Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.

Language: Английский

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Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Language: Английский

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The potential application of electrical stimulation in tendon repair: a review

Med-X, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 4, 2025

Language: Английский

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Mechanoredox‐Catalyzed Organic Synthesis with Piezoelectric Materials: Quo Vadis?

ChemCatChem, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Piezoelectric materials offer great promise due to their ability generate electric fields under mechanical stress, producing surface charges that drive otherwise kinetically sluggish redox reactions. The strained surfaces of these provide a unique advantage in controlling product selectivity and enabling reaction pathways are unattainable with conventional methods. This perspective highlights advancements, challenges, the future potential piezoelectric synthetic organic chemistry, focus on designing optimized for piezocatalyzed synthesis. Piezocatalysis is industrially relevant because its operational simplicity, mild, gram scale synthesis reusable catalysts, minimal solvent use, air tolerant conditions. It involves cycles facilitate one electron events without requiring light exposure or electrical bias. Despite significant progress, many fundamental aspects yet be fully understood. One example correlation between piezoelectricity catalytic activity, which not always linear, as demonstrated by comparison tetragonal cubic BaTiO₃. While BaTiO₃ piezoelectric, it shows excellent activity certain reactions such arylation, dicarbonylation, cyclization mechanochemical conditions comparable Considering all aspects, this aims stimulate discussion advance promising field right direction.

Language: Английский

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Construction of a Microenvironment‐Responsive Antibacterial Hydrogel Packed With Immunomodulatory Carbonized Polymer Dots for Periodontitis Treatment From Multiple Perspectives

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Periodontitis is an increasingly prevalent oral inflammatory disease, whose treatment faces potent challenges because of recurrent bacterial infections, excessive reactive oxygen species (ROS) production, as well unrelenting inflammation‐induced alveolar bone resorption during the pathological process. Herein, we present rational design and construction a multifunctional hydrogel platform composed quaternized chitosan/oxidized dextran (QCS/OD) component with high bactericidal activity immunomodulatory carbonized polymer dots from resveratrol (RSV‐CPDs) for periodontitis treatment. Such RSV‐CPDs@QCS/OD (RCQD) hydrogels exhibit characteristics including shape adaptability, self‐healing properties, pH‐responsibility, enabling it to adapt irregularly shaped periodontal tissues, degrade gradually in mildly acidic microenvironment periodontitis, release RSV‐CPDs controlled manner. Significantly, RCQD can effectively suppress proliferation bacteria alleviate oxidative stress, relieve inflammation via activating Nrf2/NF‐κB signaling pathway, ultimately fostering favorable environment regeneration both soft hard tissue. Overall, this study highlights great potential treating by addressing practical needs tissue regeneration.

Language: Английский

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Butterfly‐Inspired Hierarchical Hybrid Composites for Lightweight Structural Thermal Management Applications

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Stringent environmental policies and sustainability targets are driving the adoption of lightweight materials in high‐performance transportation defense sectors. Inspired by nature's unparalleled engineering, this work introduces butterfly‐inspired hybrid composites that emulate multifunctional performance natural architectures. Specifically, these reinforced with hierarchical fibrous assemblies comprised nano‐sized graphene nanoplatelets covalently bonded onto micro‐sized glass fibers, emulating architecture butterfly legs. Additionally, sandwich‐structured designed to mimic alternating rigid porous layered scales wings, featuring a foamed composite core sandwiched between solid skins, leading superior mechanical thermal management performance. Compared current industrial substitute for metallic structural components, tailorable achieve improvements up 32%, 36%, 116% specific tensile strength, flexural impact respectively, as well 66% insulation 62% performance, 38% weight reduction. These advancements stem from detailed structure‐property designs, spanning across multiple length‐scales, formulating fundamental understanding how tune meet stringent requirements. Ultimately, cost‐effective, industry‐ready produce lightweight, components showcase potential biomimicry advancing sustainable engineering solutions.

Language: Английский

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Nanogenerators developed based on different physics effects

MRS Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

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Piezoelectric enables Universality Enhancement of conventional water Treatment: Mechanisms, Effects, and challenges

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161704 - 161704

Published: March 1, 2025

Language: Английский

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High-performance piezoelectric flexible nanogenerators based on GO and polydopamine-modified ZnO/P(VDF–TrFE) for human motion energy capture, shared bicycle nanoenergy harvesting, and self-powered devices

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137666 - 137666

Published: April 1, 2025

Language: Английский

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Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 38852 - 38879

Published: July 23, 2024

Biophysical and clinical medical studies have confirmed that biological tissue lesions trauma are related to the damage of an intrinsic electret (i.e., endogenous electric field), such as wound healing, embryonic development, occurrence various diseases, immune regulation, regeneration, cancer metastasis. As exogenous electrical signals, conductivity, piezoelectricity, ferroelectricity, pyroelectricity, bioelectroactives can regulate field, thus controlling function cells promoting repair regeneration tissues. Materials, once polarized, harness their inherent polarized static fields generate field through direct stimulation or indirect interactions facilitated by physical friction, ultrasound, mechanical stimulation. The interaction with microenvironment allows for regulation compensation signals in damaged microenvironments, leading repair. technique shows great promise applications regeneration. In this paper, generation change electroactive substances expounded, latest research progress its effects include bone repair, nerve drug penetration promotion, etc. Finally, opportunities challenges materials were summarized. Exploring development new mechanism regulating changes may provide insights innovative methods disease treatment applications.

Language: Английский

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