Enhanced Bacterial Cuproptosis‐Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: 11(19)

Published: March 13, 2024

Abstract A recently emerging cell death pathway, known as copper‐induced death, has demonstrated significant potential for treating infections. Existing research suggests that cells utilizing aerobic respiration, opposed to those reliant on glycolysis, exhibit greater sensitivity death. Herein, a MnO 2 ‐loaded copper metal–organic frameworks platform is developed denoted MCM, enhance bacterial cuproptosis‐like via the remodeling of respiratory metabolism. The reversal hypoxic microenvironments induced cascade responses, encompassing reactivation suppressed immune responses and promotion osteogenesis angiogenesis. Initially, MCM catalyzed O production, alleviating hypoxia within biofilm inducing transition in respiration mode from glycolysis respiration. Subsequently, sensitized bacteria, characterized by enhanced tricarboxylic acid cycle activity, underwent owing increased concentrations aggregated intracellular dihydrolipoamide S‐acetyltransferase (DLAT). disruption also stimulated dendritic macrophages, thereby strengthening their antimicrobial activity through chemotaxis phagocytosis. Moreover, nutritional effects elements, coupled with alleviation, synergistically facilitated regeneration bones blood vessels. Overall, reshaping infection microenvironment presents promising avenue eradicating biofilms.

Language: Английский

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Copper-based nanomaterials for biomedical applications

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149040 - 149040

Published: Jan. 23, 2024

Among metal-based nanomaterials, Copper-based nanomaterials (Cu-BNMs) have become a research hotspot in the biomedical field due to their good biocompatibility and unique properties. However, there are fewer systematic summaries of copper-based especially synthesis Cu-BNMs. As for applications, Cu-BNMs been widely used fields antimicrobial, imaging, therapeutics, showing excellent promising Herein, this review firstly introduces classification various methods synthesizing through both top-down bottom-up types. Then, applications within three tumor therapy classified summarized. Finally, challenges faced application future development c discussed provide basic information illustrations

Language: Английский

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Piezoelectric‐Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Strategies of manipulating redox signaling molecules to inhibit or activate immune signals have revolutionized therapeutics involving reactive oxygen species (ROS). However, certain diseases with dual resistance barriers the attacks by both ROS and cells, such as bacterial biofilm infections medical implants, are difficult eradicate a single exogenous oxidative stimulus due diversity complexity involved. Here, this work demonstrates that metal‐organic framework (MOF) nanoparticles capable disrupting ROS‐defense system can dismantle induce potent antimicrobial responses in mouse model surgical implant infection simultaneously modulating homeostasis initiating neutrophil N1 polarization microenvironment. Mechanistically, piezoelectrically enhanced MOF triggers production tilting band structure acts synergistically aurintricarboxylic acid loaded within MOF, which inhibits activity cystathionine γ‐cleaving enzyme. This leads disruption antigen exposure through homeostatic imbalance synergistic activation signals. Thus, study provides an alternative but promising strategy for treatment antibiotic‐resistant infections.

Language: Английский

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ZnO‐CuS/F127 Hydrogels with Multienzyme Properties for Implant‐Related Infection Therapy by Inhibiting Bacterial Arginine Biosynthesis and Promoting Tissue Repair

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Implant‐related infections are characterized by the formation of bacterial biofilms. Current treatments have various drawbacks. Nanozymes with enzyme‐like activity can produce highly toxic substances to kill bacteria and remove biofilms without inducing drug resistance. However, it is difficult for current monometallic nanozymes function well in complex biofilm environments. Therefore, development multimetallic efficient multienzyme activities crucial. In present study, bimetallic nanozyme, ZnO‐CuS nanoflowers peroxidase (POD), glutathione oxidase (GSH‐Px), catalase (CAT) successfully synthesized via calcination loaded into F127 hydrogels treatment implant‐related infections. The ability bind key antimicrobial activity. addition, H 2 O disrupt metabolism MRSA , including arginine synthesis, nucleotide excision repair, energy metabolism, protein synthesis. ZnO‐CuS/F127 hydrogel combination has been demonstrated be effective clearing infection facilitating switch M1 macrophages M2‐repairative phenotype implant mice. Furthermore, favorable biosafety, their toxicity negligible. provided a promising biomedical strategy healing infections, highlighting potential clinical applications.

Language: Английский

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Ultrasound-assisted activation of PAW residual radicals in the concurrent elimination of ARB and ARGs: Process efficiency, mechanism and implication

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148627 - 148627

Published: Jan. 9, 2024

Language: Английский

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