Enhanced cGAS‐STING Activation and Immune Response by LPDAM Platform‐Based Lapachone–Chemical–Photothermal Synergistic Therapy for Colorectal Cancer

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract The cGAS‐STING signaling pathway is a pivotal immune response mechanism that bridges tumor and cell interactions. This study describes multifunctional LPDAM nanoplatform integrating Lapachone, polydopamine (PDA), Mn 2+ , which synergistically kills cells activates the pathway, thereby inducing DC maturation T activation to achieve potent antitumor immunity. In microenvironment, Lapachone generates H 2 O via NAD(P)H:quinone oxidoreductase 1 (NQO1 enzyme), while catalyze conversion into •OH through chemodynamic effects (CDT). photothermal (PTT) of PDA further amplify this cascade reaction, producing reactive oxygen species (ROS) damage mitochondria release mitochondrial DNA (mtDNA). released mtDNA enhances sensitivity cGAS mtDNA, leading robust Concurrently, photothermal‐induced immunogenic death (ICD) promotes d endritic ( DCs) maturation, strengthening responses. Moreover, ⁺ also serves as contrast agent for T1‐weighted magnetic resonance imaging (MRI), offering precise visualization. demonstrates facilitates Lapachone/CDT/PTT synergistic therapy under MRI guidance, showcasing its potential an innovative strategy combined immunotherapy in clinical oncology.

Language: Английский

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Construction of In Situ Personalized Cancer Vaccines by Bioorthogonal Catalytic Microneedles for Augmented Melanoma Immunotherapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

In situ personalized tumor vaccines are produced directly at the primary site by killing cancer cells and stimulating immune cells, they effective against individuals bypass complexity high cost of in vitro vaccine production. However, their clinical application is hindered insufficient efficiency inducing immunogenic cell death (ICD) systemic inflammation caused adjuvants. Here, constructed for melanoma immunotherapy based on bioorthogonal catalytic microneedles, which enable release prodrugs sites mediate strong ICD an enhanced response while avoiding storms toxic side effects. By incorporating TiO2 nanosheets supported Pd into swellable microneedles to catalyze depropargylation reaction doxorubicin (DOX) prodrug imiquimod (IMQ) situ. The activated DOX subcutaneous induced released tumor-associated antigens. Concurrently, IMQ acts as a Toll-like receptor (TLR7) agonist, enhancing anti-tumor response. vivo experiments demonstrate that this achieves ≈97% inhibition tumors effectively inhibits untreated distant (≈94% inhibition) lung metastasis (≈92% inhibition).

Language: Английский

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Revolutionizing drug delivery: The power of stimulus-responsive nanoscale systems

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154265 - 154265

Published: July 24, 2024

Language: Английский

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Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract With the integration of bioelectronics and materials science, implantable self‐powered systems for electrical stimulation medical devices have emerged as an innovative therapeutic approach, garnering significant attention in research. These achieve self‐powering through integrated energy conversion modules, such triboelectric nanogenerators (TENGs) piezoelectric (PENGs), significantly enhancing portability long‐term efficacy equipment. This review delves into design strategies clinical applications systems, encompassing optimization harvesting selection fabrication adaptable electrode materials, innovations systematic strategies, extensive utilization biological therapies, including treatment neurological disorders, tissue regeneration engineering, drug delivery, tumor therapy. Through a comprehensive analysis latest research progress, technical challenges, future directions these areas, this paper aims to provide valuable insights inspiration further systems.

Language: Английский

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Nanoscale covalent organic framework-mediated pyroelectrocatalytic activation of immunogenic cell death for potent immunotherapy

Science Advances, Journal Year: 2024, Volume and Issue: 10(48)

Published: Nov. 29, 2024

The conventional molecular immunogenic cell death (ICD) inducers suffer from poor biocompatibility and unsatisfactory efficacy. Here, a biocompatible nanosized covalent organic framework (nCOF)–based pyroelectric catalyst (denoted as TPAD-COF NPs) is designed for catalysis-activated in situ immunotherapy. NPs confine molecules to rigid substantially reduce aggregation enhance biocompatibility, thus improving pyroelectrocatalytic efficiency. After tumor internalization, facilitate photothermal ablation under near-infrared (NIR) laser exposure, resulting effective ICD induction. In addition, effectively catalyze the conversion of temperature changes changes, which subsequently react with adjacent O 2 generate reactive oxygen species, triggering robust activation. vivo evaluation using mouse models confirmed that evidently inhibited proliferation primary distant tumors prevented lung metastasis NIR illumination. Therefore, this study opens an avenue designing nCOF-based catalysts

Language: Английский

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A tumor Microenvironment-triggered protein-binding Near-infrared-II Theranostic nanoplatform for Mild-Temperature photothermal therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 375 - 388

Published: Nov. 9, 2024

Language: Английский

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