The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 743 - 743

Published: March 27, 2024

Mesenchymal stem cells (MSCs) have been recognized as a cell therapy with the potential to promote skin healing. MSCs, their multipotent differentiation ability, can generate various related wound healing, such dermal fibroblasts (DFs), endothelial cells, and keratinocytes. In addition, MSCs neovascularization, cellular regeneration, tissue healing through mechanisms including paracrine autocrine signaling. Due these characteristics, extensively studied in context of burn chronic repair. Furthermore, during investigation unique roles aging scarless also discovered. this review, we summarize by which discuss recent findings from preclinical clinical studies. We explore strategies enhance therapeutic effects MSCs. Moreover, emerging trend combining engineering techniques, leveraging advantages materials, biodegradable scaffolds hydrogels, repair capacity Additionally, highlight using characteristics cell-free therapies future direction cell-based treatments, further demonstrating regenerative aesthetic applications regeneration.

Language: Английский

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Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 6, 2024

Abstract Adipose-derived stem cells (ADSCs) are a subset of mesenchymal (MSCs) isolated from adipose tissue. They possess remarkable properties, including multipotency, self-renewal, and easy clinical availability. ADSCs also capable promoting tissue regeneration through the secretion various cytokines, factors, extracellular vesicles (EVs). ADSC-derived EVs (ADSC-EVs) act as intercellular signaling mediators that encapsulate range biomolecules. These have been found to mediate therapeutic activities donor by proliferation migration effector cells, facilitating angiogenesis, modulating immunity, performing other specific functions in different tissues. Compared themselves, ADSC-EVs offer advantages such fewer safety concerns more convenient transportation storage for application. As result, these received significant attention cell-free agents with potential future application regenerative medicine. In this review, we focus on recent research progress regarding medical use across conditions, wound healing, chronic limb ischemia, myocardial infarction, diabetic nephropathy, fat graft survival, bone regeneration, cartilage tendinopathy tendon peripheral nerve acute lung injury, among others. We discuss underlying mechanisms responsible inducing effects. believe deciphering biological effects, associated will provide foundation developing novel approach Graphical

Language: Английский

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Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30

Published: April 23, 2024

Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.

Language: Английский

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Engineered exosomes and composite biomaterials for tissue regeneration

Theranostics, Journal Year: 2024, Volume and Issue: 14(5), P. 2099 - 2126

Published: Jan. 1, 2024

Exosomes, which are small vesicles enclosed by a lipid bilayer and released many cell types, widely dispersed have garnered increased attention in the field of regenerative medicine due to their ability serve as indicators diseases agents with therapeutic potential. Exosomes play crucial role mediating intercellular communication through transfer biomolecules, including proteins, lipids, RNA, other molecular constituents, between cells. The targeted transport proteins nucleic acids specific cells has potential enhance or impair biological functions. applications, they can be used alone combination approaches. examination unique attributes functions these factors emerged prominent study realm biomedical research. This manuscript summarizes origins properties exosomes, structural, biological, physical, chemical aspects. paper offers complete recent progress tissue repair medicine, emphasizing possible implications methods forthcoming regeneration attempts.

Language: Английский

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Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2356 - 2356

Published: Feb. 16, 2024

Adipose tissue (AT) is a large and important energy storage organ as well an endocrine with critical role in many processes. Additionally, AT enormous easily accessible source of multipotent cell types used our day for all regeneration. The ability adipose-derived stem cells (ADSCs) to differentiate into other cells, such endothelial (ECs), vascular smooth muscle or cardiomyocytes, engineering order promote/stimulate the process angiogenesis. Being key future successful clinical applications, functional networks engineered are targeted by numerous vivo ex studies. article reviews angiogenic potential ADSCs explores their capacity field (TE).

Language: Английский

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Enhanced physiochemical, antibacterial, and hemostatic performance of collagen-quaternized chitosan-graphene oxide sponges for promoting infectious wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131277 - 131277

Published: March 31, 2024

Bacteria-infected wound healing has attracted widespread attention in biomedical engineering. Wound dressing is a potential strategy for repairing infectious wounds. However, the development of with appropriate physiochemical, antibacterial, and hemostatic properties, remains challenging. Hence, there motivation to develop new synthetic dressings improve bacteria-infected healing. Here, we fabricate biocompatible sponge through covalent crosslinking collagen (Col), quaternized chitosan (QCS), graphene oxide (GO). The resulting Col-QCS-GO shows an elastic modulus 1.93-fold higher than Col due enhanced degree by GO incorporation. Moreover, fabricated favorable porosity (84.30 ± 3.12 %), water absorption/retention (2658.0 113.4 %/1114.0 65.7 hemostasis capacities (blood loss <50.0 mg). Furthermore, antibacterial property under near-infrared (NIR) irradiation significantly (the inhibition rates are 99.9 % S. aureus E. coli) inherent properties QCS photothermal capabilities GO. Finally, Col-QCS-GO+NIR exhibits lowest percentage area (9.05 1.42 %) at day 14 compared control group (31.61 1.76 %). This study provides insights developing innovative sponges

Language: Английский

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Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5916 - 5916

Published: May 29, 2024

Adipose-derived stem cells (ADSCs) are mesenchymal with a great potential for self-renewal and differentiation. Exosomes derived from ADSCs (ADSC-exos) can imitate their functions, carrying cargoes of bioactive molecules that may affect specific cellular targets signaling processes. Recent evidence has shown ADSC-exos mediate tissue regeneration through the regulation inflammatory response, enhancement cell proliferation, induction angiogenesis. At same time, they promote wound healing as well remodeling extracellular matrix. In combination scaffolds, present future cell-free therapies promising adjuncts to reconstructive surgery diverse tissue-specific functions minimal adverse effects. this review, we address main characteristics functional properties in explore most recent clinical application healing, musculoskeletal regeneration, dermatology, plastic engineering.

Language: Английский

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Extracellular vesicles in skin health, diseases, and aging

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3)

Published: May 29, 2024

Abstract The skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. dynamic interactions between various cell types are essential for homeostasis function. Emerging research has unveiled significant role of extracellular vesicles (EVs) key mediators communication in regulating many aspects physiological pathological processes. In this review, we provide overview recent advances understanding roles EVs health, aging, diseases, discuss natural engineered disease treatment along potential challenges. burgeoning area may expand new therapeutic approaches disorders open avenues personalized skincare treatments.

Language: Английский

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Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design materials development of electrospinning nanofiber (ENPs), which evolved from single‐needle multi‐needle creating 3D ENPs, diversify their application including drugs/cell/growth factors release, anti‐bacterial anti‐inflammatory, hemostasis, wound healing, Herein, multifunctional ENPs with bioactive polymer fabricated via in terms novel material design, construction various structures, requirements different regeneration are reviewed. Furthermore, this review delves into advancements facilitated by highlighting effectiveness versatility across types such as bone, cartilage, tendons, cardiac tissue, nerves. The discussion comprehensively addresses ongoing challenges selection, biodegradation mechanisms, bioactivation strategies, techniques specific applications. Moreover, outlines potential future research avenues aimed at enhancing ENPs‐based approaches engineering. This in‐depth analysis aims provide nuanced insights technical recommendations propel field forward

Language: Английский

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Asymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 19, 2024

Abstract Severe tissue injuries pose a significant risk to human health. Conventional wound dressings fall short in achieving effective regeneration, resulting suboptimal postoperative healing outcomes. In this study, an asymmetric adhesive dressing (marked as SIS/PAA/LAP) was developed, originating from acrylate acid (AA) solution with laponite (LAP) nanoparticles polymerization and photo-crosslinked on the decellularized extracellular matrix small intestinal submucosa (SIS) patch. Extensive studies demonstrated that SIS/PAA/LAP exhibited higher adhesion strength (~ 33 kPa) burst 22 compared conventional like Tegaderm products. Importantly, it maintained favorable cell viability robust angiogenic capacity. animal models of full-thickness skin rats Bama miniature pigs, could be precisely applied sites. By accelerating formation vascularization, displayed superior repair This asymmetrically SIS-based patch would hold promising applications field dressings.

Language: Английский

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