absorption retention properties effectively manages exudate. This 5S generates sustained low‐voltage direct current in situ at site creates favorable microenvironment for re‐epithelization. In vitro vivo studies indicate that this can significantly promote healing. Compared control group (on 7th day), collagen deposition treated increased by 15.9%, capillary density 90.6%, epidermal thickness 228.3%, resulting 23.6% enhancement healing rate. Consequently, presents highly sophisticated effective therapeutic approach accelerating
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140774 - 140774
Published: Feb. 10, 2025
Language: Английский
Citations
1