Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2459 - 2470
Published: Jan. 1, 2024
Leukemia
is
a
type
of
clonal
disorder
hematopoietic
stem
and
progenitor
cells
characterized
by
bone
marrow
failure,
differentiation
arrest,
lineage
skewing.
Despite
leukemia
being
complex
disease
it
difficult
to
identify
single
driving
force,
redox
homeostasis,
the
balance
between
reactive
oxygen
species
(ROS)
producers
cellular
antioxidant
systems,
normally
impaired
during
leukemogenesis.
In
this
context,
modulation
ROS
in
can
be
harnessed
for
therapeutic
purposes.
Nanozymes
are
functional
nanomaterials
with
enzyme-like
characteristics,
which
address
intrinsic
limitations
natural
enzymes
exhibit
great
potential
synergistic
antitumor
therapy.
possess
catalytic
activities
(e.g.,
peroxidase-like
activity,
catalase-like
superoxide
dismutase-like
oxidase-like
activity)
regulate
levels
vitro
vivo,
making
them
promising
On
account
rapid
development
nanozymes
recently,
their
application
potentials
therapy
gradually
explored.
To
highlight
achievements
field,
review
summarizes
recent
studies
anti-leukemia
efficacy
underlying
mechanism.
addition,
challenges
prospects
nanozyme
research
discussed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 22, 2024
Abstract
Although
numerous
peroxidase
(POD)‐like
nanozymes
have
been
designed
for
catalytic
therapy
of
cancer,
development
with
higher
therapeutic
efficacy
and
less
adverse
effects
are
challengeable.
More
importantly,
the
underlying
antitumor
mechanism
remains
largely
unknown
which
hinders
their
application.
Here,
nitrogen‐doped
carbon
nanozyme
(N‐PCNS)
as
a
model
is
utilized
demonstrated
that
its
capacity
to
specifically
activate
STING
pathway
in
tumor
cells
through
reactive
oxgen
species
(ROS)‐mediated
mitochondrial
DNA
(mtDNA)
release,
provides
initial
signals
STING‐dependent
innate
immune
response.
Further,
peptide‐nanozyme
conjugate
(PNEC,
OPBP1‐N‐PCNS),
comprising
PD‐L1
blocking/targeting
dual‐functional
peptide
cationic‐coated
N‐PCNS
constructed,
conjugated
matrix
metalloproteinase
responsive
linker.
The
cleaved
derivate
positive
charge
exhibits
recyclable
superior
ability
capturing
enhancing
transcellular
transport
tumor‐derived
mtDNA
toward
DCs,
thereby
amplifying
signaling‐mediated
anti‐tumor
This
study
proposed
unique
design
strategy
POD‐like
cancer
immunotherapy.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(46)
Published: Aug. 2, 2024
Abstract
Tumor
microenvironment
(TME)‐responsive
nanozymes‐based
catalytic
therapy
shows
great
potential
in
combating
malignant
tumor.
However,
their
biological
application
still
suffers
from
deficient
activity.
Herein,
the
MoO
x
‐Rh
metallene
nanozyme
demonstrates
highly
efficient
multiple
enzymatic
activities,
where
species
atomically
dispersed
on
Rh
surface.
The
resulting
structures
enable
with
maximally
exposed
active
oxide‐metallene
interface
and
more
atoms
sites
around
can
be
well
finely
regulated.
Results
of
experiment
density
functional
theory
(DFT)
simulations
support
notion
that
atomic
structure
facilitates
enzyme‐like
reactions.
As
a
TME‐responsive
nanozyme,
exhibits
remarkable
therapeutic
effect
tumor
due
to
intrinsic
near‐infrared
photothermal
laser‐enhanced
activities.
This
study
illustrates
promise
engineering
strategy
therapy.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 7345 - 7354
Published: April 4, 2024
Starvation
therapy
mediated
by
glucose
oxidase
is
a
widely
used
therapeutic
approach
for
tumor
treatment,
but
it
limited
the
simultaneous
drawbacks
of
weak
efficacy,
nonspecificity,
and
systemic
toxicity.
Thus,
combination
was
to
complement
strategy
anticancer
therapy.
On
basis
starvation
therapy,
we
designed
catalytic
model
nanosheets
with
biological
cascade
enzymes
synergizing
drugs.
In
short,
two
(glucose
horseradish
peroxidase)
are
covalently
immobilized
on
Ti3C2
MXene
nanosheet
enzyme
nanoreactor
formed
electrostatically
adsorbing
positive
charged
DOX.
Finally,
outer
layer
coated
hyaluronic
acid.
By
combining
oxidase-mediated
photothermal
chemotherapy,
have
achieved
effect
"killing
three
birds
one
stone"
dual
stimulation
response
endogenous
exogenous
sources
site.
This
method
not
only
achieves
targeting
cancer
cells
also
improves
toxicity
reduced
efficacy
realizes
synergistic
enhanced
reactions.
It
opens
up
new
path
research
nanomedicine.
Small Structures,
Journal Year:
2024,
Volume and Issue:
5(7)
Published: April 26, 2024
Nanozymes,
nanomaterials
exhibiting
enzyme‐mimicking
activities,
have
gained
considerable
interest
in
biomedicine
due
to
their
stability,
adjustability,
and
cost‐efficiency.
Among
these,
metal–organic
framework
(MOF)‐based
nanozymes
distinguish
themselves
by
distinct
structure
customizable
characteristics.
Researchers
explored
MOF‐based
as
a
platform
for
developing
stimuli‐responsive
behaviors.
This
work
first
presents
the
categorization
of
nanozymes,
which
are
designed
mimic
catalytic
functions
oxidases,
peroxidases,
catalase,
superoxide
dismutase,
hydrolases,
multifunctional
enzymes.
Crafting
includes
customizing
reactions
particular
stimuli,
including
pH,
temperature,
light,
or
biomolecular
triggers,
ensuring
enhanced
specificity
potency
performance
amid
environmental
changes.
Moreover,
these
exhibit
immense
potential
biomedical
applications,
playing
crucial
roles
therapeutic
interventions
like
cancer
therapy
tissue
regeneration.
Finally,
article
delves
into
future
opportunities
challenges
within
emerging
research
frontiers.
These
offer
novel
avenues
advanced
strategies,
providing
prospects
innovative
applications.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(30)
Published: June 14, 2024
Abstract
Smart
drug
platforms
based
on
spatiotemporally
controlled
release
and
integration
of
tumor
imaging
are
expected
to
overcome
the
inefficiency
uncertainty
traditional
theranostic
modes.
In
this
study,
a
composite
consisting
thermosensitive
hydrogel
(polyvinyl
alcohol‐carboxylic
acid
(PCF))
multifunctional
nanoparticle
(Fe
3
O
4
@Au/Mn(Zn)‐4‐carboxyphenyl
porphyrin/polydopamine
(FAM
x
P))
is
developed
combine
immunogenic
cell
death
(ICD)/immune
checkpoint
blockade
(ICB)
therapy
under
guidance
magnetic
resonance
(MRI)
fluorescence
(FI).
It
can
not
only
further
recognize
target
cells
through
folate
receptor
cells,
but
also
produce
thermal
dissolution
after
exposure
near‐infrared
light
slowly
FAM
P
in
situ,
thereby
prolonging
treatment
time
avoiding
recurrence.
As
entered
it
released
pH‐dependent
manner.
Chemodynamic,
photothermal
photodynamic
cause
significant
ICD
cancer
cells.
ICB
thus
be
enhanced
by
injecting
anti‐programmed
ligand
1,
improving
effectiveness
treatment.
The
PCF‐FAM
may
represent
an
updated
design
approach
with
simple
compositions
for
cooperative
MRI/FI‐guided
targeted
therapeutic
pathways
tumors.
