Recent Progress of Conductive Hydrogel Fibers for Flexible Electronics: Fabrications, Applications, and Perspectives

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(17)

Published: Jan. 31, 2023

Abstract Flexible conductive materials with intrinsic structural characteristics are currently in the spotlight of both fundamental science and advanced technological applications due to their functional preponderances such as remarkable conductivity, excellent mechanical properties, tunable physical chemical so on. Typically, hydrogel fibers (CHFs) promising candidates owing unique including light weight, high length‐to‐diameter ratio, deformability, Herein, a comprehensive overview cutting‐edge advances CHFs involving architectural features, function characteristics, fabrication strategies, applications, perspectives flexible electronics provided. The design principles strategies systematically introduced discontinuous (the capillary polymerization draw spinning) continuous wet spinning, microfluidic 3D printing, electrospinning). In addition, potential crucially emphasized energy harvesting devices, storage smart sensors, biomedical electronics. This review concludes perspective on challenges opportunities attractive CHFs, allowing for better understanding fundamentals development materials.

Language: Английский

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Design aspects and characterization of hydrogel-based bioinks for extrusion-based bioprinting

Bioprinting, Journal Year: 2023, Volume and Issue: 32, P. e00274 - e00274

Published: April 15, 2023

3D-bioprinting has become a valid technique for tissue and organ regeneration, as the printing of living cells is allowed while hydrogel-based ink material provides them mechanical structural support. Self-healing shear-thinning hydrogel inks can be considered most promising materials extrusion-based bioprinting (EBB), because extruded due to decrease in viscosity under shear, self-healed after removing which ensures safe shape fidelity bioprinting. To achieve best final result, some technique, biological aspects need considered. In addition, versatile characterization pre- post-printing properties helps improve bioprinted constructs. However, despite great advances 3D-bioprinting, related challenges such opposing characteristics, lack controllable micro-environment, or technological increase speed print resolution must resolved. terms characterization, more standardization also needed. computational modeling would help performance construct. Thus, future going towards larger multifunctional tissue/organ constructs with multi-scale vascularization innervation. Multiple techniques are probably combined, but completely new Further, multimaterial enable heterogeneity gradients On other hand, using 4D-bioprinting, dynamic nature complex organs could added By combining microphysiological platforms (tissue- organ-on-a-chip systems) development functional tissues intended implantation go forward. The translation EBB into clinical practice still early stages, potential regenerative medicine challenges, biomimicry, reproducibility up-scaling issues have been overcome. this review, design property requirements ideal bioink, bioinks presented. Also, prospects discussed.

Language: Английский

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Self‐Healing Materials for 3D Printing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: March 21, 2024

Abstract Additive manufacturing/3D printing is praised as revolutionary by many because it enables the decentralized and on‐demand manufacturing of complex shapes. With ongoing rapid development increased availability these technologies, has become crucial to develop novel materials with unique functionalities for 3D‐printed components. Advances in self‐healing have resulted structures capable recovering from physical damage through material remendability. By applying solutions 3D printing, researchers are attempting overcome current barriers such low mechanical properties, waste, printability issues, among others. This review summarizes state research on used presents recent progress The particular focus use intrinsic polymer self‐healing, which prominent published literature. mechanisms proposed systems well their composition highlighted, intended application respect focused on. scientific technological challenges involved implementation approaches potential functional applications new also discussed.

Language: Английский

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Designing advanced hydrogel inks with direct ink writing based 3D printability for engineered biostructures

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112736 - 112736

Published: Jan. 4, 2024

Language: Английский

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Design Parameters for Injectable Biopolymeric Hydrogels with Dynamic Covalent Chemistry Crosslinks

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(27)

Published: June 30, 2023

Dynamic covalent chemistry (DCC) crosslinks can form hydrogels with tunable mechanical properties permissive to injectability and self-healing. However, not all transient are easily extrudable. For this reason, two additional design parameters must be considered when formulating DCC-crosslinked hydrogels: 1) degree of functionalization (DoF) 2) polymer molecular weight (MW). To investigate these parameters, comprised recombinant biopolymers: a hyaluronic acid (HA) modified benzaldehyde an elastin-like protein (ELP) hydrazine (ELP-HYD), formulated. Several hydrogel families synthesized distinct HA MW DoF while keeping the ELP-HYD component constant. The resulting have range stiffnesses, G' ≈ 10-1000 Pa, extrudability, which is attributed combined effects DCC entanglements. In general, lower formulations require forces for injectability, regardless stiffness. Higher exhibit more rapid Gel extrusion through cannula (2 m length, 0.25 mm diameter) demonstrates potential minimally invasive delivery future biomedical applications. summary, work highlights that influence network formation aims guide injectable hydrogels.

Language: Английский

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Granular Biphasic Colloidal Hydrogels for 3D Bioprinting

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Granular hydrogels composed of hydrogel microparticles are promising candidates for 3D bioprinting due to their ability protect encapsulated cells. However, achieve high print fidelity, need jam exhibit shear-thinning characteristics, which is crucial printing. Unfortunately, this overpacking can significantly impact cell viability, thereby negating the primary advantage using shield cells from shear forces. To overcome challenge, a novel solution: biphasic, granular colloidal bioink designed optimize viability and printing fidelity introduced. The biphasic ink consists cell-laden polyethylene glycol (PEG) embedded in continuous gelatin methacryloyl (GelMA)-nanosilicate network. Here, it demonstrated that offers outstanding rheological properties, structural stability. Furthermore, its utility engineering complex tissues with multiple types heterogeneous microenvironments demonstrated, by incorporating β-islet into PEG endothelial GelMA-nanosilicate Using approach, possible induce patterning, enhance vascularization, direct cellular function. proposed holds significant potential numerous emerging biomedical applications, including tissue disease modeling.

Language: Английский

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Adoption of a Tetrahedral DNA Nanostructure as a Multifunctional Biomaterial for Drug Delivery

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(8), P. 2204 - 2214

Published: July 24, 2024

DNA nanostructures have been widely researched in recent years as emerging biomedical materials for drug delivery, biosensing, and cancer therapy, addition to their hereditary function. Multiple precisely designed single-strand DNAs can be fabricated into complex, three-dimensional through a simple self-assembly process. Among all of the synthetic nanostructures, tetrahedral (TDNs) stand out most promising nanomaterial. TDNs possess merits structural stability, cell membrane permeability, natural biocompatibility due compact structures origin. In inherent advantages, were shown great potential delivering therapeutic agents multiple functional modifications. As multifunctional material, enabled innovative pharmaceutical applications, including antimicrobial anticancer treatment, immune modulation, cartilage regeneration. Given rapid development field, it is critical understand how successfully produce fine-tune properties specific needs clinical translation. This article provides insights synthesis functionalization summarizes approaches TDN-based therapeutics delivery well broad applications field pharmaceutics nanomedicine, challenges, future directions.

Language: Английский

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Hybrid polymeric scaffolds for potential applications in nerve and muscle regeneration

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 359 - 393

Published: Jan. 1, 2025

Language: Английский

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Thiol‐X Chemistry: A Skeleton Key Unlocking Advanced Polymers in Additive Manufacturing

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract Using additive manufacturing (AM) technologies for the fabrication of advanced polymeric objects is a logical progression to realize their potential within engineering applications that demand complex geometries. Thiol‐X chemistry has presented itself as diverse and invaluable toolkit accomplish such, satisfying both processing requirements properties desired fabricate range using variety AM technologies. The “click” nature many thiol‐X reactions, mechanisms polymerization, functional group tolerance orthogonality, desirable achievable with presents synergistic opportunity few other chemistries can broadly facilitate. As result, use gained rapid traction in recent years it now case are being viewed two sides same coin, whereby scope limitations whole system appreciated. This review highlights advancements, status, scope, opportunities achieve polymers by critically examining structure‐property‐processing‐performance relationships between different various

Language: Английский

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Challenges and Innovative Strategies in 3D Printing of Natural Biomolecular Hydrogels

Nano Select, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

ABSTRACT Natural biomolecules with excellent biocompatibility, degradability, and the ability to guide effective tissue regeneration are considered ideal materials for constructing engineering hydrogel scaffolds. The employing of 3D printing technology facilitates preparation natural biomolecular‐based scaffold specific morphological requirements engineering. However, there significant limitations in precise manufacturing such scaffolds using extrusion‐based technology. In this review, we put forward challenges encountered process biomolecular inks. Building upon this, summarize discuss strategies commonly employed enhance performance inks, including inducing rapid ink cross‐linking, improving rheological properties, incorporating auxiliary inks shaping, flexibly controlling extrusion, optimizing equipment. Furthermore, review offers a perspective on future design development technologies based

Language: Английский

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