Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

Advances in Radionuclide-Labeled Biological Carriers for Tumor Imaging and Treatment DOI
Yaozhang Yang, Jing Wang,

Yan Zhong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Biological carriers have emerged as significant tools to deliver radionuclides in nuclear medicine, providing a meaningful perspective for tumor imaging and treatment. Various radionuclide-labeled biological been developed meet the needs of biomedical applications. This review introduces principles radionuclide-mediated therapy selected criteria them, well comprehensive description characteristics functions representative including bacteria, cells, viruses, their derivatives, emphasizing labeled strategies combined with radionuclides. Subsequently, we in-depth introduce application treatment, behaviors vivo metastasis treatment by radionuclide therapy, plus other radiation-induced photodynamic therapy. Finally, challenges prospects are discussed improve shortcomings this innovative platform promote clinical transformation field medical imaging.

Language: Английский

Citations

1
Tumor-stromal opening via S. typhimurium VNP20009 administration for complete inhibition of refractory tumor growth with liposomal anticancer drugs DOI Creative Commons

Akari Kato,

Shoko Nomura,

Maiko Takahashi

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Stealth Missiles with Precision Guidance: A Novel Multifunctional Nano-Drug Delivery System Based on Biomimetic Cell Membrane Coating Technology DOI Creative Commons

Yuyan Zhou,

Xinyue Wang, Xiaorong Tian

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101922 - 101922

Published: May 1, 2025

Language: Английский

Citations

0
The Role of Bacteria in Central Nervous System Tumors: Opportunities and Challenges DOI Creative Commons
Rui Zhang, Xueying Li, Si Zhang

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1053 - 1053

Published: May 23, 2024

Tumors of the central nervous system (CNS) are severe and refractory diseases with poor prognosis, especially for patients malignant glioblastoma brain metastases. Currently, numerous studies have explored potential role bacteria intestinal flora in tumor development treatment. Bacteria can penetrate blood-brain barrier (BBB), targeting hypoxic microenvironment at core tumors, thereby eliminating tumors activating both innate adaptive immune responses, rendering them promising therapeutic agents CNS tumors. In addition, engineered derivatives, such as bacterial membrane proteins spores, also be used good candidate carriers targeted drug delivery. Moreover, regulate metabolism influence through "gut-brain axis". Therefore, anti-tumor therapy, delivery, intervention provide modalities treatment this paper, we performed a comprehensive review mechanisms practices therapy discussed future research directions field.

Language: Английский

Citations

2
Harnessing and Mimicking Bacterial Features to Combat Cancer: From Living Entities to Artificial Mimicking Systems DOI
Peng Gao, Zhenyu Duan, Gang Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: Aug. 1, 2024

Bacterial-derived micro-/nanomedicine has garnered considerable attention in anticancer therapy, owing to the unique natural features of bacteria, including specific targeting ability, immunogenic benefits, physicochemical modifiability, and biotechnological editability. Besides, bacterial components have also been explored as promising drug delivery vehicles. Harnessing these features, cutting-edge biotechnologies applied attenuated tumor-targeting bacteria with properties or functions for potent effective cancer treatment, strategies gene-editing genetic circuits. Further, advent bacteria-inspired micro-/nanorobots mimicking artificial systems furnished fresh perspectives formulating developing highly efficient systems. Focusing on advantages this review delves into advances bacteria-derived treatment recent years, which experienced a process from living entities Meanwhile, summary relative clinical trials is provided primary challenges impeding their application are discussed. Furthermore, future directions suggested combat cancer.

Language: Английский

Citations

2
Bacteria-Based Bioactive Materials for Tumor Immunotherapy DOI Creative Commons

Yongcan Li,

Fangfang Cao, Lie Ma

et al.

Precision medicine and engineering., Journal Year: 2024, Volume and Issue: unknown, P. 100013 - 100013

Published: Nov. 1, 2024

Language: Английский

Citations

2
Recent Advances in Bacterial Outer Membrane Vesicles: Effects on the Immune System, Mechanisms and their Usage for Tumor Treatment DOI Creative Commons
Shuo Xiang, Arshad Khan, Qiufang Yao

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(12), P. 101049 - 101049

Published: July 23, 2024

Tumor treatment remains a significant medical challenge, with many traditional therapies causing notable side effects. Recent research has led to the development of immunotherapy, which offers numerous advantages. Bacteria inherently possess motility, allowing them preferentially colonize tumors and modulate tumor immune microenvironment, thus influencing efficacy immunotherapy. Bacterial outer membrane vesicles (OMVs) secreted by gram-negative bacteria are nanoscale lipid bilayer structures rich in bacterial antigens, pathogen-associated molecular patterns (PAMPs), various proteins, vesicle structures. These features allow OMVs stimulate system activation, generate responses, serve as efficient drug delivery vehicles. This dual capability enhances effectiveness immunotherapy combined chemotherapy or phototherapy, thereby improving anticancer efficacy. Current concentrated on engineering enhance production yield, minimize cytotoxicity, improve safety treatments. Consequently, hold great promise for applications vaccine development, delivery. article provides an overview structural composition mechanisms OMVs, details modification strategies, reviews progress using their anti-tumor mechanisms. Additionally, it discusses challenges faced translating OMV-based into clinical practice, aiming provide comprehensive understanding OMVs' potential in-depth application.

Language: Английский

Citations

1
Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

Citations

1