Nano Research, Journal Year: 2024, Volume and Issue: 17(6), P. 4737 - 4743
Published: Jan. 25, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)
Published: Jan. 4, 2024
Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.
Language: Английский
Citations
59
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216090 - 216090
Published: July 30, 2024
Language: Английский
Citations
32
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215797 - 215797
Published: April 4, 2024
Language: Английский
Citations
19
ACS Nano, Journal Year: 2024, Volume and Issue: 18(25), P. 16113 - 16125
Published: June 10, 2024
Urinary extracellular vesicles (uEVs) are regarded as highly promising liquid-biopsy biomarkers for the early diagnosis and prognosis of bladder cancer (BC). However, detection uEVs remains technically challenging owing to their huge heterogeneity ultralow abundance in real samples. We herein present a choline phosphate-grafted platinum nanozyme (Pt@CP) that acts universal EV probe construction high-throughput high-sensitivity immunoassay, which allowed multiplex profiling uEV protein markers BC detection. With Pt@CP-based immunoassays, three (MUC-1, CCDC25, GLUT1) were identified BC, by cases (n = 48), cystitis patients 27), healthy donors 24) discriminated with high clinical sensitivity specificity (area under curve 98.3%). For 9) after surgery, immunoassay could report postoperative residual tumor cannot be observed cystoscopy, is clinically significant assessing recurrence. This work provides generally detection, facilitating discovery use EV-based biomarkers.
Language: Английский
Citations
16
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 477, P. 147057 - 147057
Published: Oct. 31, 2023
Language: Английский
Citations
29
Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(6), P. 885 - 899
Published: Jan. 1, 2024
Water pollution and the global freshwater crisis are most alarming concerns of 21st century, as they threaten sustainability ecological balance environment. The growth population, climate change, expansion industrial processes main causes these issues. Therefore, effective remediation polluted water by means detoxification purification is paramount importance. To this end, nanoscience nanotechnology have emerged viable options that hold tremendous potential toward advancement wastewater treatment methods to enhance efficiency along with augmenting supply via utilization unconventional sources. Materials at nano level shown great promise applications owing their unique physicochemical properties. In focus article, we highlight role new fundamental properties scale material drastically increased due dimension (e.g. volume-surface ratio) impact treatment. We identify discuss how nano-properties could improve three domains remediation: identification pollutants, adsorption catalytic degradation. After discussing all beneficial aspects further key challenges associated nanomaterials for Looking current state-of-the-art, well nanomaterials, believe in future will see a significant materials on many strategies.
Language: Английский
Citations
12
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(41)
Published: Aug. 13, 2024
Abstract Bimetallic nanostructures are promising candidates for the development of enzyme‐mimics, yet deciphering structural impact on their catalytic properties poses significant challenges. By leveraging versatility nanocrystal aerogels, this study reports a precise control Au–Pt bimetallic structures in three representative configurations, including segregated, alloy, and core–shell structures. Benefiting from synergistic effect, these aerogels demonstrate improved peroxidase‐ glucose oxidase‐like performances compared to monometallic counterparts, unleashing tremendous potential catalyzing cascade reaction. Notably, segregated aerogel shows optimal activity, which is 2.80 3.35 times higher than that alloy variants, respectively. This enhanced activity attributed high‐density interface boundaries within structure, foster greater substrate affinity superior efficiency. work not only sheds light structure–property relationship catalysts but also broadens application scope biosensing biological detections.
Language: Английский
Citations
10
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract The development of new non‐neurotransmitter drugs is an important supplement to the clinical treatment major depressive disorder. latest mRNA therapy provides possibility for some diseases. endoplasmic reticulum (ER) and mitochondria constitute a highly interconnected set fundamental organelles within cells. interconnection between them forms specific microdomains that play pivotal roles in calcium signaling, mitochondrial dynamics, inflammation, autophagy. Perturbations ER‐mitochondrial connections may contribute progression neurological disorders other Herein, extracellular vesicles‐based delivery system, grounded gene integrated with nanomedicine technology devised. This system engineered traverse blood–brain barrier specifically target central nervous (CNS), facilitating simultaneous metallic nanozymes into brain. dual‐pronged approach, targeting ER crosstalk, inhibits microglial overactivation, promotes M2 polarization microglia, suppresses NF‐κB signaling pathway. Consequently, it significantly alleviates Lipopolysaccharides‐induced neuroinflammatory responses ameliorates anxiety‐ depression‐like behaviors. study demonstrates novel antidepressant therapeutic strategy establishes paradigm CNS
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 14, 2024
Abstract The key challenges for pursuing high‐energy‐density lithium‐sulfur (Li‐S) batteries lie in struggling sulfur conversions under high‐sulfur‐loading and low electrolyte‐to‐sulfur (E/S) ratio conditions. To mimic high‐efficient natural enzymes, this work, sulfonated cobalt phthalocyanine (CoPC) is implanted β‐cyclodextrin (β–CD) cavity preparing β–CD@CoPC biomimetic catalysts, which enables a good electrochemical contact with solvated lithium polysulfides locally enriched electrolyte. Moreover, the dynamic stereo‐conformation evolution of CoPC hydrophobic β–CD promotes subsequent redox kinetics induces separation Li 2 S from catalyst, further improving catalysis efficiency. catalytic activity quantified through specific Michaelis–Menten equations enzymatic reactions it showed that improved ability by 3 30 times compared to respectively. As result, Li–S pouch cell mere 1.0 wt% exhibits high initial areal capacity 11.6 mAh cm −2 (12.8 mg ) E/S (3.5 µL −1 ). This strategy provides feasible way tackle conversion issues lean electrolytes next‐generation high‐energy batteries.
Language: Английский
Citations
5
Journal of Analysis and Testing, Journal Year: 2024, Volume and Issue: 8(2), P. 170 - 179
Published: March 11, 2024
Language: Английский
Citations
4