International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140820 - 140820
Published: Feb. 1, 2025
Language: Английский
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 1 - 17
Published: Feb. 12, 2025
Language: Английский
Citations
3
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)
Published: Jan. 29, 2024
The therapy of solid tumors is often hindered by the compact and rigid tumoral extracellular matrix (TECM). Precise reduction TECM hyaluronidase (HAase) in combination with nanotechnology promising for tumor therapeutics, yet remains an enormous challenge. Inspired treatment iron poisoning, here a remotely unwrapping strategy proposed metal-polyphenol-packaged HAase (named PPFH) sequentially injecting PPFH clinically used iron-chelator deferoxamine (DFO). situ dynamic disassembly can be triggered intravenously injected DFO, resulting release, reactivation, deep penetration encapsulated inside tumors. Such cost-effective delivery memorably improves subsequent photothermal photodynamic (PTT/PDT)-induced intratumoral infiltration cytotoxic T lymphocyte cells cross-talk between tumor-draining lymph nodes (TDLN), thereby decreasing immunosuppression optimizing tumoricidal immune response that efficiently protect mice from growth, metastasis, recurrence multiple mouse cancer models. Overall, this work presents proof-of-concept metal-polyphenol nanoparticles drug as well modulation immunosuppressive microenvironment.
Language: Английский
Citations
17
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
17
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)
Published: March 22, 2024
Abstract Osteosarcoma, a common invasive malignant bone disease, presents therapeutic challenges due to the persistent problem of incomplete resection during surgical treatment. This often results in postoperative tumor recurrence and metastasis, large‐scale defects are difficult self‐repair, seriously affecting patient health. In this study, dual‐ion doped organic‐inorganic composited SOH 1 (CP) injectable hydrogel system is successfully designed constructed. consists sericin protein grafted with hydrazide bonds, oxidized chondroitin sulfate, Se Mg co‐doped HAp nanorods, polydopamine‐coated CaO 2 nanospheres. The displays strong anti‐tumor activity its mild photothermal effects combined chemotherapeutic efficacy SeO 3 2− . Because degradation behavior matches repair cycle, including nutritional support skeleton products promote cell proliferation, positive regulation Ca 2+ , PO 4 3− released via inorganic nanoparticles differentiation, shows excellent defect efficacy. Importantly, achieves 100% inhibition after 18 days, while ensuring complete 12 weeks. Hence, system, which both high anti‐osteosarcoma properties, can serve as new tool for osteosarcoma‐related repair.
Language: Английский
Citations
14
ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23727 - 23740
Published: Aug. 19, 2024
The treatment of triple-negative breast cancer (TNBC) faces challenges due to its limited immune response and weak tumor immunogenicity. A collaborative strategy involves combining the activation pyroptosis stimulator interferon genes (STING) pathway enhance immunogenicity fortify antitumor response, which may improve therapeutic outcomes in TNBC. In this study, we report fabrication a zinc-phenolic nanocapsule (RMP@Cap), is loaded with mitoxantrone (MTO) anti-PD-L1 antibodies (aPD-L1) coated erythrocyte membrane, for TNBC immunotherapy. delivery RMP@Cap can induce cell and, therefore, trigger release mitochondrial DNA, further combines zinc agonists intensify STING activation, resulting cascade amplification effect on tumors. Additionally, incorporation aPD-L1 into relieves inhibitory cells recruited cytotoxic T cells, thereby improving tumor-killing capacity. Furthermore, camouflaged membrane coating enables nanocapsules achieve prolonged
Language: Английский
Citations
14
Materials Science and Engineering R Reports, Journal Year: 2024, Volume and Issue: 160, P. 100821 - 100821
Published: July 4, 2024
Language: Английский
Citations
12
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1115 - 1129
Published: Nov. 9, 2024
Language: Английский
Citations
10
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 11, 2025
Background STING is a core signaling hub molecule in the innate immune system, involved various diseases, including infectious autoimmune tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential anti-tumor anti-infective therapies, with agonists emerging as promising approach cancer immunotherapy recent years. This study identifies research trends directions field by collecting analyzing relevant literature. Methods A total of 527 publications regarding 107 about inhibitors were retrieved from WOS Core Collection database. Bibliometric information was extracted CiteSpace VOSviewer software for visualization. Results It shows that on both burgeoning rapidly. The United States China are leading contributors this field. Application primarily focuses immunotherapy, while target inflammation, particularly neuroinflammation acute lung injury. Conclusion Current emphasizes optimizing permeability, efficacy, safety, nanotechnology lipid nanoparticles being prominent delivery techniques. Future expected to focus drug development clinical applications. comprehensive bibliometric analysis provides insights guide further investigation agonist/inhibitor.
Language: Английский
Citations
2
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: 8(3), P. 1749 - 1784
Published: Feb. 18, 2025
Lenvatinib (LEN), a tyrosine kinase inhibitor, has emerged as promising therapeutic agent for various solid tumors. Nevertheless, number of constraints, including diminished bioavailability, incapacity to elicit localized inflammation, and inability selectively accumulate at the tumor site, may impede comprehensive exploitation its versatile inhibitory capabilities. In order achieve targeted delivery LEN while also reducing high dose used in conventional therapeutics, nanoformulation approaches can be adopted. The integration into nanoformulations, such nanoparticles, nanocrystals, density lipoproteins (HDLs), liposomes, micelles, is discussed, highlighting advantages these innovative comparative manner; however, given that current methods synthesis employ toxic organic solvents chemicals, there an imperative need exploring alternative, environmentally friendly approaches. multifaceted effects nanocarriers have rendered them profoundly applicable within biomedical domain, serving instrumental entities capacities vehicles drug genetic material, diagnostic agents, facilitators photothermal therapy, radiotherapy. However, scalability nanotechnological methodologies must rigorously investigated addressed refine mechanisms. This endeavor offers prospects revolutionizing strategies cancer thereby laying foundation future research scale-up techniques pursuit more effective less therapies cancer.
Language: Английский
Citations
2
Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(11), P. 1623 - 1642
Published: Nov. 2, 2023
Tumors pose a significant global economic and health burden, with conventional cancer treatments lacking tumor specificity, leading to limited efficiency undesirable side effects. Targeted therapy is imminent. Tumor cells produce lactate hydrogen ions (H
Language: Английский
Citations
22