Antibiotic
resistance
in
bacterial
pathogens
is
a
global
health
problem
requiring
enormous
research
into
alternative,
easily
accessible
antibacterial
substances
and
treatments
to
replace
antibiotics.
Components
of
essential
oils
(EOs)
that
possess
broad-spectrum
properties
are
promising
candidates.
However,
due
their
high
volatility
low
solubility,
administration
remains
difficult.
A
method
load
materials
with
the
active
component
design
triggered
release
system
avoid
rapid
exhaustion
carried
material.
If
such
drug-release
would
additionally
exhibit
itself,
it
could
significantly
advance
combatting
infections.
Therefore,
present
study,
we
combine
light-triggered
simultaneous
antimicrobial
substance
thymol
photodynamic
therapy
(aPDT)
within
one
nanoparticle.
The
irradiation
an
immobilized
photosensitizer
produces
reactive
oxygen
species
(ROS)
oxidatively
cleave
linker
ultimately
releases
detected
by
GC-MS.
Antibacterial
towards
Staphylococcus
aureus
biofilm
formation
were
verified
ATP-based
viability
assay.
To
improve
application
for
deep
tissue
delivery,
also
take
account
transmittance
visible
light.
highly
developed
trifunctional
material
enables
2-photon
excitation
via
Förster
resonance
energy
transfer
(FRET)
thus
shifts
wavelength
biological
window.
third
functionality
can
be
monitored
situ
fluorescence
microscopy.
This
model
lays
foundation
future
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(43), P. 13708 - 13717
Published: Oct. 17, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
possess
immense
potential
for
targeted
and
controlled
release
of
therapeutics.
However,
the
rapid
responsiveness
to
ROS
sustained
antibacterial
drugs
are
often
limited
by
challenging
microenvironment
periodontitis.
Integrating
ROS-responsive
with
photocatalytic
technologies
presents
a
strategic
approach
overcome
these
limitations.
Herein,
pillararene-embedded
covalent
organic
framework
(PCOF)
incorporating
prodrug
thioacetal
(TA)
has
been
developed
treat
This
drug-loaded
nanoplatform,
namely
TA-loaded
PCOF,
utilizes
self-amplifying
property
enhance
therapeutic
efficacy.
PCOFs
demonstrate
exceptional
photosensitivity
generation
capabilities
when
employed
as
carriers.
When
exposed
ROS,
TA
within
nanoplatform
was
activated
cleaved
into
cinnamaldehyde
(CA),
highly
potent
compound.
By
leveraging
visible
light
activate
site-specific
infection
targeting,
PCOF
effectively
alleviated
periodontitis,
thereby
advancing
field
systems.
