Abstract
Fluorescence
molecular
imaging
(FMI),
a
promising
in
vivo
non‐invasive
optical
technology,
has
high
sensitivity,
specificity,
and
spatio‐temporal
resolution.
Owing
to
its
further
advantages
of
low
cost
no
radiation,
FMI
been
extensively
employed
the
diagnosis
treatment
tumors,
vascular
system,
guided
delivery
drugs.
Nonetheless,
affected
by
strong
photon
absorption
scattering,
faces
two
major
challenges:
limited
tissue
penetration
depth
complicated
tomography
reconstruction.
This
review
clarifies
both
challenges
for
first
time
summarizing
advances
near‐infrared
region
II
(NIR‐II)
fluorescence
(FMT).
In
detail,
NIR‐II
conditions,
representative
probes,
FMT
systems,
reconstruction
algorithms
are
reviewed.
The
can
achieve
deeper
higher
resolution,
which
facilitate
more
accurate
FMT.
And
turn,
precise
will
promote
development
application
imaging.
Additionally,
future
deeply
analyzed,
potential
improvement
avenues
discussed.
strengthening
methodological
investigation
is
proposed
impel
FMI,
ultimately
providing
effective
tools
biomedical
field.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 29, 2024
The
therapy
of
solid
tumors
is
often
hindered
by
the
compact
and
rigid
tumoral
extracellular
matrix
(TECM).
Precise
reduction
TECM
hyaluronidase
(HAase)
in
combination
with
nanotechnology
promising
for
tumor
therapeutics,
yet
remains
an
enormous
challenge.
Inspired
treatment
iron
poisoning,
here
a
remotely
unwrapping
strategy
proposed
metal-polyphenol-packaged
HAase
(named
PPFH)
sequentially
injecting
PPFH
clinically
used
iron-chelator
deferoxamine
(DFO).
situ
dynamic
disassembly
can
be
triggered
intravenously
injected
DFO,
resulting
release,
reactivation,
deep
penetration
encapsulated
inside
tumors.
Such
cost-effective
delivery
memorably
improves
subsequent
photothermal
photodynamic
(PTT/PDT)-induced
intratumoral
infiltration
cytotoxic
T
lymphocyte
cells
cross-talk
between
tumor-draining
lymph
nodes
(TDLN),
thereby
decreasing
immunosuppression
optimizing
tumoricidal
immune
response
that
efficiently
protect
mice
from
growth,
metastasis,
recurrence
multiple
mouse
cancer
models.
Overall,
this
work
presents
proof-of-concept
metal-polyphenol
nanoparticles
drug
as
well
modulation
immunosuppressive
microenvironment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(34), P. 23727 - 23740
Published: Aug. 19, 2024
The
treatment
of
triple-negative
breast
cancer
(TNBC)
faces
challenges
due
to
its
limited
immune
response
and
weak
tumor
immunogenicity.
A
collaborative
strategy
involves
combining
the
activation
pyroptosis
stimulator
interferon
genes
(STING)
pathway
enhance
immunogenicity
fortify
antitumor
response,
which
may
improve
therapeutic
outcomes
in
TNBC.
In
this
study,
we
report
fabrication
a
zinc-phenolic
nanocapsule
(RMP@Cap),
is
loaded
with
mitoxantrone
(MTO)
anti-PD-L1
antibodies
(aPD-L1)
coated
erythrocyte
membrane,
for
TNBC
immunotherapy.
delivery
RMP@Cap
can
induce
cell
and,
therefore,
trigger
release
mitochondrial
DNA,
further
combines
zinc
agonists
intensify
STING
activation,
resulting
cascade
amplification
effect
on
tumors.
Additionally,
incorporation
aPD-L1
into
relieves
inhibitory
cells
recruited
cytotoxic
T
cells,
thereby
improving
tumor-killing
capacity.
Furthermore,
camouflaged
membrane
coating
enables
nanocapsules
achieve
prolonged
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(30)
Published: March 22, 2024
Abstract
Osteosarcoma,
a
common
invasive
malignant
bone
disease,
presents
therapeutic
challenges
due
to
the
persistent
problem
of
incomplete
resection
during
surgical
treatment.
This
often
results
in
postoperative
tumor
recurrence
and
metastasis,
large‐scale
defects
are
difficult
self‐repair,
seriously
affecting
patient
health.
In
this
study,
dual‐ion
doped
organic‐inorganic
composited
SOH
1
(CP)
injectable
hydrogel
system
is
successfully
designed
constructed.
consists
sericin
protein
grafted
with
hydrazide
bonds,
oxidized
chondroitin
sulfate,
Se
Mg
co‐doped
HAp
nanorods,
polydopamine‐coated
CaO
2
nanospheres.
The
displays
strong
anti‐tumor
activity
its
mild
photothermal
effects
combined
chemotherapeutic
efficacy
SeO
3
2−
.
Because
degradation
behavior
matches
repair
cycle,
including
nutritional
support
skeleton
products
promote
cell
proliferation,
positive
regulation
Ca
2+
,
PO
4
3−
released
via
inorganic
nanoparticles
differentiation,
shows
excellent
defect
efficacy.
Importantly,
achieves
100%
inhibition
after
18
days,
while
ensuring
complete
12
weeks.
Hence,
system,
which
both
high
anti‐osteosarcoma
properties,
can
serve
as
new
tool
for
osteosarcoma‐related
repair.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(34)
Published: April 29, 2024
Abstract
Photothermal
immunotherapy
represents
an
effective
approach
for
eliminating
both
local
and
metastatic
tumors
through
priming
of
the
tumor‐specific
immune
response.
Cytosolic
delivery
double‐stranded
DNA
via
pH‐responsive
vehicles
is
recently
verified
to
activate
cyclic
guanosine
monophosphate–adenosine
monophosphate
(GMP‐AMP)
synthase‐stimulator
interferon
genes
(cGAS‐STING)
pathway,
which
robust
in
activating
innate
adaptive
antitumor
immunity.
Herein,
multifunctional
phototheranostics
with
excellent
photothermal
conversion
capacity,
second
near‐infrared
(NIR‐II)
fluorescence,
cGAS‐STING
capacity
are
prepared
by
encapsulating
fish
testis
conjugated
boron
dipyrromethene
tetramers
poly(lactic‐co‐glycolic
acid)
poly(ethylene
glycol)‐b‐poly(lactic‐co‐glycolic
a
CaCO
3
‐assisted
double
emulsion
method.
The
obtained
(coined
DB
4
CaP
NPs)
after
intravenous
administration
gradually
accumulate
tumor
regions,
as
shown
NIR‐II
fluorescence
imaging.
Together
915
nm
laser
exposure,
primary
mice
treated
NPs
could
be
effectively
eradicated,
complete
response
83.3%.
Furthermore,
such
synergize
anti‐programmed
cell
death
protein
1
suppress
growth
distant
unirradiated
rechallenged
This
study
highlights
promising
strategy
eradicating
tumors,
particularly
invisible
unresectable
micronodules,
imaging‐guided
immunotherapy.
Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
ABSTRACT
Chitosan
(CS)‐based
drug
delivery
systems
often
face
challenges
in
obtaining
clinical
approval.
Enhancing
the
binding
affinity
of
CS‐based
carriers
to
target
cells,
such
as
tumor
is
crucial
for
their
translation
from
bench
bedside.
Strategies
like
crosslinking
(NHS‐disulfide‐NHS)
and
utilizing
materials
albumin
have
proven
effective
strengthening
interactions
between
nanoparticles
thereby
enhancing
cellular
uptake
(cellular
avidity).
This
study
presents
a
novel
approach
using
crosslinked
CS
loaded
with
doxorubicin,
featuring
reduction‐responsive
release
coating.
The
albumin‐coated
chitosan
(ACCC)
was
assembled
via
reaction
amino
CS/albumin
NHS‐disulfide‐NHS.
resulting
ACCC
nanoparticle
micelles
demonstrate
enhanced
stability
micelles.
hybrid
network
ensures
while
providing
ample
space
loading
achieves
through
disulfide
bond
crosslinking.
Moreover,
proposed
system
possesses
excellent
biocompatibility.
Compared
uncoated
micelles,
exhibit
potent
cytotoxicity
against
particularly
reducing
environment.
Fluorescence
imaging
flow
cytometry
analyses
confirm
conferred
by
These
findings
underscore
potential
improving
cell
adhesion
anti‐tumor
efficacy,
thus
offering
promising
prospects
translational
medicine
delivery.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 11, 2025
Background
STING
is
a
core
signaling
hub
molecule
in
the
innate
immune
system,
involved
various
diseases,
including
infectious
autoimmune
tumors,
aging,
organ
fibrosis,
and
neurodegenerative
diseases.
Its
activation
has
shown
great
potential
anti-tumor
anti-infective
therapies,
with
agonists
emerging
as
promising
approach
cancer
immunotherapy
recent
years.
This
study
identifies
research
trends
directions
field
by
collecting
analyzing
relevant
literature.
Methods
A
total
of
527
publications
regarding
107
about
inhibitors
were
retrieved
from
WOS
Core
Collection
database.
Bibliometric
information
was
extracted
CiteSpace
VOSviewer
software
for
visualization.
Results
It
shows
that
on
both
burgeoning
rapidly.
The
United
States
China
are
leading
contributors
this
field.
Application
primarily
focuses
immunotherapy,
while
target
inflammation,
particularly
neuroinflammation
acute
lung
injury.
Conclusion
Current
emphasizes
optimizing
permeability,
efficacy,
safety,
nanotechnology
lipid
nanoparticles
being
prominent
delivery
techniques.
Future
expected
to
focus
drug
development
clinical
applications.
comprehensive
bibliometric
analysis
provides
insights
guide
further
investigation
agonist/inhibitor.
