Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Platelet‐rich
plasma
(PRP)
is
characterized
by
elevated
concentrations
of
growth
factors
that
facilitate
bone
repair.
Nonetheless,
the
effective
integration
PRP
with
implants
and
sustained
release
its
active
constituents
pose
significant
challenges.
In
this
study,
thrombin
grafted
onto
surface
polyetheretherketone
(PEEK)
via
an
N,N'‐Disuccinimidyl
Carbonate
(DSC)
linker
retained
enzymatic
activity
enables
controlled
activation
self‐assembly,
resulting
in
formation
a
functional
bio‐gel
layer.
The
optimal
concentration
to
be
100
U/
mL
−1
determined,
at
which
point
both
grafting
amount
reaches
their
peak,
no
further
increases
observed
higher
concentrations.
solutions
varying
platelet
enrichment
ratios
are
subsequently
activated
on
thrombin‐grafted
PEEK
surface,
yielding
self‐assembled
bio‐gels
capable
factor
for
up
16
days.
thrombin‐activated
not
only
enhances
vitro
cell
adhesion,
proliferation,
osteogenic
differentiation,
vascularization
specific
polarization
macrophages,
but
also
effectively
facilitates
vivo
angiogenesis,
immunomodulation
dose‐dependent
manner.
Consequently,
gel
presents
promising
strategy
biological
functionalization
orthopedic
applications.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 743 - 743
Published: March 27, 2024
Mesenchymal
stem
cells
(MSCs)
have
been
recognized
as
a
cell
therapy
with
the
potential
to
promote
skin
healing.
MSCs,
their
multipotent
differentiation
ability,
can
generate
various
related
wound
healing,
such
dermal
fibroblasts
(DFs),
endothelial
cells,
and
keratinocytes.
In
addition,
MSCs
neovascularization,
cellular
regeneration,
tissue
healing
through
mechanisms
including
paracrine
autocrine
signaling.
Due
these
characteristics,
extensively
studied
in
context
of
burn
chronic
repair.
Furthermore,
during
investigation
unique
roles
aging
scarless
also
discovered.
this
review,
we
summarize
by
which
discuss
recent
findings
from
preclinical
clinical
studies.
We
explore
strategies
enhance
therapeutic
effects
MSCs.
Moreover,
emerging
trend
combining
engineering
techniques,
leveraging
advantages
materials,
biodegradable
scaffolds
hydrogels,
repair
capacity
Additionally,
highlight
using
characteristics
cell-free
therapies
future
direction
cell-based
treatments,
further
demonstrating
regenerative
aesthetic
applications
regeneration.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 6, 2024
Abstract
Adipose-derived
stem
cells
(ADSCs)
are
a
subset
of
mesenchymal
(MSCs)
isolated
from
adipose
tissue.
They
possess
remarkable
properties,
including
multipotency,
self-renewal,
and
easy
clinical
availability.
ADSCs
also
capable
promoting
tissue
regeneration
through
the
secretion
various
cytokines,
factors,
extracellular
vesicles
(EVs).
ADSC-derived
EVs
(ADSC-EVs)
act
as
intercellular
signaling
mediators
that
encapsulate
range
biomolecules.
These
have
been
found
to
mediate
therapeutic
activities
donor
by
proliferation
migration
effector
cells,
facilitating
angiogenesis,
modulating
immunity,
performing
other
specific
functions
in
different
tissues.
Compared
themselves,
ADSC-EVs
offer
advantages
such
fewer
safety
concerns
more
convenient
transportation
storage
for
application.
As
result,
these
received
significant
attention
cell-free
agents
with
potential
future
application
regenerative
medicine.
In
this
review,
we
focus
on
recent
research
progress
regarding
medical
use
across
conditions,
wound
healing,
chronic
limb
ischemia,
myocardial
infarction,
diabetic
nephropathy,
fat
graft
survival,
bone
regeneration,
cartilage
tendinopathy
tendon
peripheral
nerve
acute
lung
injury,
among
others.
We
discuss
underlying
mechanisms
responsible
inducing
effects.
believe
deciphering
biological
effects,
associated
will
provide
foundation
developing
novel
approach
Graphical
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2099 - 2126
Published: Jan. 1, 2024
Exosomes,
which
are
small
vesicles
enclosed
by
a
lipid
bilayer
and
released
many
cell
types,
widely
dispersed
have
garnered
increased
attention
in
the
field
of
regenerative
medicine
due
to
their
ability
serve
as
indicators
diseases
agents
with
therapeutic
potential.
Exosomes
play
crucial
role
mediating
intercellular
communication
through
transfer
biomolecules,
including
proteins,
lipids,
RNA,
other
molecular
constituents,
between
cells.
The
targeted
transport
proteins
nucleic
acids
specific
cells
has
potential
enhance
or
impair
biological
functions.
applications,
they
can
be
used
alone
combination
approaches.
examination
unique
attributes
functions
these
factors
emerged
prominent
study
realm
biomedical
research.
This
manuscript
summarizes
origins
properties
exosomes,
structural,
biological,
physical,
chemical
aspects.
paper
offers
complete
recent
progress
tissue
repair
medicine,
emphasizing
possible
implications
methods
forthcoming
regeneration
attempts.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2356 - 2356
Published: Feb. 16, 2024
Adipose
tissue
(AT)
is
a
large
and
important
energy
storage
organ
as
well
an
endocrine
with
critical
role
in
many
processes.
Additionally,
AT
enormous
easily
accessible
source
of
multipotent
cell
types
used
our
day
for
all
regeneration.
The
ability
adipose-derived
stem
cells
(ADSCs)
to
differentiate
into
other
cells,
such
endothelial
(ECs),
vascular
smooth
muscle
or
cardiomyocytes,
engineering
order
promote/stimulate
the
process
angiogenesis.
Being
key
future
successful
clinical
applications,
functional
networks
engineered
are
targeted
by
numerous
vivo
ex
studies.
article
reviews
angiogenic
potential
ADSCs
explores
their
capacity
field
(TE).
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 18, 2025
Stem
cell-derived
extracellular
vesicles
(EVs)
have
emerged
as
a
safe
and
potent
alternative
to
regenerative
medicine
in
recent
decades.
Furthermore,
the
adjustment
of
EV
functions
has
been
recently
enabled
by
certain
stem
cell
preconditioning
methods,
providing
an
exceptional
opportunity
enhance
therapeutic
potential
or
confer
additional
EVs.
In
this
review,
we
discuss
progress
functionalized
EVs,
based
on
preconditioning,
for
treating
various
organ
systems,
such
musculoskeletal
system,
nervous
integumentary
cardiovascular
renal
respiratory
system.
Additionally,
summarize
expected
outcomes
methods
cells
their
With
progress,
suggest
considerations
future
directions
developing
personalized
preconditioned
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5916 - 5916
Published: May 29, 2024
Adipose-derived
stem
cells
(ADSCs)
are
mesenchymal
with
a
great
potential
for
self-renewal
and
differentiation.
Exosomes
derived
from
ADSCs
(ADSC-exos)
can
imitate
their
functions,
carrying
cargoes
of
bioactive
molecules
that
may
affect
specific
cellular
targets
signaling
processes.
Recent
evidence
has
shown
ADSC-exos
mediate
tissue
regeneration
through
the
regulation
inflammatory
response,
enhancement
cell
proliferation,
induction
angiogenesis.
At
same
time,
they
promote
wound
healing
as
well
remodeling
extracellular
matrix.
In
combination
scaffolds,
present
future
cell-free
therapies
promising
adjuncts
to
reconstructive
surgery
diverse
tissue-specific
functions
minimal
adverse
effects.
this
review,
we
address
main
characteristics
functional
properties
in
explore
most
recent
clinical
application
healing,
musculoskeletal
regeneration,
dermatology,
plastic
engineering.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
266, P. 131277 - 131277
Published: March 31, 2024
Bacteria-infected
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
Wound
dressing
is
a
potential
strategy
for
repairing
infectious
wounds.
However,
the
development
of
with
appropriate
physiochemical,
antibacterial,
and
hemostatic
properties,
remains
challenging.
Hence,
there
motivation
to
develop
new
synthetic
dressings
improve
bacteria-infected
healing.
Here,
we
fabricate
biocompatible
sponge
through
covalent
crosslinking
collagen
(Col),
quaternized
chitosan
(QCS),
graphene
oxide
(GO).
The
resulting
Col-QCS-GO
shows
an
elastic
modulus
1.93-fold
higher
than
Col
due
enhanced
degree
by
GO
incorporation.
Moreover,
fabricated
favorable
porosity
(84.30
±
3.12
%),
water
absorption/retention
(2658.0
113.4
%/1114.0
65.7
hemostasis
capacities
(blood
loss
<50.0
mg).
Furthermore,
antibacterial
property
under
near-infrared
(NIR)
irradiation
significantly
(the
inhibition
rates
are
99.9
%
S.
aureus
E.
coli)
inherent
properties
QCS
photothermal
capabilities
GO.
Finally,
Col-QCS-GO+NIR
exhibits
lowest
percentage
area
(9.05
1.42
%)
at
day
14
compared
control
group
(31.61
1.76
%).
This
study
provides
insights
developing
innovative
sponges
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: May 29, 2024
Abstract
The
skin
interfaces
with
the
external
environment,
acting
as
both
a
physical
barrier
and
an
immunologic
defense.
dynamic
interactions
between
various
cell
types
are
essential
for
homeostasis
function.
Emerging
research
has
unveiled
significant
role
of
extracellular
vesicles
(EVs)
key
mediators
communication
in
regulating
many
aspects
physiological
pathological
processes.
In
this
review,
we
provide
overview
recent
advances
understanding
roles
EVs
health,
aging,
diseases,
discuss
natural
engineered
disease
treatment
along
potential
challenges.
burgeoning
area
may
expand
new
therapeutic
approaches
disorders
open
avenues
personalized
skincare
treatments.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
