Intelligent Supramolecular Modification for Implants: Endogenous Regulation of Bone Defect Repair in Osteoporosis DOI

Xingyu Zhou,

Junhui Jiang,

Junbo Dang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Abstract Addressing osteoporosis‐related bone defects, a supramolecular strategy is innovated for modifying carbon fiber reinforced polyether ether ketone (CF/PEEK) composites. By covalently attaching intelligent macromolecules via in situ RAFT polymerization, leveraging the unique pathological microenvironment patients with iron‐overloaded osteoporosis, modified implant surface possesses multiple endogenous modulation capabilities. After implantation, brush‐like initially resist macrophage adhesion, thereby reducing level of immune inflammation. Over time, molecular chains undergo conformational changes due to Fe (III) mediated self‐assembly, transforming into mechanistic signals. These signals are then specifically transmitted pre‐osteoblast cell through binding capacity KRSR short peptide at terminus, induced their osteogenic differentiation YAP/β‐catenin signaling axis. Furthermore, osteoblasts secrete alkaline phosphatase (ALP), which significantly hydrolyzes phosphate ester bonds macromolecular side groups, resulting release alendronate (ALN). This process further improves local osteoporotic microenvironment. modification tailors repair individual conditions, automatically realize regulation once implanted, and truly spontaneous activation series responses conducive vivo. It evidenced by improved regeneration rabbits supported vitro validations.

Language: Английский

Loading curcumin on hyperbranched polymers functionalized Zein via the phenol-yne click reaction as pH-responsive drug delivery system for chemotherapy and photodynamic therapy DOI
Mei‐Ying Liu, Tongsheng Huang, Yiping Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139750 - 139750

Published: Jan. 1, 2025

Language: Английский

Citations

2
ROS-scavenging bioactive scaffold orchestrates bone regeneration for osteoporotic bone defect repair DOI
Liang Xiao,

Xindi Yang,

Jing Liu

et al.

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 281, P. 111528 - 111528

Published: May 4, 2024

Language: Английский

Citations

15
Estrogen and estrogen receptors mediate the mechanobiology of bone disease and repair DOI
Vivian Y. Shi, Elise F. Morgan

Bone, Journal Year: 2024, Volume and Issue: 188, P. 117220 - 117220

Published: Aug. 5, 2024

Language: Английский

Citations

11
Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway DOI Creative Commons
Yue Li, Yingying Fan, Siyu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 5, 2024

Language: Английский

Citations

9
Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases DOI Creative Commons
Wei Wang, Junjie Wang, Ziwei Hu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.

Language: Английский

Citations

9
Structure-optimized and microenvironment-inspired nanocomposite biomaterials in bone tissue engineering DOI Creative Commons

Zheng Lv,

Ying Ji,

Guoliang Wen

et al.

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Abstract Critical-sized bone defects represent a significant clinical challenge due to their inability undergo spontaneous regeneration, necessitating graft interventions for effective treatment. The development of tissue-engineered scaffolds and regenerative medicine has made tissue engineering highly viable treatment defects. physical biological properties nanocomposite biomaterials, which have optimized structures the ability simulate microenvironment bone, are promising application in field engineering. These biomaterials offer distinct advantages over traditional materials by facilitating cellular adhesion proliferation, maintaining excellent osteoconductivity biocompatibility, enabling precise control degradation rates, enhancing mechanical properties. Importantly, they can natural structure tissue, including specific microenvironment, is crucial promoting repair regeneration This manuscript provides comprehensive review recent research developments applications structure-optimized microenvironment-inspired focuses on these summarizing latest progress highlighting challenges future perspectives field. Through this analysis, paper aims underscore potential engineering, contributing informed design strategic planning next-generation medicine.

Language: Английский

Citations

8
Extracellular Vesicle‐Inspired Therapeutic Strategies for the COVID‐19 DOI
Ziwei Hu, Wei Wang,

Ying Lin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: June 25, 2024

Emerging infectious diseases like coronavirus pneumonia (COVID-19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID-19 diagnosis treatment. However, due limitations in performance titer of natural vesicles, their clinical use remains limited. Nonetheless, EV-inspired strategies are gaining increasing attention. Notably, biomimetic inspired by EVs, possess specific receptors that can act "Trojan horses," preventing virus from infecting host cells. Genetic engineering enhance these enabling them carry more receptors, significantly specificity absorbing novel coronavirus. Additionally, inherit numerous cytokine parent cells, allowing effectively mitigate "cytokine storm" adsorbing pro-inflammatory cytokines. Overall, this strategy offers new avenues treatment emerging diseases. Herein, review systematically summarizes current applications COVID-19. The status associated with implementation also discussed. goal is provide insights into design expand application combating

Language: Английский

Citations

7
Bone‐Targeting and Multishelled Oral Eldecalcitol Nanoparticles Improve Osteoporosis by Reconstruction of Osteogenic‐Osteoclastic Homeostasis DOI
Lingxiao Meng, Wanli Ma, Yuping Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 23, 2024

Abstract Current treatment of postmenopausal osteoporosis (PMOP) focuses on systemic administration medication, neglecting to proactively modulate the local microenvironment skeletal system for superior therapeutic performance. Eldecalcitol (ED‐71), a novel drug treating osteoporosis, still requires research overcome high‐frequency delivery and low‐utilization. Here, bone‐targeting multishelled nanoparticles are developed step‐wise release ED‐71. The achieved by using chitosan/alginate outer layer as protective barrier against gastric acid, pectin middle adhesive agent that improved intestinal penetration, ethylene diamine tetraacetic acid‐grafted mesoporous silica nanomaterials core nanocarriers. After oral administration, ED‐71‐loaded (ME‐ED‐71@PCA) promotes osteogenic differentiation bone marrow mesenchymal stem cells reducing intracellular oxidative stress, inhibits osteoclast differentiation. ME‐ED‐71@PCA improves mass in ovariectomized‐mice promoting osteogenesis inhibiting osteoclastogenesis, efficacy is more pronounced than ED‐71 alone. exhibits satisfactory performance due its compared providing new approach re‐establish metabolic homeostasis PMOP.

Language: Английский

Citations

6
Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice DOI
Peng Luo,

Yanlong Zhong,

Xiaowei Yang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114495 - 114495

Published: Jan. 5, 2025

Language: Английский

Citations

0
Regulation of Bone Remodeling by Metal–Phenolic Networks for the Treatment of Systemic Osteoporosis DOI Creative Commons
Xi Chen, Weihui Wu, Wei Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Osteoporosis is a systemic metabolic disease that impairs bone remodeling by favoring osteoclastic resorption over osteoblastic formation. Nanotechnology-based therapeutic strategies focus on the delivery of drug molecules to either decrease or increase formation rather than regulating entire process, and osteoporosis interventions suffer from this limitation. Here, we present multifunctional nanoparticle based metal-phenolic networks (MPNs) for treatment both osteoclasts osteoblasts. In osteoporotic microenvironment, MPN nanoparticles degrade trigger release bioactive metals (strontium ions, SrII) promote osteogenesis functionalized phenols (epigallocatechin gallate, EGCG) suppress osteoclastogenesis. Injecting these into tail vein an ovariectomized mouse model, trabecular loss has been significantly prevented in femoral head vertebrae, along with increased volume decreased separation. Overall, work represents versatile approach explore nanomaterials related orthopedic diseases.

Language: Английский

Citations

0