International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3031 - 3031
Published: March 26, 2025
The
therapeutic
potential
of
extracellular
vesicles
(EVs)
in
reducing
oral
inflammation
is
thoroughly
examined
this
review,
with
an
emphasis
on
gingivitis,
periodontitis,
and
mucositis.
It
explains
the
complex
relationship
between
microbial
dysbiosis
host
immune
responses
aetiology
inflammation.
Pathophysiological
mechanisms
periodontitis
are
examined,
emphasising
roles
played
by
periodontal
pathogens
inflammatory
mediators
disease's
chronic
course
systemic
effects.
Preclinical
research
providing
new
evidence
that
EVs
originating
from
various
cellular
sources
control
cell
dynamics
towards
a
pro-healing
phenotype,
promote
tissue
regeneration,
have
immunomodulatory
qualities.
EV-based
therapies
appear
to
be
promising
technique
benefits
over
traditional
methods
for
treatment
illnesses
specifically
altering
signalling
pathways.
This
review
highlights
improve
patient
outcomes
health
emphasises
need
additional
clinical
clarify
efficacy
underlying
therapy.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101443 - 101443
Published: Jan. 5, 2025
Glioblastoma
(GBM)
is
the
most
prevalent
primary
malignant
brain
tumor,
characterized
by
a
high
mortality
rate
and
poor
prognosis.
The
blood-brain
barrier
(BBB)
blood-tumor
(BTB)
present
significant
obstacles
to
efficacy
of
tumor-targeted
pharmacotherapy,
thereby
impeding
therapeutic
potential
numerous
candidate
drugs.
Targeting
delivery
adequate
doses
drug
across
BBB
treat
GBM
has
become
prominent
research
area
in
recent
years.
This
emphasis
driven
exploration
evaluation
diverse
technologies
for
with
some
already
undergoing
clinical
trials.
review
provides
thorough
overview
advancements
challenges
targeted
treatment.
It
specifically
emphasizes
systemic
administration
strategies
assess
their
limitations
Furthermore,
this
highlights
promising
future
directions
development
intelligent
systems
aimed
at
overcoming
current
enhancing
against
GBM.
These
not
only
support
foundational
on
but
also
offer
methodological
approaches
applications.
Neuroglia,
Journal Year:
2025,
Volume and Issue:
6(1), P. 3 - 3
Published: Jan. 4, 2025
Background/Objectives:
Glioblastoma
(GBM),
a
highly
aggressive
grade
IV
astrocytoma,
poses
major
therapeutic
challenge
due
to
the
resistance
of
cancer
stem
cells
(CSCs)
existing
within
its
cell
population
conventional
therapies.
Recently,
we
reported
that
RNA
interference
targeting
CSC
protection
mechanism
significantly
improved
efficacy.
However,
challenges
remain,
including
limited
transfection
efficiency
in
neural
and
difficulty
crossing
blood–brain
barrier
(BBB).
Methods:
In
this
study,
investigated
potential
exosome-mediated
delivery
cargo
GBM
by
engineering
exosomes
carry
green
fluorescent
protein
(GFP)
expressing
brain-homing
peptide
(BHP)
on
their
surface,
which
has
high
affinity
cells.
Results:
We
found
BHP-modified
doubled
GFP
efficacy
from
20%
40%,
outperforming
traditional
methods
like
lipofection
vitro.
vivo,
demonstrated
an
ability
cross
BBB
targeted
brain
regions
following
intranasal
subcutaneous
administration.
Conclusions:
These
results
underscore
engineered
for
efficient
enhance
against
tumors
suggest
novel
avenues
delivering
biomolecules
treatment
neurological
disorders.
International Journal of Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
55(3)
Published: Jan. 8, 2025
Exosomes
are
integral
to
the
pathophysiology
of
osteoarthritis
(OA)
due
their
roles
in
mediating
intercellular
communication
and
regulating
inflammatory
processes.
transport
bioactive
molecules,
such
as
proteins,
lipids
nucleic
acids,
which
can
influence
chondrocyte
behavior
joint
homeostasis.
Given
properties
regeneration
ability
target
damaged
tissues,
exosomes
represent
a
promising
therapeutic
avenue
for
OA
treatment.
have
potential
promoting
cartilage
repair,
reducing
inflammation
improving
overall
function.
However,
several
challenges
remain,
including
need
standardized
isolation
characterization
methods,
variability
exosomal
content,
regulatory
hurdles.
The
present
review
aims
provide
comprehensive
overview
current
understanding
exosome
mechanisms
potential,
while
also
addressing
ongoing
faced
translating
these
findings
into
clinical
practice.
By
consolidating
existing
research,
pave
way
future
studies
aimed
at
optimizing
exosome‑based
therapies
effective
management.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12911 - 12911
Published: Nov. 30, 2024
Cartilage
degeneration
is
a
key
feature
of
aging
and
osteoarthritis,
characterized
by
the
progressive
deterioration
joint
function,
pain,
limited
mobility.
Current
treatments
focus
on
symptom
relief,
not
cartilage
regeneration.
Mesenchymal
stromal
cells
(MSCs)
offer
promising
therapeutic
option
due
to
their
capability
differentiate
into
chondrocytes,
modulate
inflammation,
promote
tissue
This
review
explores
potential
MSCs
for
regeneration,
examining
biological
properties,
action
mechanisms,
applications
in
preclinical
clinical
settings.
derived
from
bone
marrow,
adipose
tissue,
other
sources
can
self-renew
multiple
cell
types.
In
cartilage,
they
aid
regeneration
secreting
growth
factors
cytokines
that
enhance
repair
immune
responses.
Recent
studies
show
restore
integrity,
reduce
improve
although
translation
remains
challenging
limitations
such
as
viability,
scalability,
regulatory
concerns.
Advancements
MSC
delivery,
including
scaffold-based
approaches
engineered
exosomes,
may
effectiveness.
Potential
risks,
tumorigenicity
rejection,
are
also
discussed,
emphasizing
need
optimized
treatment
protocols
large-scale
trials
develop
effective,
minimally
invasive
therapies
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 1, 2025
Extracellular
particles
(EPs),
including
extracellular
vesicles
(EVs)
and
non-vesicular
(NVEPs),
are
multimolecular
biomaterials
released
by
cells
that
play
a
crucial
role
in
intercellular
communication.
Recently,
new
subtypes
of
EPs
associated
with
central
nervous
system
(CNS),
such
as
exophers
supermeres
have
been
identified.
These
provide
perspectives
for
understanding
the
pathological
progression
CNS
disorders
confer
potential
diagnostic
value
liquid
biopsies
neurodegenerative
diseases
(NDs).
Moreover,
emerged
promising
drug
delivery
vehicles
targeted
platforms
CNS-specific
therapies.
In
this
review,
we
delineate
landscape
EP
their
roles
pathophysiology
diseases.
We
also
review
recent
advances
EP-based
diagnosis
NDs
highlight
importance
analytical
single-particle
resolution
exploitation
biomarkers.
Furthermore,
summarize
application
engineered
EVs
treatment
outline
underexplored
NVEPs
novel
therapeutic
agents.
