Stretchable, Reversible, and Self-Healable Poly(acrylic acid) and Cement Hydrate Nanocomposite Hydrogel for Pressure and Motion Sensing DOI
Xin Liu,

Di-Ning Li,

Jinhui Tang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25784 - 25796

Published: Nov. 1, 2024

Nanocomposite hydrogels have seen significant advancements owing to the unique structural enhancements facilitated by nanoparticles. However, a persistent challenge arises because of conflicts between plasticity and shapeability that accompany nanoparticle integration. Hereby, we present an approach involves in situ formation primary cement hydrate, i.e., calcium silicate hydrogel (C–S–H), presence poly(acrylic acid) (PAA) fabricate nanocomposite PAA/CSH. Notably, resulting demonstrates remarkable attributes: stretchable, reversible, shapeable, self-healable its wet state, while exhibiting relatively high hardness nonflammability upon drying. The amorphous C–S–H nanoparticles establish strong interactions with PAA forming robust hydrogen bond network coordination, which allows serve as physical cross-linker enhancing overall properties PAA/CSH hydrogels, alongside complexation. excellent stretchability, shapeability, self-healability render suitable pressure/human motion sensors, exhibit superior response/recovery sensitivity holding considerable promise for applications artificial intelligence, soft robotics, personal healthcare, among others.

Language: Английский

Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics DOI Creative Commons
Dilip Kumar Chandra, Awanish Kumar, Chinmaya Mahapatra

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

Citations

2
Current advances in nanozyme-based nanodynamic therapies for cancer DOI
Xiangyang Zhou,

Shuaipeng Feng,

Qingqing Xu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

5
Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels DOI Creative Commons
Preeti Kush, Ranjit Singh, Parveen Kumar

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 76 - 76

Published: Jan. 18, 2025

Cancer is the second leading cause of death globally and estimated number new cancer cases deaths will be ∼30.2 million 16.3 million, respectively, by 2040. These numbers massive, physical, emotional, financial burdens to society healthcare system that lead further research for a better more effective therapeutic strategy manage cancer. Metal–organic frameworks (MOFs) are promising alternative approaches efficient drug delivery theranostics owing their unique properties direct transportation drugs into cells followed controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, formation MOF-based hydrogels abundant absorption sites, flexibility, excellent mechanical properties. This review briefly describes different strategies used synthesis characterization hydrogels. Further, we place special emphasis on recent advances in cancers. Finally, conclude challenges future perspectives We believe this help researchers develop augmented anticancer effects, enabling management even without adverse effects.

Language: Английский

Citations

0
Gold Nanoparticles-Supported Iron Oxide Particles Endows Bone Scaffolds with Anti-tumor Function DOI
Tiantian He, Wenjing Yang, Youwen Yang

et al.

Free Radical Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 12, 2025

Iron oxide (Fe-O) has anti-tumor properties, due to its ability of catalyzing hydrogen peroxide (H2O2) tumor cells generate reactive oxygen species (ROS) and then cause ferroptosis. Its performance is restricted insufficient H2O2 in cells. A nanomedicine, Au nanoparticles (NPs) grown on Fe-O, was integrated into poly-l-lactide (PLLA) scaffolds. Results indicated that NPs could consume glucose produce H2O2, which supplemented reaction substrate. PLLA/Au@Fe-O scaffold showed enhanced activities against MG63, including increased mortality, decreased migration colony formation. promoted ferroptosis up-regulation COX-2 protein, down-regulation FTH1 protein GPX4 protein. also autophagy P62 LC3BII/I. Mechanistically, possessed through promoting autophagy.

Language: Английский

Citations

0
pH-responsive carbohydrate polymer-based nanoparticles in cancer therapy DOI

Nanxi Zhao,

Yang Shi,

Pai Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141236 - 141236

Published: Feb. 1, 2025

Language: Английский

Citations

0
Organic molecule-based nanoparticles for multimodal colorectal cancer therapy: Oxidative stress-induced apoptosis and ferroptosis DOI

Dezhou Peng,

Zhibo Zhang, Qiyu Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162259 - 162259

Published: April 1, 2025

Language: Английский

Citations

0
Immunomodulatory hydrogels for tissue repair and regeneration DOI Creative Commons
Xiangjun Liu,

Yue Hu,

Yikun Ju

et al.

APL Materials, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

Tissue repair and regeneration have long been a focus of research, with growing evidence highlighting the role played by immunomodulation. The tissue cells can be significantly promoted through localized immunomodulation tissues. Hydrogels are increasingly used in this field due to their biocompatibility, versatility, relative ease fabrication. This Review highlights critical inflammation immune development complex process after injury, dynamic interactions between that ultimately influence outcome healing. We also summarize precise functions responses various injury scenarios, which for harnessing full potential immunomodulatory strategies promote repair. discuss recent advances drug-carrying hydrogels, offer promising avenues control environment constructive Further our understanding mechanisms driving cell behavior during expected foster effective hydrogel-based regeneration.

Language: Английский

Citations

2
Integration of Metal‐Organic Frameworks into Hydrogels: Optimizing Their Properties and Applications DOI
Wenjie Zhou, Mengfei Tian, Haoran Wang

et al.

Zeitschrift für anorganische und allgemeine Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Abstract In recent years, MOFs hydrogels have attracted extensive attention due to their unique structure and excellent performance. MOF‐based combine the highly ordered pore tunability of MOF with biocompatibility flexibility hydrogels, are widely used in environmental governance, sensors, biomedicine. this review, we mainly summarize synthesis methods, structural characteristics mechanical properties specific applications different fields including adsorption heavy metal ions pollutant gases stress strain sensor drug delivery. Finally, analyze existing problems, provide suggestions for development direction future. This paper aims help readers quickly understand current hydrogels.

Language: Английский

Citations

1
Stretchable, Reversible, and Self-Healable Poly(acrylic acid) and Cement Hydrate Nanocomposite Hydrogel for Pressure and Motion Sensing DOI
Xin Liu,

Di-Ning Li,

Jinhui Tang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25784 - 25796

Published: Nov. 1, 2024

Nanocomposite hydrogels have seen significant advancements owing to the unique structural enhancements facilitated by nanoparticles. However, a persistent challenge arises because of conflicts between plasticity and shapeability that accompany nanoparticle integration. Hereby, we present an approach involves in situ formation primary cement hydrate, i.e., calcium silicate hydrogel (C–S–H), presence poly(acrylic acid) (PAA) fabricate nanocomposite PAA/CSH. Notably, resulting demonstrates remarkable attributes: stretchable, reversible, shapeable, self-healable its wet state, while exhibiting relatively high hardness nonflammability upon drying. The amorphous C–S–H nanoparticles establish strong interactions with PAA forming robust hydrogen bond network coordination, which allows serve as physical cross-linker enhancing overall properties PAA/CSH hydrogels, alongside complexation. excellent stretchability, shapeability, self-healability render suitable pressure/human motion sensors, exhibit superior response/recovery sensitivity holding considerable promise for applications artificial intelligence, soft robotics, personal healthcare, among others.

Language: Английский

Citations

0