Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)
Published: March 7, 2025
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122
Published: Aug. 6, 2024
Language: Английский
Citations
17
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application tumors. To overcome these limitations, a self‐sustained organelle‐mimicking nanoreactor is developed here with programmable DNA switches that enables bio‐chem‐photocatalytic cascade‐driven starvation‐photodynamic synergistic against tumor metastasis. Emulating compartmentalization positional assembly strategies found living cells, this nano‐organelle reactor allows quantitative co‐compartmentalization multiple functional modules designed self‐illuminating chemiexcited PDT system. Within space‐confined nanoreactor, biofuel glucose converted hydrogen peroxide (H 2 O ) which enhances luminol‐based chemiluminescence (CL), consequently driving generation photochemical singlet ( 1 via resonance energy transfer. Meanwhile, hemoglobin functions as synchronized supplier both oxidation PDT, while also exhibiting peroxidase‐like activity produce hydroxyl radicals (·OH). Crucially, keeps switching off normal tissues, on‐demand activation tumors through toehold‐mediated strand displacement. These findings demonstrate self‐sufficient precise striking tumors, promising paradigm managing highly metastatic cancers.
Language: Английский
Citations
2
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 31, 2025
Language: Английский
Citations
2
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: Nov. 11, 2024
Cancer has emerged as a formidable challenge in the 21st century, impacting society, public health, and economy. Conventional cancer treatments often exhibit limited efficacy considerable side effects, particularly managing advanced stages of disease. Photodynamic therapy (PDT), contemporary non-invasive therapeutic approach, employs photosensitizers (PS) conjunction with precise light wavelengths to selectively target diseased tissues, inducing generation reactive oxygen species ultimately leading cell apoptosis. In contrast conventional therapies, PDT presents lower incidence effects greater precision targeting. The integration intelligent nanotechnology into markedly improved its effectiveness, evidenced by remarkable synergistic antitumor observed utilization multifunctional nanoplatforms PDT. This paper provides concise overview principles underlying PS PDT, while also delving nanomaterial-based context treatment.
Language: Английский
Citations
10
Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5815 - 5842
Published: Jan. 1, 2024
The current state-of-the art on NIR-II-activated photosensitizers and their applications for the deep tumor treatment, as well recent efforts that combine NIR-II activated PDT with other complementary therapeutic routes.
Language: Английский
Citations
8
Theranostics, Journal Year: 2024, Volume and Issue: 14(14), P. 5461 - 5491
Published: Jan. 1, 2024
Gas therapy, a burgeoning clinical treatment modality, has garnered widespread attention to treat variety of pathologies in recent years. The advent nanoscale gas drug therapy represents novel therapeutic strategy, particularly demonstrating immense potential the realm oncology. This comprehensive review navigates landscape gases endowed with anti-cancer properties, including hydrogen (H
Language: Английский
Citations
8
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced precision and safety. To enhance deep tissue penetration minimize adsorption phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significant potential. However, the efficacy of PDT is often impeded tumor microenvironment hypoxia, primarily caused irregular vasculature. Fortunately, stimulator interferon genes (STING) pathway, known immune activation, has been linked vasculature normalization. In this study, we developed nanoplatform (Fe-THBQ/SR) loading STING agonist (SR-717) into an iron-tetrahydroxy-1,4-benzoquinone (Fe-THBQ) metal–organic framework. Fe-THBQ was proven be effective NIR-II photosensitizer, generating numerous reactive oxygen species (ROS) under 1064 nm laser irradiation. These ROS downregulated heat shock protein expression, consequently promoting mild-photothermal (mild-PTT), facilitated ferroptosis depleting glutathione (GSH)/glutathione peroxidase 4. Moreover, Fe-THBQ/SR released SR-717 upon GSH stimulation, synergizing with ROS-mediated double-stranded DNA leakage activation. This process contributed normalization hypoxia alleviation, thereby enhancing efficacy. Overall, presented versatile single-laser-triggered mild-PTT simultaneously coupled it activation form reinforcing cycle. synergistic enhancements increased immunogenicity cells, remodeled immunosuppressive microenvironment, T lymphocyte infiltration, improved therapeutic outcomes.
Language: Английский
Citations
1
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: March 13, 2024
Photodynamic therapy (PDT), a promising treatment modality, employs photosensitizers to generate cytotoxic reactive oxygen species (ROS) within localized tumor regions. This technique involves administering photosensitizer followed by light activation in the presence of (O 2 ), resulting ROS production. PDT’s spatiotemporal selectivity, minimally invasive nature, and compatibility with other modalities make it compelling therapeutic approach. However, hypoxic microenvironment (TME) poses significant challenge conventional PDT. To overcome this hurdle, various strategies have been devised, including in-situ O generation, targeted delivery, vasculature normalization, modulation mitochondrial respiration, photocatalytic generation. review aims provide comprehensive overview recent developments designing tumor-oxygenated nanomaterials enhance PDT efficacy. Furthermore, we delineate ongoing challenges propose improve clinical impact cancer treatment.
Language: Английский
Citations
7
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)
Published: April 8, 2024
Dyes with extended conjugate structures are the focus of extensive design and synthesis efforts, aiming to confer unique improved optical electronic properties. Such advancements render these dyes applicable across a wide spectrum uses, ranging from second-window near-infrared (NIR-II) bioimaging organic photovoltaics. Nevertheless, inherent benefits long conjugation often accompanied by persistent challenges like aggregation, fluorescence quenching, absorption blueshift, low stability poor water solubility. Herein, structural strategy termed "homo-dyad outer hydration layer" is introduced address problems, tailored for development imaging probes exhibiting absorption/emission wavelengths. This approach involves bringing two heptamethine cyanines together through flexible linker, forming homo-dyad structure, while strategically attaching four polyethylene glycol (PEG9) chains terminal heterocycles. imparts excellent solubility, biocompatibility, enhanced chemical, photo-, spectral dyes. Utilizing this strategy, biomarker-activatable probe (HD-FL-4PEG9-N) NIR-II fluorescent 3D multispectral optoacoustic tomography developed, its effectiveness in disease visualization. It can not only serve as an injectable acute kidney injury due high but also sprayable bacterial-infected wounds.
Language: Английский
Citations
6
Nano Letters, Journal Year: 2024, Volume and Issue: 24(43), P. 13708 - 13717
Published: Oct. 17, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems possess immense potential for targeted and controlled release of therapeutics. However, the rapid responsiveness to ROS sustained antibacterial drugs are often limited by challenging microenvironment periodontitis. Integrating ROS-responsive with photocatalytic technologies presents a strategic approach overcome these limitations. Herein, pillararene-embedded covalent organic framework (PCOF) incorporating prodrug thioacetal (TA) has been developed treat This drug-loaded nanoplatform, namely TA-loaded PCOF, utilizes self-amplifying property enhance therapeutic efficacy. PCOFs demonstrate exceptional photosensitivity generation capabilities when employed as carriers. When exposed ROS, TA within nanoplatform was activated cleaved into cinnamaldehyde (CA), highly potent compound. By leveraging visible light activate site-specific infection targeting, PCOF effectively alleviated periodontitis, thereby advancing field systems.
Language: Английский
Citations
6